Chapter 21,22,23 Exam review Flashcards
What is lymph and where does it come from?
Lymph is fluid which is water, protein, and dissolved solutes, moved within the lymph capillaries and comes from our tissue
Where do the lymphatic capillaries begin?
immediately below the skin
What is the force that drives fluid inside capillaries?
Hydro-static pressure of interstitial fluid. Pressure of lymph inside vessel force inter-cellular openings of capillary wall to close with lymph inside
What are the 2 main functions of the lymphatic system?
Immunity, and fluid balance
List lymphatic vessels in order according to size?
Lymph capillaries feed lymph vessels, lymph vessels feed lymphatic trunks, and lymphatic trunks feed lymphatic ducts.
Lymph from the right leg would drain into where?
the lumbar trunks
Where do the lymphatic ducts drain?
The thoracic duct drains into the left subclavian vein, while the right lymphatic duct drains into the right subclavian vein.
Where do the T and B cells mature?
T lymphocytes migrate to thymus to complete maturation. B lymphocytes in red bone marrow
What are B lymphocytes
Blood formed elements, involved with humoral immunity
What happens to the thymus as we age?
Gets smaller
What is MALT?
(mucosal-associated lymphatic tissue) is a secondary lymphatic structure, does not form lymphocytes, but house and other immune cells immune response initiation. MALT is located in the GI, respiratory, genital and urinary tract also found in lamina proria of mucosa. Helps defend against foreign substances. Prominent small intestine, especially in the ilium.
When women with breast cancer undergo surgery to remove the tumor or entire breast, the axilary lymph nodes are often removed as well. Why?
The axillary lymph nodes receive lymph from the breast and may contain cancer cells.
What do the tonsils do?
Detect and protect against infectious agents that are ingested or inhaled
What is NOT correct regarding lymph nodes?
They are drained by different afferent lymphatic vessels.
What is red pulp?
Part of spleen that functions as blood reservoir, hemolysis which is phagocytosis of old erythrocytes and platelets; removes debris from blood
What is white pulp?
Part of spleen that contains lymphocytes and macrophages; monitors blood for foreign atigens and initiated an immune response
What are the functions of the spleen?
Filter’s and monitors blood
A Virus is
smaller than a cell and composed of DNA or RNA in a protein shell
Where do we get dendritic cells of the skin?
destroy particles and then present fragments
Antigens are presented on dendritic cell surface to T-lymphocytes
initiate adaptive immunity
Macrophages can also perform antigen presentation
What are the functions of cytokines?
small proteins that regulate immune activity. Produced by cells of both innate and adaptive immune system. Chemical messengers released from one cell that bind to receptor of target cells
Epithelial layers of skin and mucosal membranes house dendritic cells
These dendritic cells are usually derived from monocytes
Engulf pathogens and migrate into lymph
What is the 1st, 2nd, and 3rd line of defense in order?
Innate immunity (present at birth) protects against a variety of substances
2nd
Adaptive immunity (aquired immunity). Response to antigen involves specific T and B-lymphocytes-plasma cells synthesize and release antibodies. Takes several days to be effective.
Steps in innate immunity
Skin and mucosal membrane (prevent entry, nonspecific internal defenses, cells , macrophages, NK cells. Chemicals interferon, complements, Physiologic responses, inflammation, fever.
Neutrophils and magrophages
destroy and engulf particles
Eosinophil
Only attacks parasites ex. protozoans/multicellular parasites. Have a role in allergy response
NK cells destroy a variety of unwanted cells. They kill by releasing chemical toxins called
Granzymes enter pore, cause apoptosis of cell
Apoptosis is cell death that causes shriveling rather than lysis
Compliment system
group of over 30 plasma proteins. Work along with compliment antibodies. Synthesized by liver, continuously released in inactive form
Complement system
When a foreign substance enters body, this system becomes active, usually used for bacteria. Opsonization, inflammation, cytolysis, rbc/antibody connection