CHAPTER 15: Sleep Apnea and Sleep Disorders Flashcards
The idea of obesity is written by Charles Dickens in…
The Posthumous Papers of the Pickwick Club (1837)
Sound generated by the vibration of the pharyngeal soft tissues
Snoring
TRUE or FALSE
Snoring is often louder during inspiration than expiration
TRUE
A cessation of airflow for at least 10sec
Apnea
A reduction in airflow (>30%) at least 10sec with >4% oxyhemoglobin desaturation
Hypopnea
A reduction in airflow (>50%) at least 10sec with >3% oxyhemoglobin desaturation or an electroencephalogram (EEG) arousal
Hypopnea
Sequence of breaths for at least 10sec with increasing respiratory effort or flattening of the nasal pressure waveform, leading to an arousal from sleep when the sequence of breaths does not meet the criteria of an apnea or a hypopnea
Respiratory effort-related arousal (RERA)
Continued thoracoabdominal effort in the setting of partial or complete airfloe cessation
Obstructive
The lack of thoracoabdominal effort in the setting of partial or complete cessation of airflow
Central
A respiratory event with both obstructive and central features, with mixed events generally beginning as central events and ending with thoracoabdominal effort without airflow
Mixed
Used to described patients who do not meet the criteria for OSA syndrome but who experience excessive daytime somnolence and other debilitating somatic complaints
Upper Airway Resistance Syndrome (UARS)
Characterized by respiratory effort-related arousals
Upper Airway Resistance Syndrome
Is detected by esophageal pressure manometry, which reveals a pattern of progressively increasing negative esophageal pressure followed by an arousal
Respiratory effort-related arousals
Diagnostic criteria for OSA in adults requires a polysomnogram or home sleep apnes test (HSAT) that demostrates either…
- 5 or more predominately obstructive respiratory events (obstructive and/or mixed apneas, hypopneas, or RERAs)
- 15 or more predominately respiratory events per hour of sleep regardless of symptoms or comorbidities
Symptoms related to OSA
- Excessive daytime somnolence
- Waking with gasping
- Choking
- Breath holding
- Witnessed reports of apneas
- Loud snoring
Comorbidities include
- Hypertension
- Mood disorder
- Congnitive dysfunction
- Coronary artery disease
- Stroke
- Congestive heart failure
- Atrial fibrillation
- Type II DM
Number of apneas per hour of total sleep time
Apnea index
Number of hypopneas per hour of total sleep time
Hypopnea index
Number of apneas and hypopneas per hour of total sleep time
Apnea-hypopnea index
Number of RERAs per hour of total sleep time
Respiratory effort-related arousal index
Number of apneas, hypopneas, and RERAs per hour of total sleep time
Respiratory disturbance index
Number of central apneas per hour of total sleep time
Central apnea index
Number of mixed apneas per hour of total sleep time
Mixed apnea index
TRUE or FALSE
Diagnosis of OSA may be made on in-lab PSG or by HSAT
TRUE
Symptoms of Sleep-Disordered Breathing
- Restless sleep
- Loud snoring
- Observed apnea, choking, or gasping episodes
- Excessive daytime sleepiness
- Morning fatigue or irritability
- Memory loss
- Decreased cognitive function
- Depression
- Personality or mood changes
- Decreased libido and impotence
- Morning and nocturnal headaches
- Nocturnal sweating
- Nocturnal enuresis
Mild OSA
5-15 events per hour
Moderate OSA
15-30 events per hour
Severe OSA
30 events or more
4 key traits or phenotypes that contribute to OSA
- Impaired upper airway anatomy that is narrow or collapsible
- Low respirtory arousal threshold
- Inadequate responsiveness of upper airway dilator muscles during sleep
- Unstable or overly sensitive respiratory control, a concept referred to as high loop gain
TRUE or FALSE
Obesity, soft tissue hypertrophy, and craniofacial characteristics such as retrognathia contribute to the upper airway anatomy by increasing the extraluminal tissue pressures surrounding the upper airway
TRUE
TRUED or FALSE
Patients without anatomic abnormalities may also have OSA
TRUE
3 major areas of obstruction
- Nose
- Palate
- Hypopharynx
Classification of patterns of obstruction by anatomic location: Type I
Collapse in the retropalatal region only
Classification of patterns of obstruction by anatomic location: Type II
Collapse in both retropalatal and retrolingual regions
Classification of patterns of obstruction by anatomic location: Type III
Collapse in the retrolingual region only
Major risk factor for OSA
Obesity
TRUE or FALSE
The increase fat deposition around the neck and parapharyngeal spaces is postulated to narrow and compress the upper airway and may offset the effects if dilator muscles that maintain airway patency
TRUE
TRUE or FALSE
Obesity contribute to OSA through its deleterious effects on metabolism, ventilation, and lung volume, resulting in a mismatch between alveolar ventilation and pulmoary perfusion
TRUE
Changes in lung volume significantly reduce pharyngeal upper airway size through the mechanical effect of tracheal and thoracic traction
Tracheal tug
Major cause of OSA in children
Adenotonsillar hypertrophy
Craniofacial variations that have been associated with OSA
- Increased distance of the hyoid bone from the mandibular plane
- Decreased mandibular and maxillary projection
- Downward and posterior rotation of mandibular and maxillary growth
- Increased vertical facial length
- Increased vertical length of the posterior airway
- Increased cervical angulation
TRUE or FALSE
To quantify the functional collapsibility of the upper airway, the passive criticla closing pressure (Pcrit) is measured using a mask attached to a device that can deliver both positive and negative airway pressure
TRUE
Is the luminal pressure at which the upper airway collapses after a prolonged period of therapeutic positive pressure, such that there is minimal recruitment of the pharyngeal dilator muscles when airway pressures are suddenly reduced
Passive critical closing pressure (Pcrit)
Pcrit of individuals with OSA
Pcrit above atmospheric pressure
Pcrit of individuals without OSA
Pcrit below -5 cm H2O
TRUE or FALSE
Neuromuscular tone contributes to the patency of the upper airway
TRUE
Considered to be the most important muscle in maintaining airway patency in OSA
Genioglossus
The sensitivity of the respiratory control system to perturbations in CO2 level
Concept of loop gain
Indicates an unstable respiratory control system that is prone to overcompensation, resulting in excessive changes in ventilation
High loop gain
Indicates a more stable respiratory control system where responses to perturbation are less prone to overcompensation, resulting in a more rapid return to homeostasis
Low loop gain
TRUE or FALSE
High loop gain can contribute to OSA by causing rapid increases in respiratory drive in response to small increases in CO2, resulting in large negative luminal negative pressures and increasing the likelihood of airway collapse
TRUE
Negative health effects attributed to untreated OSA
- Increased mortality
- Increase in cardiovascular disease
- Neurocognitive difficulties
Independent risk factor for insulin resistance
Untreated OSA
Most common symptoms of OSA
- Loud snoring
- Restles sleep
- Daytime hypersomnolence
Most common finding in patient with OSA
Obesity
Widely used tool that assesses daytime sleepiness
Epworth Sleepiness Scale
TRUE or FALSE
OSA may be suspected in patients with an ESS score greater than 10
TRUE
STOP-BANG
S- snor T- tired O- observed you stop breathing P- high blood pressure B- BMI A- age (50) N- neck circumference (>40 cm/female, >43 cm/male) G- gender (male)
Physical examination findings: Nasal obstruction
- Septal deviation
- Turbinate hypertrophy
- Nasal valve collapse
- Adenoid hypertrophy
- Nasal tumors or polyps
Physical examination findings: Oropharyngeal obstruction
- Large soft palate
- Palatine tonsillar hypertrophy
- Posterior pharyngeal wall banding
- Macroglossia
- Large mandibular tori
- Narrow skeletal arch
Physical examination findings: Hypopharyngeal obstruction
- Lateral pharyngeal wall collpase
- Omega-shaped epiglottis
- Hypopharyngeal tumor
- Lingual tonsillar hypertrophy
- Retrognathia and micrognathia
Physical examination findings: Laryngeal obstruction
- True vocal cord paralysis
2. Laryngeal tumor
Physical examination findings: General neck obstruction
- Increased neck circumference
2. Redundant cervical adipose tissue
Physical examination findings: General body habitus
- Obesity
- Achondroplasia
- Chest wall deformity
- Marfan syndrome
Physical examination findings: Cardiovascular signs
- Arterial hypertension, especially morning hypertension
2. Peripheral edema
Is performed in an awake patient, who generates negative pressure buy inhaling against a closed glottis with the nose and mouth closed to trigger airway collapse
Muller maneuver
Agent for sedation for DISE for adults
Midazolam and profopol
Agents for seadtion of DISE in children
Dexmedetomidine
A proposed method of standardizing DISE findings
V- velum
O- oropharynx
T- tongue base
E- epiglottis
Radiologic technique used to aid in the identification of the site and severity of upper airway obstruction or collapse in OSA
Cephalometric radigraph
TRUE or FALSE
The differences between OSA and non-OSA patients noted on cephalometry have not been significant enough to allow for the use of lateral cephalograms as a sole diagnostic tool
TRUE
Provides good anatomic detail of the bone and soft tissue
Awake CT
Primary advantage of CT
Highn anatomic resolution of dynamic airway movement during sleep without the presence of an endoscope that might potentially alter inflow
Provided excellent soft tissue differentiation and does not require radiation exposure
MRI