Chapter 15 - Neurocognitive disorders and ageing Flashcards
What are neurocognitive disorders?
Significantly reduced mental abilities, relative to one’s prior level of functioning. Changes in cognitive functioning are the primary set of features.
Often associated with increased anxiety and depression as secondary features.
What are the three types of neurocognitive disorders?
- Delirium
- Amnestic disorder
- Dementia
What is delirium?
Impaired cognition and a marked change in awareness.
What characterizes amnestic disorder?
Impaired memory while other mental processes remain intact.
What is dementia?
Impaired memory plus one other impaired cognitive function such as perception, attention, or language use.
What are the two types of intelligence in normal aging?
- Crystallized Intelligence
- Fluid Intelligence
Define crystallized intelligence.
Relies on using knowledge to reason; assessed with verbal ability tests.
Define fluid intelligence.
Relies on the ability to create new strategies to solve new problems; assessed with visual-motor skills, problem solving, and perceptual speed.
At what age do test scores for cognitive functioning typically decline?
Scores decline at age 55, more significantly at 65.
What is the duration of transient memory impairment in amnestic disorder?
Lasting a few days to a maximum of one month.
What is confabulation?
Creating stories to fill in gaps in memory.
What are common causes of amnestic disorder?
- Substance use
- General medical conditions
What is delirium often described as?
A clouded state of consciousness.
What are common symptoms of delirium?
- Trouble concentrating
- Vivid nightmares
- Perceptual disturbances
- Erratic emotional states
What medical factors can affect cognition?
- Head injuries
- Prescribed and illicit substances
- Chronic medical conditions
What is a stroke?
Interruption of normal blood flow to or within the brain, resulting in neuronal death.
What are the two types of aphasia associated with strokes?
- Broca’s aphasia
- Wernicke’s aphasia
What is the hallmark of Broca’s aphasia?
Problems in producing speech.
What is the hallmark of Wernicke’s aphasia?
Problems in both comprehension of language and meaningful utterances.
What are neurofibrillary tangles?
Mass created by tau proteins becoming twisted together, destroying microtubules in neurons.
What are amyloid plaques?
Fragments of protein that accumulate on the outside surfaces of neurons, particularly in the hippocampus.
What is vascular dementia?
Caused by reduced or blocked blood supply to the brain.
What gene is associated with early-onset Alzheimer’s disease?
A gene controlling the protein responsible for the formation of beta-amyloid found on chromosome 21.
What protective factors may reduce the risk of developing Alzheimer’s?
- Non-steroidal anti-inflammatory drugs
- Nicotine