Chapter 17 Flashcards
How does blood exit the heart?
arteries
Arteries branch into what?
capillaries
_____ and _____ move from the tissues to the capillaries
CO2 and waste
What carries blood in need of oxygen back to the heart?
veins
What do capillaries contain?
O2 and nutrients such as:
- carbs
- amino acids
- fats
What are the 3 functions of blood?
transport, protect, and regulate
RBCs and plasma deliver _____ and _____ to body cells
O2 and nutrients
What wastes does blood transport to the kidneys and lungs for elimination?
CO2, drugs, small solutes
What transports hormones from endocrine organs to target organs?
plasma
_____ and _____ in blood initiate clot formation
plasma proteins (clotting factors and platelets
What 3 agents of immunity are carried in the blood?
- white blood cells
- complement proteins
- antibodies
What is specific heat capacity?
the amount of heat required to raise the temperature of 1g of substance by 1 degree Celsius
How does blood maintain normal pH levels?
buffers:
- bicarbonate
Blood is made of _____ and _____ ______
plasma and formed elements
What are the formed elements made of?
- erythrocytes
- leukocytes
- thrombocytes
What are red blood cells called?
erythrocytes
What are white blood cells called?
leukocytes
What are platelets called?
thrombocytes
What are the 3 layers of blood?
- RBCs
- buffy coat
- plasma
What percentage of blood is made up of erythrocytes?
45%
What is hematocrit?
the percentage of blood volume made up of erythrocytes
What is a normal male hematocrit?
47% +/- 5%
What is a normal female hematocrit
42% +/- 5%
What makes up the buffy coat?
WBCs and platelets
What percentage of blood is made up by the buffy coat?
<1%
What percentage of blood is made up by plasma?
55%
What color would high oxygenated blood appear as?
scarlet (bright) red
What color would low oxygenated blood appear as?
dark red
What is the pH range for blood?
7.35 - 7.45 (7.4 +/- 0.5)
What percentage of body weight is made up by blood?
8%
What is the average blood volume for males?
5-6L
What is the average blood volume for females?
4-5L
Plasma is 90% _____
water
What is the most abundant solute found in plasma?
plasma proteins
What plasma protein makes up 60% of plasma proteins?
albumin
What are 3 functions of albumin?
- carrier of hormones and drugs
- blood buffer
- contributes to plasma osmotic pressure
Do RBCs contain nuclei or organelles?
NO
What are platelets made of?
megakaryocytes
Most blood cells originate in _____ _____
bone marrow
Do blood cells divide?
NO
What cells divide in red bone marrow to replace blood cells?
stem cells
Why are RBCs good for gas transport?
they have a small diameter
What plasma protein provides flexibility for RBCs?
spectrin
What makes up 97% of RBC volume?
hemoglobin
What is a benefit from having no mitochondria (RBCs)?
they don’t consume the O2 they transport
Hemoglobin binds _____ with oxygen
reversibly
What is a normal Hb value for males?
13 - 18g/100mL
What is a normal Hb value for females?
12 - 16g/100mL
What does the red pigment heme bind to?
the protein globin
How man peptide chains does globin have?
4
Each heme _____ _____ binds to one O2
iron atom
What hemoglobin is produced when loading O2 in the lungs?
oxyhemoglobin (ruby red)
What hemoglobin is produced when unloading O2 in the tissues?
deoxyhemoglobin (dark red)
What hemoglobin is produced when loading CO2 into the tissues?
carbaminohemoglobin
What is hematopoiesis
formation of all blood cells
Hematopoiesis occurs in _____ bone marrow
red
Where is red bone marrow found in adults?
- axial skeleton
- girdles
- humerus
- femur
What are hematopoietic stem cells called?
hemocytoblasts
New blood cells enter:
blood sinusoids
Bone marrow transplants occur in:
sternum and hips
What is erythropoiesis?
formation of RBCs
What are the 6 steps of erythropoiesis?
- hematopoietic stem cell
- myeloid stem cell
- proerythroblast
- basophilic erythroblasts (blue), polychromatic erythroblasts (red), orthochromatic erythroblasts (pink)
- reticulocytes
- mature erythrocyte
What is hypoxia?
too few RBCs
What is the reason for increased blood viscocity?
too many RBCs
What is erythropoietin (EPO)?
hormone that stimulates formation of RBCs; released in response to hypoxia
Because there are too few RBCs due to hypoxia, there is less O2 in the cells. Without oxygen, kidneys can not degrade _____
hypoxia-inducible factor (HIF)
HIF triggers synthesis of _____
EPO
What are some causes of hypoxia?
- hemorrhage
- iron deficiency
- high altitudes or lung issues (pneumonia)
What hormone enhances EPO production causing higher RBC counts in males?
testosterone
What percentage of iron in the body is found in hemoglobin?
65%
Free iron ions are bound with proteins such as _____ and _____
keratin and hemociderin
What protein bound to iron is transported in the blood?
transferrin
What is the life span of RBCs?
100-120 days (3.5 months)
Dying RBCs are engulfed by _____
macrophages
Globin metabolizes into _____ _____
amino acids
Heme is degraded into _____
bilirubin
What is anemia?
blood has an abnormally low O2-carrying capacity
Symptoms of anemia include:
- fatigue
- pallor
- dyspnea
- chills
What anemias are caused by blood loss?
- acute hemorrhagic anemia: rapid blood loss
- chronic hemorrhagic anemia: hemorrhoids, ulcers
What anemias are caused by low RBC count?
- iron deficiency anemia: produces microcytes (small RBCs)
- pernicious anemia: autoimmune disease that destroys intrinsic factor (absorbs B12), produces macrocytes
- renal anemia: lack of EPO in kidneys
What anemias are caused by RBCs being destroyed?
- thalassemias: one faulty/absent globin chain resulting in thin RBCs
- sickle-cell anemia: hemoglobin S (mutated) results in crescent shaped RBCs
- polycythemia: excess of RBCs, resulting in sluggish blood
How do leukocytes leave capillaries?
diapedesis
What is leukocytosis?
- WBC count over 11,000 microliters
- normal infectious response
What are the 3 granulocytes?
- neutrophils
- eosinophils
- basophils
What are the 2 agranulocytes?
- lymphocytes
- monocytes
Decreasing abundance in blood:
Never Let Monkeys Eat Bananas
neutrophils, lymphocytes, monocytes, eosinophils, basophils
Neutrophils are very phagocytic. They are referred to as “_____ _____”
bacteria slayers
What granulocyte plays a role in allergies as well as releases enzymes on parasitic viruses?
eosinophils
What granulocyte contains histamine and appears purplish black?
basophils
Which agranulocyte is mostly found in lymphoid tissue?
lymphocytes
Which agranulocyte is phagocytic?
monocytes
What are T lymphocytes?
T cells that fight tumor and virus-infected cells
What are B lymphocytes
B cells that make plasma cells to produce antbodies
T lymphocytes mature in the _____
thymus
B lymphocytes mature in _____ _____ _____
red bone marrow
What is a low WBC count called?
leukopenia
What is acute leukemia?
derives from stem cells and affects children
What is chronic leukemia?
prevalent in old people
What is infectious mononucleosis?
mono, Epstein Barr virus