Chapter 15 - The Chromosomal Basis of Inheritance Flashcards
mendel’s law
segregation and independent assortment of chromosomes during meiosis
law of segregation
two alleles of each gene separate during gamete formation
law of independent assortment
alleles of genes on nonhomologous chromosomes assort independently during gamete formation
linked genes
inherited together b/c located near each other on same chromosome
nondisjunction
pairs of homologous chromosomes do not separate normally during meiosis (one gamete receives two of the same type of chromosome and other receives no copy)
aneuploidy
nondisjunction occurs from gamete fertilization (down syndrome is an aneuploid resulting in trisomic of chromosome 21)
monosomic zygote
only one copy of a particular chromosome
trisomic zygote
three copies of a particular chromosome
deletion
removes a chromosomal segment
inversion
reverse a segment within a chromosome
duplication
repeats a segment
translocation
moves a segment (exchange fragments)
chronic myelogenous leukemia is translocation of chromosomes 22 and 9