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Systems Path 2 Test 1 > Chapter 23 - Skin > Flashcards

Chapter 23 - Skin Flashcards

1
Q

Acute inflammatory dermatoses

A

urticaria, acute ecxematous dermatitis, erythema multiforme

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2
Q

chronic inflammatory dermatoses

A

psoriasis, lichen planus, lichen simplex chronicus

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3
Q

macule

A

flat discoloration

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4
Q

papule

A

elevated done

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5
Q

plaque

A

flat-topped elevation

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6
Q

scale

A

dry, horny, platelike growth

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7
Q

vesicle, bulla

A

fluid filled area…. >5 mm is bulla

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8
Q

wheal

A

raised area of edema, AKA hive

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9
Q

acantholysis
acanthosis
Hyperkeratosis

A

loss of keratinocyte adhesion
epidermal hyperplasia
hyper stratum corneum

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10
Q 
type I hypersensitivity---mast cell degranulation
multiple wheal (isolated or diffuse)
A

Urticaria—Hives

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11
Q

IgE dependent urticaria is assoc with

IgE independent with

A

common allergens

medications (opiates, antibiotics)

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12
Q

ex cessive complement activation
trauma, menstratuion, stresss, —-
various meds, viral infxn

A

hereditary angioedema

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13
Q

various stimuli, multipla appearancess
Acute: red, nblisters, oozing, crusts
Chronic: raised scaling plaque

A

Acute eczematous dermatitis

eczema

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14
Q

eczema is a mix of hypersensitivities

A

Type I and type IV

itchy—-scratching may cause trauma

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15
Q

MC type of ezcema

A

allergic contact dermatitis
CD 4+ T cell sensitization
limited to contact site

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16
Q

inherited risk of hypersensitivity
—atopic triad : dermatitis, asthma, rhinitis
Onsets in childhood, improves with age

A

Atopic dermatits (atopic eczema)

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17
Q

Type 4 hypsersensitivity–rare, selt-limited
infectious
drug reaction

A

Erythema Multiforme

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18
Q

how does erythema multiforme present itself

A

red macule, pale eroded center

targetoid lesion

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19
Q

post infxn, milder

A

erythema multiforme minor

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20
Q

drug related, aggressive

sloughing of epidermis, fluid loss, infection

A

erythema multiforme Major

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21
Q

autoimmune–unknow antigens, t cells in epidermis
lifelong
2% of population—

A

psoriasis

epidermal hyperplasia, itchy

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22
Q

MC in extremities—Wickham’s striae in oral cavity

A

lichen planus

23
Q

idiopathis
repetitive trauama
epidermal hyperplasia & dermal scarring–raised itchy scale

A

lichen implex chronicus

24
Q

S. aureus 80%… strep pyogenes
contagious
“honey-colored” crust or abscess ( when deeper)

A

Impetigo
Children!—mouth, nose
Neutrophils battle

25
Q

what is pus?

A

dead WBC, edema, idk

26
Q

how is impetigo transferred?

A

direct contact—-think wrestling

27
Q

Deeper infxn, puncture wounds or burn site

A

Pseudomonas aeruginosa

28
Q

what percent of blood do you need to lose in order for shock?

A

20%

29
Q

Intense itchiness, Superficial or deep layers of skin or nail bed—-almost could be psoriasis

A

mycosis, dermatophytosis, tinea “ringworm”

30
Q

Fungal, immunodeficiency
Angioinvasive: lungs-to-blood
aspergilloma

A

Aspergillus fumigatus

31
Q

what is tinea corporis

A

non hairy skin area where you will get fungal infxn

32
Q

what is tinea barbae?

A

beard (hair follicle)

33
Q

pediatrics, warts

most are self-limited

A

HPV infxns 6 and 11\

HPV-16 and HPV-18

34
Q

HPV carries e6 and e7

A

e6 makes p53 into tp53

e7 makes Rb into RB

35
Q

blistering disorders (bullous)

A

pemphigus
bullous pemphigoidj
dermatitis herpetiformi

36
Q

Autoimmune, rare
Middle aged/ elderly women
Type 2 hypersensitivity IgG anitbodies
Fish-net like pattern

A

pemphigus

37
Q

most commnon type of pemphigus
Skin & mucosa—face, scalp, axillae, groin
Blisters are suprabasal

A

Pemphigus vulgaris

38
Q

skin only—no mucosa

blisters are corneal

A

pemphigus foliaceus

39
Q

what is acantholysis?

A

separation of cells

40
Q

skin and mucosa of tho forearm, axilla, groin
Blisters are subepidermal
Autoimmune, older adults

A

Bullous pemphigoid
“tense bullae”
outer epidermis is fully intact

41
Q

location—torso, gluteal, elbows, knees
autoimmune—10% of celiac patients
males, 20-40

A

dermatitis herpetiformis

42
Q

dark, flat, round, “coin-like”, “stuck on”—Leser-Trelat sign
More

A

seborrheic keratosis

43
Q

benign skin lesions in oily areas of body–head/neck
slow growing
nearly flesh tone

A

sebaceous adenoma

44
Q

dysplastic (pre-cancer)—-atypia
sun-exposed areas
small, tan/broqn, “sandpaper like” lesions
tx. local eradication

A

actinic keratosis

45
Q

2nd MC skin cancer

older adultsm sun-exposed skin

A

Squamous cell carcinoma

46
Q

Risks, Total UV, males, burnsm ionizing rad, tar/oil, arsenic, chronic ulcers

A

squamous cell carcinoma

47
Q 
MC skin cancer
older adults, sun-exposed
Risks UV, mutated tumor suppressor genes
PTCH (hedgehog path) 
TP53
A

Basal Cell carcinoma

48
Q

What is the atopic triad?

think back to atopic dermatitis

A

atopic dermatitis, asthma, and allergic rhinitis

49
Q

what can appear alongside erythema multiforme?

A

antecedent infxns include HSV and those caused by mycoplasmas and some fungi

50
Q

you will see this skin condition in 10% of patients with arthritis

A

psoriasis

51
Q

Psoriasis induced by local trauma in susceptible persons is termed whaat

A

Koebner phenomenon—a local inflamm response that promotes lesion development

52
Q

what is auspitz sign

A

multiple bleeding points assoc with psoriasis

53
Q

what is wickham striae

A

white dots or lines hightlighting the papules of lichen planus

Systems Path 2 Test 1 (3 decks)

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