Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > Chapter 24: Antiseizure Drugs > Flashcards

Chapter 24: Antiseizure Drugs Flashcards

1
Q

Antiseizure drugs with sodium channel blockade:

A
  1. Phenytoin
  2. Carbamazepine
  3. Lacosamide
  4. Lamotrigine
  5. Zonisamide
  6. Topiramate (in part)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Antiseizure drugs with GABA-related targets:

A
  1. Benzodiazepines
  2. Barbiturates (Phenobarbital)
  3. Vigabatrin
  4. Tiagabine
  5. Valproate
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Antiseizure drugs with calcium channel blockade:

A
  1. Ethosuximide
  2. Valproate
  3. Gabapentin
  4. Pregabalin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Antiepileptics teratogenicity:

Valproic acid

A

Neural tube defects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Antiepileptics teratogenicity:

Carbamazepine

A
  1. Craniofacial anomalies

2. Spina bifida

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Antiepileptics teratogenicity:

Phenytoin

A

Fetal hydantoin syndrome

  • wide set eyes
  • upturned nose
  • mild midfacial hypoplasia / broad mandible
  • long upper lip with thin vermilion border
  • lower distal digital hypoplasia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Antiseizure drug which induces formation of liver drug-metabolizing enzymes that increase metabolism of the drug itself and may increase the clearance of many other anticonvulsant drugs

A

Carbamazepine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

In addition to competing for phenytoin plasma protein binding sites, this drug inhibits the metabolism of carbamazepine, ethosuximide, phenytoin, phenobarbital, and lamotrigine.

This is hepatotoxic.

A

Valproic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Increases the FREQUENCY of GABA-mediated Cl- channel opening

A

Benzodiazepines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Increases the DURATION of GABA-mediated Cl- channel opening

A

Barbiturates

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Antiseizure drug that binds the SV2A protein on glutamate-containing transmitter vesicles and reduces glutamate release.

A

Levetiracetam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Drugs of choice for generalized tonic-clonic (grand mal) seizures

A
  1. Valproic acid
  2. Carbamazepine
  3. Phenytoin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

The drugs of first choice for focal (partial) seizures

A
  1. Carbamazepine (or oxcarbazepine)
  2. Lamotrigine
  3. Phenytoin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

The drugs of first choice for absence seizures because they cause minimal sedation

A
  1. Ethosuximide

2. Valproic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Myoclonic seizure syndromes are usually treated with:

A

Valproic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Intravenous antiepileptics usually effective in termi- nating attacks and providing short-term control of myoclonal and atypical absence seizures

A
  1. Diazepam

2. Lorazepam

17
Q

Now often used as a first-line drug in the treatment of mania

A

Valproic acid

18
Q

What is the drug of choice for trigeminal neuralgia?

A

Carbamazepine

Pharmacology (27 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions