Chapter 25 Flashcards
Metabolism and nutrition on homeostasis
harvest cheical energy from consumed nutrients to contribute to bodys growth, repair and normal functioning
what do most food molecules supply and what do the others serve as
most- energy
some- building blocks
other- stored for future use
what is metabolism
all the chemical reactions that occur in the body
Metabolism is a balance of what two main types of reaction
catabolic and anabolic
what is a catabolic reaction
break down complex molecules into simpler ones
exergonic
ex. glycolysis krebs cycle and electron transport chain
what is anabolic reaction
combine simple molecules and monomers to form bodys complex structural and functional components
- generally endergonic
e. formation of peptide bonds, building fatty acids, linkage of glucose monomers to form glycogen
what is the molecule that participates most often in energy exchanges in living cells
ATP
what does ATP do
couples energy releasing catabolic reactions to energy requiring anabolic reactions
what is the process of digestion of carbs in the GI tract
poly and disaccharides become monosaccharides (glucose fructose galactose)
hepatocytes: most fructose and galactose ->glucose
What is the fate of glucose (4 steps)
- ATP production - glucose is oxidized to produce ATp or glucose can enter another metabolic pathway
- Amino acid synthesis
- glycogen synthesis - hepatocytes and muscle fibers (glycogenesis)
- triglyceride synthesis - when glycogen stores are maxed out. hepatocytes: glucose->glycerol and fatty acids->synthesis of triglycerides
what is the synthesis of triglycerides
lipogenesis
what is the 2 steps of glucose entry into cells
- absorption from go tract: NA+ glucose symporters (secondary active transport)
- blood to cells: GluT(facilitated diffusion) - insulin increase # of GluT4
What is the oxidation of glucose to ATP
cellular respiration
what are the4 sets of reactions in glucose catabolism
glycolysis, formation of Acetyl coenzyme A,
krebs cycle, electron transport chain
what happens in glycolysis and is it anaerobic or aerobic
1 glucose -> 2 pyruvic acid + 2 ATP + 2 NADH + 2H (anaerobic)
what happens in formation of Acetyl Coenzyme A
2 pyruvic acid - > Acetyl CoA
+ 2 CO2 + 2 NADH + 2 H+
krebs cycle formula
2 Acetyl CoA -> 2ATP + 4CO2
+ 6NADH + 6H+ + 2 FADH2
electron transport chain formula
10NADH + 10H+ + 2 FADH2 + 6O2
-> 32 (or34) ATP + 6H20
What is Glycolysis
series of 10 reactions
Where does glycolysis occur
occurs in the cell cytosol
In glycolysis what happens
glucose ->2 pyretic acid
2 ATP used, 4 ATP produced
net gain 2 ATP
what is reaction #3 of glycolsis
Reaction #3
Fructose-6-phosphate -> Fructose 1,6bisphosphate
Catalyzed by enzyme : PHOSPHOFRUCTOKINASE
REGULATOR OF RATE OF GLYCOLYSIS
what determines the rate of glycolysis
slowest enzyme
If ADP is high during glycolysis what happens
high enzyme activity
high rate glycolysis
if low enzyme activity during glycolysis what happen
little glycolysis
most glucose ->glycogen
the fate of pyruvic acid depends on what
availability of O2
if aneaerobic (no O2) then what occurs with pyruvic acid and formation of acetyl CoA
2 pyruvic acid +2NADH +2H+ -> 2 lactic Acid +2NAD+
if aerobic (has O2) then what occurs with pyruvic acid and formation of acetyl CoA
2 pyruvic acid -> 2 Acetyl Coenzyme A
(in mitochondrial matrix)
2 Pyruvic acid -> 2 Acetyl Group
catalyzed by: PURUVATE DEHYDROGENASE
produces 2 CO2 and 2NADH + 2H+
2 Acetyl Group + 2 Coenzyme A ->
2 Acetyl Coenzyme A
Acetyl coenzyme A =
substrate for Krebs cycle
it drives the krebs cycle
where does the krebs cycle occur
matrix of mitochondria
what happens in the krebs cycle
- a series of redox and decarboxylations
- release CO2
- chemical energy is transferred to NAD+ & FAD
- odidation of pyruvic acid derivatives
- reduction of conexzymes (NAD &FAD)
- > NADH & FADH2
- > energy carries into electron transport chain
- 12 molecules of ATP generated
- release of CO2
2 acetyl CoA - > 6 NADH + 6H+ + 2 FADH2 + 4CO2 + 2ATP
krebs cycle
where does electron transport chain occur
inner mitochondrial membrane
what happens to the carriers in chain during ETC
- reduced as puck up electrons
2. oxidized as gives up electrons
exergonic reaction in ETC release energy to make
ATP
Brief summary of ETC
(1) Energy from NADH + H+ passed along the transport chain, used to pump H+ into Inter mitochondrial membrane space (proton pump) (2) ->High H+ concentration in space (3) H+ diffusion down H+ concentration gradient drives ATP synthase to make ATP
in glycolysis and krebs cycle what happens to coenzymes
pumped across intermitochondrial membraine and then come back in to make ATP
what produced in catabolism is
metabolic water
carbohydrate metabolism or catabolism formula
C6H12O6 + 6 O2 + 38 ADP + 38Pi –> 6 CO2 + 6 H2O + 38 ATP
(anabolism) glucose storage is called ____ because what
glycogenesis because glucose can be stored as glycogen
(anabolism) how does glycogenesis occur
insulins stimulates hepatocytes and skeletal muscle to perform glycogenesis
(anabolism) What is glucose release called
glycogenolysis
(anabolism) glycogen can be broke down into ____ for use by _____
glucose
hepatocytes
(anabolism) ___ and ____ activate enzyme phosphorylase (NB phosphates is absent in skeletal muscle)
glucagon and epinephrine
(anabolism) Glucose from proteins and fats is called
glucoeogenesis
(anabolism) when live is low on glycogen this means
time to eat
(anabolism) if you don’t eat what happens to your body
it starts catabolizing triglycerides and proteins