Chapter 16 Flashcards

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1
Q

The cell walls of bacteria are made of a copolymer of
Question 1 options:

proteins and lipids.

proteins and polysaccharides.

polysaccharides and peptides.

cellulose and lignin

A

a

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2
Q

Which of the following antibiotics inhibits the synthesis of bacterial cell walls?
Question 2 options:

Penicillin

Streptomycin

Tetracyclin

Actinomycin D

A

a

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3
Q

The polysaccharide chains of bacterial cell walls are made of alternating
Question 3 options:

N-acetylgalactose and N-acetylmuramic acids.

N-acetylglucosamine and N-acetylmuramic acids.

N-acetylglucosamine and N-acetylneuraminic acids.

N-acetyl galactose and N-acetylneuraminic acids.

A

a

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4
Q

Fungal cell walls are built primarily of
Question 4 options:

cellulose.

peptidoglycan.

pectin.

chitin.

A

a

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5
Q

Plant cell walls consist of cellulose fibrils in a matrix of
Question 5 options:

chitin and pectin.

pectin and hemicellulose.

Pectin and lignin.

lignin and chitin.

A

a

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6
Q

The structural polysaccharide of fungal cell walls is the same as the one found in insect
Question 6 options:

exoskeletons.

endoskeletons.

eyes.

cartilage.

A

a

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7
Q

Pectins form a _______ network in plant cell walls.
Question 7 options:

fibrous

gel-like

solid, rigid

waxy

A

a

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8
Q

Cellulose synthase in plants is located
Question 8 options:

in the Golgi apparatus.

in the cytosol.

in the plasma membrane.

outside the cell.

A

a

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9
Q

The direction of cellulose microfibril synthesis in elongating plant cells is
Question 9 options:

parallel to the direction of cell elongation.

perpendicular to the direction of cell elongation.

perpendicular to the direction of microtubules under the plasma membrane.

parallel to the endoplasmic reticulum under the plasma membrane.

A

a

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10
Q

The thin, sheetlike basal laminae are found
Question 10 options:

under epithelia.

in the cytoplasm just below the plasma membrane.

in the extracellular space surrounding all eukaryotic cells.

in between adjacent cells connected by gap junctions.

A

a

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11
Q

The major protein of the extracellular matrix of animal cells is
Question 11 options:

keratin.

fibronectin.

collagen.

chondroitin sulfate.

A

a

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12
Q

Collagens commonly contain the three repeating amino acids: proline,
Question 12 options:

glutamine, and hydroxyproline.

glycine, and hydroxyproline.

glycine, and hydroxylysine.

glutamine, and hydroxylysine.

A

a

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13
Q

Basal laminae are a meshwork of fibrils composed primarily of type _______ collagen.
Question 13 options:

I

II

III

IV

A

a

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14
Q

The smallest amino acid is
Question 14 options:

glycine.

proline.

cysteine.

asparagine.

A

a

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15
Q

Vitamin C deficiency may lead to scurvy, a disease characterized by skin lesions and blood vessel hemorrhages due to weakened connective tissue. Vitamin C deficiency has this effect because the vitamin is
Question 15 options:

a critical structural component of collagen.

required for the enzymatic activity of prolyl hydroxylase.

required for the enzymatic activity of cellulose synthase.

required for the enzymatic activity of hydroxyprolyl hydroxylase.

A

a

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16
Q

Connective tissue cells are connected to the extracellular matrix by receptors that bind to an adhesive protein called
Question 16 options:

fibronectin.

aggrecan.

integrin.

lamin.

A

a

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17
Q

Integrins are
Question 17 options:

transmembrane proteins.

peripheral membrane proteins.

components of the extracellular matrix.

components of a desmosome.

A

a

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18
Q

Integrins bind to
Question 18 options:

collagen, laminin, and fibronectin.

plectin and proteoglycans.

α-actinin, vinculin, and talin.

All of the above

A

a

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19
Q

The major cell surface receptor(s) responsible for the attachment of cells to the extracellular matrix is(are)
Question 19 options:

hemidesmosomes.

desmosomes.

integrins.

laminin.

A

a

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20
Q

Cell adhesion molecules can be divided into four major groups. Which of the following is not one of those groups?
Question 20 options:

Selectins

Integrins

Collagens

Immunoglobulin superfamily

A

a

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21
Q

The major family of calcium-mediated cell-surface adhesion molecules is
Question 21 options:

calmodulins.

calsequestrins.

cadherins.

fibronectins.

A

a

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22
Q

If developing pre-nerve cells expressing only N-cadherin on their surfaces were mixed with epithelial cells expressing only E-cadherin, what would be the most likely result?
Question 22 options:

All cells would mix and adhere to one another equally.

Nerve cells would adhere to one another, and epithelial cells would adhere to one another.

Nerve cells would adhere to one another in the center, and epithelial cells would surround them.

Epithelial cells would adhere to one another in the center, and nerve cells would surround them.

A

a

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23
Q

Adherens junctions are linked to cytoplasmic
Question 23 options:

actin filaments.

intermediate filaments.

microtubules.

myosin filaments.

A

a

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24
Q

Desmosomes are linked to cytoplasmic
Question 24 options:

actin filaments.

intermediate filaments.

microtubules.

myosin filaments.

A

a

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25
Q

Which of the following molecules mediate the association of actin filaments with the cadherins in an adherens junction?
Question 25 options:

Plakoglobulins

Plectins

Talins

α- and β-catenin

A

a

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26
Q

Desmosomes are held together by the adhesion of the two desmosomal cadherins:
Question 26 options:

desmoglein and desmocollin.

desmoglein and desmoplakin.

desmoglobin and desmocollin.

desmoglobin and desmoplakin.

A

a

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27
Q

A junctional complex consists of a tight junction associated with both adherens junctions and
Question 27 options:

desmosomes.

gap junctions.

hemidesmosomes.

focal adhesions.

A

a

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28
Q

The function of gap junctions is to
Question 28 options:

hold epithelia together.

seal the space between cells.

provide direct communication between cells.

maintain the spacing of the basal laminae beneath epithelial cells.

A

a

29
Q

Which of the following can pass through gap junctions?
Question 29 options:

cAMP and calcium ions

Insulin and calcium ions

cAMP and glucose

Insulin and glucose

A

a

30
Q

All of the following can be due to a mutation in a gene for a gap junction protein except
Question 30 options:

Charcot-Marie-Tooth disease.

deafness.

cataracts.

scurvy.

A

a

31
Q

Adhesion of plant cells is mediated by a pectin-rich region of the cell wall called the
Question 31 options:

external lamina.

middle lamella.

intermediate lamella.

plasmodesmata.

A

a

32
Q

The communicating junctions between plant cells are called
Question 32 options:

gap junctions.

plasmodesmata.

plasmotubules.

lamellar junctions.

A

a

33
Q

Within the plant cell wall, cellulose microfibrils are embedded in a matrix consisting of proteins and two other types of polysaccharides: _______ and _______.

Question 33 options:

A

a

34
Q

The amino acid sequence of a collagen triple helix domain consists of Gly-X-Y repeats, in which X is frequently _______ and Y is frequently _______.

Question 34 options:

A

a

35
Q

Basal laminae are formed primarily from type IV collagen and other proteins.

A

t/f

36
Q

The fibrous proteins of the extracellular matrix are embedded in polysaccharide gels formed of glycosaminoglycans.

A

t/f

37
Q

Aggrecan is a large proteoglycan consisting of about 100 hyaluronan chains extending from a core protein.

A

t/f

38
Q

Integrins are homodimers of two transmembrane polypeptide subunits.

A

t/f

39
Q

Integrin was first localized to sites of cell adhesion to the extracellular matrix by immunofluorescence microscopy.

A

t/f

40
Q

Cell adhesion mediated by selectins, integrins, and most cadherins requires divalent cations.

A

t/f

41
Q

Loss of E-cadherin can lead to the development of a cancer.

A

t/f

42
Q

Adherens junctions and desmosomes both link to intermediate filaments in cells.

A

t/f

43
Q

Tight junctions provide strong adhesions between cells.

A

t/f

44
Q

Tight junctions involve a fusion between the outer leaflets of two membranes in the region of the junction.

A

t/f

45
Q

Tight junctions are located around the entire circumference of the cell.

A

t/f

46
Q

Charcot-Marie-Tooth disease is a tight junction disease.

A

t/f

47
Q

Plasmodesmata contain a single microtubule running from cell to cell down their center.

A

t/f

48
Q

Plasmodesmata can open and close in response to signals.

A

t/f

49
Q

What prevents collagen from assembling into fibrils inside the cell?

A

a

50
Q

Why is the term “basal lamina” preferred over the term “basement membrane”?

A

a

51
Q

Describe the structure of laminins.

A

a

52
Q

What is the function of plectin?

A

a

53
Q

Describe two ways in which a hemidesmosome differs from a desmosome.

A

a

54
Q

Which proteins attach integrins to actin filaments at focal adhesions?

A

a

55
Q

Describe the structure of an integrin, as determined from the cDNA sequence isolated from fibroblasts by Hynes et al.

A

a

56
Q

Describe the process of adhesion between leucocytes and endothelial cells that allows leucocytes to leave the circulation and enter an inflamed tissue.

A

a

57
Q

What are the four classes of cell adhesion molecules?

A

a

58
Q

What are the three cell-to-cell junctions found in the junctional complex between two intestinal epithelial cells?

A

a

59
Q

What is the primary function of tight junctions?

A

a

60
Q

What is a secondary function of tight junctions?

A

a

61
Q

How many molecules of the gap junction protein form one open channel between two cells?

A

a

62
Q

How do the hexagonal units of connexin form a junction through which molecules can diffuse?

A

a

63
Q

What is the function of gap junctions in heart muscle?

A

a

64
Q

What are the three most common disease consequences of connexin gene mutations?

A

a

65
Q

Why does a mutation in a gene for the gap junction protein not affect gap junction function in all tissues that have gap junctions?

A

a

66
Q

Why does any mutation in a gap junction protein produce defects in gap junction functions in sensitive tissues? Give two possible explanations.

A

a

67
Q

What are plasmodesmata?

A

a

68
Q

How do plasmodesmata form?

A

a