Chapter 16-Innate Immunity:Nonspecific Defenses Of Host Flashcards
Susceptibility:
Lack of resistance to disease
4 Nonspecific defenses of the host?
- susceptibility
- immunity
- innate immunity
- adaptive immunity
Immunity:
Ability to ward off disease
Innate immunity:
Nonspecific immunity defenses that protect against any pathogen
Adaptive immunity:
Specific immunity block or isolate from letting specific pathogen in.
First line of defense examples:
- intact skin
- mucous membranes
- normal microbiota
Second line of defense:
- natural killer cells and phagocytic white blood cells
- inflammation
- fever
- antimicrobial substance
Third line of defense:
- specialized lymphocytes: T & B cells
- antibodies
First line defense- 8 mechanical factors?
- intact skin
- mucous membranes
- lacrimal apparatus
- saliva
- ciliary escalator
- epiglottis
- urine
- vaginal secretions
Intact skin:
Epidermis consists of tightly packed cells with many layers, keratin top layer, dryness, shedding.
Mucous membranes:
Contain mucous to trap particles
Lacrimal apparatus:
Produces continued washing that removes pathogens
Saliva:
Produced by salivary glands
Ciliary escalator:
Produces mucous.
Microbes are trapped in the mucous and are transported away from the lungs.
Epiglottis:
Covers larynx to keep microbes out of the lower respiratory
Urine:
Cleanses urethra
Vaginal secretions:
Cleans vagina
First line- 4 chemical factors:
- sebum
- perspiration
- gastric juice
- transferrins
Sebum:
Oily substance produced by sebaceous glands.
- forms protective coating
- fatty acids I honor growth
- lowers pH (3-5) of skin
Perspiration:
Sweet glands.
- flushes away microbes
- contains lysozome
Gastric juice:
Produced by gastric glands.
- very acidic(1.2-3.0)
- kills most bacteria and toxins
Transferrins:
Proteins that bond iron I the blood reduce free hours so bacteria won’t get it.
No inhibits ATP production. True or false?
True
First line defense-normal microbiota protects the host by:
- Completion of nutrients
- Production of toxic substances
- Alternating the environment