CHAPTER 15: Sleep Apnea and Sleep Disorders Flashcards
The idea of obesity is written by Charles Dickens in…
The Posthumous Papers of the Pickwick Club (1837)
Sound generated by the vibration of the pharyngeal soft tissues
Snoring
TRUE or FALSE
Snoring is often louder during inspiration than expiration
TRUE
A cessation of airflow for at least 10sec
Apnea
A reduction in airflow (>30%) at least 10sec with >4% oxyhemoglobin desaturation
Hypopnea
A reduction in airflow (>50%) at least 10sec with >3% oxyhemoglobin desaturation or an electroencephalogram (EEG) arousal
Hypopnea
Sequence of breaths for at least 10sec with increasing respiratory effort or flattening of the nasal pressure waveform, leading to an arousal from sleep when the sequence of breaths does not meet the criteria of an apnea or a hypopnea
Respiratory effort-related arousal (RERA)
Continued thoracoabdominal effort in the setting of partial or complete airfloe cessation
Obstructive
The lack of thoracoabdominal effort in the setting of partial or complete cessation of airflow
Central
A respiratory event with both obstructive and central features, with mixed events generally beginning as central events and ending with thoracoabdominal effort without airflow
Mixed
Used to described patients who do not meet the criteria for OSA syndrome but who experience excessive daytime somnolence and other debilitating somatic complaints
Upper Airway Resistance Syndrome (UARS)
Characterized by respiratory effort-related arousals
Upper Airway Resistance Syndrome
Is detected by esophageal pressure manometry, which reveals a pattern of progressively increasing negative esophageal pressure followed by an arousal
Respiratory effort-related arousals
Diagnostic criteria for OSA in adults requires a polysomnogram or home sleep apnes test (HSAT) that demostrates either…
- 5 or more predominately obstructive respiratory events (obstructive and/or mixed apneas, hypopneas, or RERAs)
- 15 or more predominately respiratory events per hour of sleep regardless of symptoms or comorbidities
Symptoms related to OSA
- Excessive daytime somnolence
- Waking with gasping
- Choking
- Breath holding
- Witnessed reports of apneas
- Loud snoring
Comorbidities include
- Hypertension
- Mood disorder
- Congnitive dysfunction
- Coronary artery disease
- Stroke
- Congestive heart failure
- Atrial fibrillation
- Type II DM
Number of apneas per hour of total sleep time
Apnea index
Number of hypopneas per hour of total sleep time
Hypopnea index
Number of apneas and hypopneas per hour of total sleep time
Apnea-hypopnea index
Number of RERAs per hour of total sleep time
Respiratory effort-related arousal index
Number of apneas, hypopneas, and RERAs per hour of total sleep time
Respiratory disturbance index
Number of central apneas per hour of total sleep time
Central apnea index
Number of mixed apneas per hour of total sleep time
Mixed apnea index
TRUE or FALSE
Diagnosis of OSA may be made on in-lab PSG or by HSAT
TRUE
Symptoms of Sleep-Disordered Breathing
- Restless sleep
- Loud snoring
- Observed apnea, choking, or gasping episodes
- Excessive daytime sleepiness
- Morning fatigue or irritability
- Memory loss
- Decreased cognitive function
- Depression
- Personality or mood changes
- Decreased libido and impotence
- Morning and nocturnal headaches
- Nocturnal sweating
- Nocturnal enuresis
Mild OSA
5-15 events per hour
Moderate OSA
15-30 events per hour
Severe OSA
30 events or more
4 key traits or phenotypes that contribute to OSA
- Impaired upper airway anatomy that is narrow or collapsible
- Low respirtory arousal threshold
- Inadequate responsiveness of upper airway dilator muscles during sleep
- Unstable or overly sensitive respiratory control, a concept referred to as high loop gain