Chapter 18 Variation And Selection Flashcards
Define variation
The differences between individuals of the same species
Distinguish between Genetic Variation and Phenotypic Variation
Genetic Variation are variations determined by genes Phenotypic variations (observable characteristics) may be brought about by genes, but can also be caused by the environment, or a combination of both genes and the environment
Explain Continuous Variation
It results in a range of phenotypes between two extremes
Extra: controlled by a lot of genes and the environment Tends to be quantitative No limit No distinct categories
Represented by line graph
E.g. height, weight, heart rate
Explain Discontinuous Variation
It results in a limited number of phenotypes with no intermediates
Extra: it is under the control of a single pair of alleles or a small number of genes No in between categories Distinct categories Tends to be qualitative (non numerical)
Represented as a bar chart
Eg. Blood type, gender, tongue rolling
NIS: Genetic variation can be caused by
Mutation
Random mating
Random fertilization
Recombination between homologous chromosomes during meiosis
Define mutation
Mutation is spontaneous genetic change. It is the way new alleles are formed.
What are the causes of mutation?
Ionizing radiation and some chemicals increase the rate of mutation
- chemical mutagens (e.g tar from cigarette smoke )
- ionizing radiation (e.g gamma rays, X rays and ultraviolet rays)
the greater the dose of radiation a cell gets, the greater the chance of mutation
Define gene mutation
A change in the base sequence of DNA
Symptoms of sickle-cell anaemia
Weakness, aching joints and poor circulation
Describe what happens when one has sickle cell anaemia
RBC contain globular proteins called hemoglobin which are made of two alpha and two beta protein subunits.
Sickle cell anaemia is a blood disorder caused by a single base substation in the gene that codes for the beta subunit of hemoglobin.
When the mutation is transcribed by the mRNA, the resulting codon also contains the substitution and when the mRNA is translated, the mutant polypeptide has valine instead of glutamic acid as the sixth amino acid in the polypeptide chain.
Valine and glutamic acid have different chemical properties, so the polypeptide folds differently, the hemoglobin molecule differs in configuration and the RBC develops into sickle shape.
Sickle shaped RBC deliver oxygen inefficiently and their irregular shapes often block blood vessels. A person with the disease may develop severe symptoms of anaemia. The disease is deadly if left untreated
Using genetic diagrams, show how sickle cell anemia is inherited
Refer to slides
Who are resistant to malaria
People who are heterozygous (Hb^S Hb^A) for the sickle cell allele have a resistance to malaria
Distribution of sickle cell
The selection pressure of malaria favour the Heterozygotes over the homozygotes and the potentially harmful Hb^S allele is kept in the population
Hence, sickle cell disease is more prevalent in places with malaria.
When Africans migrate to countries where malaria does not occur, the selective advantage of the Hb^S allele is lost and the frequency of this allele in the population diminishes.
Define Adaptive features
Inherited functional features of an organism that increase its fitness and help it to survive and reproduce in its environment.
Define Fitness
The probability of an organism surviving and reproducing in the environment in which it is found