Chapter 2 Adverse drug event Flashcards
1
Q
Vomiting and diarrhoea may cause significant loss of which electrolyte from the gastrointestinal tract?
A
Potassium (K+)
2
Q
Define therapeutic index?
A
The margin between effectiveness and toxicity of drugs.
3
Q
The organ responsible for the excretion of most drugs and their metabolites is the?
A
Kidneys
4
Q
Dehydration results in?
A
Decreased glomerular filtration rate
5
Q
What is the action of the diuretic Frusemide?
A
It blocks the absorption of sodium, chloride and water from the filtered fluid in the kidney tubules, causing an increase in urine output.
6
Q
Frusemide may cause serum potassium levels to?
A
Decrease
7
Q
Enalapril should be used with caution in patients with ?
A
hypovolaemia or dehydration
