Chapter 2

Question 1

The Animal Welfare Act is administered by what agency?

Answer 1

USDA Animal and Plant Health Inspection Service

Question 2

What is the common test for the policy that most institutions have to protect an individual reporting instances of animal abuse or neglect?

Answer 2

Whistleblower policy

Question 3

Name the person to whom the IACUC is responsible.

Answer 3

Institutional Official

Question 4

What regulations were developed by the Food and Drug Administration (FDA) and the Environmental Protections Agency (EPA) to validate and document the process of safety testing?

Answer 4

Good Laboratory Practices (GLP’s)

Question 5

What agency is responsible for enforcing the Public Health Service Policy on Humane Care and Use of Laboratory Animals (PHS Policy) ?

Answer 5

Office of Laboratory Animal Welfare (OLAW)

Question 6

What document must be submitted to the USDA every year by an animal facility with USDA-covered species?

Answer 6

An annual report

Question 7

The PHS Policy on Humane Care and Use of Laboratory Animals applies specifically to what type of research?

Answer 7

Federally funded research

Question 8

If research is funded by agencies of the PHS, what document must the Institutional Official send to OLAW about the institution’s animal care and use program?

Answer 8

Animal Welfare Assurance of Compliance Statement or PHS Assurance

Question 9

T/F: Mice bred for research are not covered by the Animal Welfare Act.

Answer 9

True

Question 10

Upon request, USDA records are available to the public under what federal act?

Answer 10

Freedom of Information Act

Question 11

What IACUC approved document must a PI submit describing/justifying the use of animals for each research project involving lab animals?

Answer 11

Animal use protocol or Animal protocol

Question 12

T/F: The Animal Welfare Regulations is another name for the Animal Welfare Act.

Answer 12

False. The Animal Welfare Regulations describe what rules a facility must follow to comply with the AWA.

Question 13

What committee oversees the institution’s animal research programs?

Answer 13

IACUC (Institutional Animal Care and Use Committee)

Question 14

Name the 3 R’s Principles of Russell & Burch.

Answer 14

Refinement, Reduction, Replacement

Question 15

What is the federal mandate that covers all live vertebrates used in research?

Answer 15

PHS Policy

Question 16

What are written instructions approved by management and used to perform a routine activity called?

Answer 16

SOP’s (Standard Operating Procedures)

Question 17

What two government agencies developed Good Laboratory Practices?

Answer 17

EPA and FDA

Question 18

What three types of members must make up IACUC?

Answer 18

The Chair (A scientist in Lab Animal Research) 
A veterinarian
A non-affiliated member (no connection to animal research industry)

Question 19

What are some components of an animal care and use program for which the Guide describes standards?

Answer 19

Personnel qualifications and training 
Occupational health and safety
Veterinary care
Animal environment
Animal procurement and transportation 
Surgical and post-surgical care
Alleviation of pain and distress
Euthanasia 
Plant design and construction

Question 20

What document must institutions comply with when euthanizing?

Answer 20

AVMA Guidelines for Euthanasia

Question 21

Common alternatives to using animals?

Answer 21

Cellular cultures

Mathematical models