Chapter 2 - Research Environment

Question 1

What is the primary source of standards and guidelines for lab animal care and use in the US?

Answer 1

Guide for the Care and Use of Laboratory Animals

Question 2

What is the federal mandate that covers all live vertebrates used in research?

Answer 2

PHS Policy

Question 3

What are written instructions approved by management and used to perform a routine activity called?

Answer 3

Standard Operating Procedures (SOP)

Question 4

What IACUC approved document written by the Principal Investigator describes and justifies the use of animals for a project?

Answer 4

Animal use protocol

Question 5

What regulations were developed by the Food & Drug Administration and the Environmental Protection Agency to validate and document the processes of safety testing?

Answer 5

Good Laboratory Practices

Question 6

What two government agencies developed the Good Laboratory Practices?

Answer 6

FDA

EPA

Question 7

What three types of members must make up IACUC?

Answer 7

The Chair (A scientist in Lab Animal Research)
A veterinarian
A non-affiliated member (no connection to animal research industry)

Question 8

What are some components of an animal care and use program for which the Guide describes standards?

Answer 8

Personnel qualifications and training
Occupational health and safety
Veterinary care
Animal environment
Animal procurement and transportation
Surgical and post surgical care
Alleviation of pain and distress
Euthanasia
Plant design and construction

Question 9

What are the 3 Rs?

Answer 9

Replacement
Refinement
Reduction

Question 10

What document must institutions comply with when euthanizing?

Answer 10

AVMA Guidelines for Euthanasia

Question 11

Common alternatives to using animals?

Answer 11

Cellular cultures

Mathematical models