Chapter 2 - Chemical Messengers Flashcards

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1
Q

exocrine glands

A

πŸ’š secrete into duct

πŸ’š duct carries secretion to body surface/body cavities

πŸ’šsweat glands
πŸ’šmucous glands
πŸ’šsalivary glands
πŸ’šglands of alimentary canal

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2
Q

endocrine glands

A

πŸ’š secrete hormones

πŸ’š secrete them into extracellular fluid of cell that makes up gland

      ⚫ secretion then passes into capillaries/bloodstream
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3
Q

The Endocrine Glands

A
πŸ’š hypothalamus 
πŸ’š pituitary
πŸ’š pineal
πŸ’š thyroid 
πŸ’š parathyroid 
πŸ’š thymus  
πŸ’š adrenal glands 
πŸ’š pancreas
πŸ’š gonads
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4
Q

Hormones

A

πŸ’š secretion of an endocrine gland

πŸ’š proteins and amines
πŸ’š steroid

πŸ’š transported in blood

πŸ’š can affect all cells of body or specific cells (target cells)/organs (target organs)

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5
Q

paracrines

A

πŸ’š local hormones

πŸ’š diffuse from cells to adjacent cells

πŸ’š move through extracellular fluid (not bloodstream)

πŸ’š for cells to communicate with other cells

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6
Q

protein and amine hormones

A

πŸ’š attach to receptor proteins in MEMBRANE of target cell

πŸ’š receptor proteins
β˜‘οΈ are specific
β˜‘οΈ only a certain amount
β˜‘οΈ different cells have different types and amounts

πŸ’š hormone βž• receptor ➑️ secondary messenger substance

secondary messenger substance
                β˜‘οΈ diffuses through cell 
                β˜‘οΈ activates particular enzymes
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7
Q

steroid hormones

A

πŸ’š combine with receptor protein INSIDE CELL
(mitochondria, nucleus, other organelles)

hormone-receptor complex 
                    β˜‘οΈ activates genes 
                    β˜‘οΈ the genes control forming of particular protein
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8
Q

Hormones can…

A

1️⃣ activate certain genes in nucleus

2️⃣ change shape of enzyme (so it’s turned ON or OFF)

3️⃣ change rate of production of an enzyme

      β˜‘ done by changing rate of transcription/translation
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9
Q

enzyme amplification

A

πŸ’š production of thousands of enzymes via bondage of hormone to receptor

hormone triggers cascading effect

➑️ no. of molecules involved increases x1000s for each step along metabolic pathway

πŸ’š small stimulus = very large effect

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10
Q

hormone clearance

A

1️⃣ hormone molecules broken down

    β˜‘οΈ in liver/kidneys 
    β˜‘οΈ some in target cells 

2️⃣ degraded hormones secreted

    β˜‘οΈ bile 
    β˜‘οΈ urine
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11
Q

Negative feedback system

A

πŸ’š control of hormone secretions

β˜‘οΈ regulates hormone secretions
β˜‘οΈ response produced
➑️ opposite of stimulus that caused the secretion

β˜‘οΈ regulating factors from hypothalamus
➑️ regulate function of pituitary

β˜‘οΈ releasing factors from hypothalamus
➑️ stimulate release of a hormone OR inhibiting factors

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12
Q

Hypothalamus

A

πŸ’š regulating and maintaining internal environment

    β˜‘οΈ body temperature 
    β˜‘οΈ water balance 
    β˜‘οΈ heart rate 

πŸ’š located at the base of the brain

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13
Q

Pituitary gland

A

πŸ’š absolutely vital to internal functioning of body

πŸ’š anterior and posterior lobe

πŸ’š underneath and connected to hypothalamus
➑️ infundibulum

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14
Q

Anterior lobe of pituitary

A

πŸ’š releases hormones that regulate bodily activities

πŸ’š secretions controlled by releasing/inhibiting factors from hypothalamus
(extracellular fluid -> bloodstream)

πŸ’š connected to hypothalamus by complex network of blood vessels

πŸ’š FLATPEG

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15
Q

Hormones released by anterior lobe

A
πŸ’š FHS
πŸ’š LH
πŸ’š ACTH (adrenocorticotropic hormone)
πŸ’š TSH 
πŸ’š Prolactin 
πŸ’š Endorphins*
πŸ’š Growth hormone (GH)
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16
Q

Posterior lobe

A

πŸ’š not a true gland

   ➑️ release hormones produced by hypothalamus 

πŸ’š connected by special neurosecretory cells (neurons)

   ➑️ hormones produced in these cells 
   ➑️ stored ready for release in posterior 
          β†ͺ️ then released into bloodstream
17
Q

Hormones produced in posterior

A

πŸ’š oxytocin

πŸ’š anti-diuretic hormone

18
Q

Pineal gland

A

πŸ’š secretes melatonin
➑️ regulation of sleep patterns
➑️ stimulated by darkness and inhibited by light

πŸ’š located deep inside brain, tiny

19
Q

Thyroid gland

A

πŸ’š in the neck

πŸ’š two lobes on either side of trachea

πŸ’š secretes thyroxine
➑️ controls body metabolism

20
Q

Parathyroid glands

A

πŸ’š four

πŸ’š embedded in rear surface of lobes of thyroid

πŸ’š secrete parathyroid hormone (PTH)

         ➑️ controls calcium and phosphate levels in blood
21
Q

Thymus

A

πŸ’š located in chest just above the heart, behind sternum

πŸ’š secretes hormones called thymosins

                         ➑️ maturation of T-lymphocytes 

πŸ’š shrinks after puberty

22
Q

Adrenal glands

A

πŸ’š one above each kidney

πŸ’š each adrenal gland has an
β˜‘οΈ adrenal cortex (outer)
β˜‘οΈ adrenal medulla (inner)

23
Q

Adrenal cortex

A

πŸ’š produce corticosteroids
(20 different hormones, 2 main ones)

1️⃣ aldosterone 
       (kidneys - decr sodium/incr potassium in urine)

2️⃣ cortisol 
       (helps promote normal metabolism, withstand stress, repair)
24
Q

Adrenal medulla

A

πŸ’š adrenaline - sympathetic division, fight or flight

πŸ’š noradrenaline - similar to adrenaline

                             β˜‘οΈ increases rate and force of heartbeat
25
Q

Pancreas

A

πŸ’š just below stomach, alongside duodenum

πŸ’š both and endocrine and exocrine gland

πŸ’š exocrine
β˜‘οΈ digestive enzymes

πŸ’š endocrine
β˜‘οΈ cells (islets of Langerhans/ pancreatic islets) secrete:

        1️⃣ insulin - reduces glucose in blood 
        2️⃣ glucagon - increases glucose in blood
26
Q

Gonads

A

πŸ’š androgens
β˜‘οΈ male sex hormones
β˜‘οΈ testes

πŸ’š oestrogen and progesterone
β˜‘οΈ female sex hormones
β˜‘οΈ ovaries

27
Q

Other endocrine tissues

A

πŸ’š stomach and small intestine

β˜‘οΈ secrete hormones coordinating exocrine glands of digestive system

πŸ’š kidneys

β˜‘οΈ ethryropoietin (EPO)

 ➑️ stimulates production of RBCs by bone marrow 

πŸ’š heart

β˜‘οΈ hormone that helps reduce blood pressure

πŸ’š placenta

β˜‘οΈ hormones maintaining pregnancy (development of foetus, stimulate mothers mammary glands)

28
Q

Thyroxine

A

πŸ’š increases metabolic rate

πŸ’š target cells: most cells

πŸ’š thyroid gland

29
Q

Parathyroid hormone

A

πŸ’š increases calcium levels in blood

πŸ’š target cells: bones, kidneys

πŸ’š parathyroid glands

30
Q

Thymosins

A

πŸ’š stimulates development and maturation of T-lymphocytes (immune)

πŸ’š target cells: T-lymphocytes

πŸ’š thymus gland

31
Q

Aldosterone

A

πŸ’š increases reabsorption of sodium ions,
increases excretion of potassium ions

πŸ’š one of corticosteroids

πŸ’š target cells: kidney

πŸ’š adrenal cortex

32
Q

Cortisol

A

πŸ’š promotes normal metabolism
πŸ’š helps body with stress
πŸ’š promotes repair of damaged tissues

πŸ’š target cells: most cells

πŸ’š one of corticosteroids

πŸ’š adrenal cortex

33
Q

Adrenaline and noradrenaline

A

πŸ’š prepares body for fight-or-flight responses
πŸ’š reinforces effects effects of sympathetic nervous systems

πŸ’š target cells: most tissues

πŸ’š adrenal medulla

34
Q

Insulin

A

πŸ’š stimulates uptake of glucose (lowers BSL)

πŸ’š target cells: most cells

πŸ’š pancreas

35
Q

Glucagon

A

πŸ’š stimulates breakdown of glycogen and fat (increases BSL)

πŸ’š target cells: liver and fat storage tissues

πŸ’š pancreas

36
Q

Androgens

A

πŸ’š stimulate sperm production
πŸ’š growth of skeleton and muscles
πŸ’š male sexual characteristics

πŸ’š target cells: many tissues

πŸ’š testes

37
Q

Oestrogens

A

πŸ’š stimulate development of female characteristics
πŸ’š regulate menstrual cycle

πŸ’š target cells: many tissues

πŸ’š ovaries

38
Q

Progesterone

A

πŸ’š regulates menstrual cycle
πŸ’š regulates pregnancy
πŸ’š prepares mammary glands for milk secretion

πŸ’š target cells: uterus and mammary glands

πŸ’š ovaries

39
Q

Hormones of the anterior lobe

A

πŸ’š FSH

β˜‘οΈ ovaries: growth of follicles
β˜‘οΈ testes: production of sperm

πŸ’š Luteinising hormone

    β˜‘οΈ ovaries: ovulation, maintenance of corpus luteum
    β˜‘οΈ testes: secretion of testosterone 

πŸ’š Growth hormone

    β˜‘οΈ all cells
    β˜‘οΈ growth and protein synthesis 

πŸ’šTSH (thyroid