Chapter 14 - Principles of Disease and Epidemiology Flashcards
is the invasion or colonization of the body by pathogenic microbes
Infection
Is when an infection changes the body’s state of health
Disease
the scientific study of disease
pathology
the cause of a disease
etiology
the way in which disease develops
pathogenesis
microbial communities of harmless and beneficial bacteria that inhabit the body
microbiomes
a subjective change in a body function experienced by the patient
symptom
EX: pain, changes in perception
symptom
an objective change in body function that a health professional can measure
Sign
EX: blood pressure, bruising
sign
collection of symptoms and signs associated with a specific disease
syndrome
defined as a disease that is capable of spreading from one host to another
communicable disease
EX: tuberculosis (is what type of disease?)
communicable disease
defined as a subset of communicable disease that is easily spread from one host to another
contagious disease
EX: Chicken pox (Is what type of disease?)
contagious disease
defined as a disease that does not spread from one host to another
non-communicable disease
EX: tetanus (is what type of disease?)
non-communicable disease
______ of a disease is the number of people who develop the disease during a specific time period
Incidence
ONLY measures new cases
Incidence
_____ of a disease is the number of people who have the disease during a specific time period
prevalence
Measures new and old cases
prevalence
disease that appears only occasionally in a population
sporadic disease
EX: typhoid fever (is classified under what disease type?)
sporadic disease
disease that is common within a population
endemic disease
EX: common cold, chicken pox (is classified under what disease type?)
endemic disease
a disease that many people in a regional population develop within a short time
epidemic disease
EX: influenza, bubonic plague (is classified under what disease type?)
epidemic disease
an epidemic disease on a global scale
pandemic disease
EX: AIDS (is classified under what disease type?)
pandemic disease
a disease normally occurring in animals that can be transmitted to humans
zoonosis
a condition where pathogens are spreading throughout the body
sepsis
a category of sepsis and refers to the presence of pathogens in the blood
septicemia
the presence of bacteria in the blood
bacteremia
presence of toxins in the blood
toxemia
presence of viruses in the blood
viremia
Microbes that inhabit the body but generally do not cause disease
normal microbiota/normal flora
Once normal microbiota are established on the body, they maintain conditions that limit opportunities for other microbes to infect the body
microbial antagonism
live microbial cultures designed to have a beneficial effect on the host
probiotics
What are four functions of microbial antagonism
- competition for nutrients and resources
- maintaining inhospital pHs
- controlling oxygen levels
- production of bacteriocins
proteins that kill off other bacteria
bacteriocins
defined as a relationship between two organisms where at least one organism is dependent on the other.
symbiosis
a form of symbiosis where one organism benefits from the relationship, while the other organism is unaffected
commensualism
a form of symbiosis where both organisms benefit from the relationship
mutualism
a form of symbiosis where one organism benefits from the relationship, but the other is harmed
parasitism
What symbiotic organisms can become parasitic by the change in location?
Mutualistic and commensalistic
microbes that do not cause disease in their normal habitat, but may do so in another region of the body
opportunistic pathogens
Robert Koch’s four postulates
- The same pathogen must be present in all cases of the disease.
- The pathogen must be able to be isolated from the host and grown in pure culture.
- The pathogen from the pure culture must be capable of causing disease in a healthy host.
- The pathogen must be isolated from the new host and demonstrated to be the same pathogen.
Exceptions for Koch’s Postulates
- Not all pathogens are capable of growing on standard culture media.
- Some pathogens require cells in order to reproduce. - Multiple pathogens may be able to cause the same disease.
- Examples: pneumonia, meningitis, peritonitis. - Some pathogens cause multiple diseases.
- Some pathogens are only pathogenic in humans.
- Infecting a healthy human with a pathogen has severe ethical concerns.
Duration of a disease
acute, subacute, chronic, and latent disease
a disease that develops quickly but lasts only a short time
acute disease
a disease that develops over time, but may recur on a regular basis
chronic disease
falls between an acute and chronic disease
subacute disease
a disease that takes longer to develop symptoms than a chronic disease
latent disease
an infection where the pathogens are limited to a small part of the body
local infection
EX: abscesses, wounds (what type of infection is this?)
local infection
an infection where the pathogens spread out through the entire body
systemic infection
EX: measles (what type of infection is this?)
systemic infection
an infection when the pathogens of a local infection spread to another specific part of the body
focal infection
an infection that causes the initial disease in a host
primary infection
an infection caused by opportunistic pathogens after a primary infection has weakened the host’s defenses
secondary infection
an infection that does not cause any noticeable illness of symptoms in the host
subclinical infection
an infection acquired in a hospital setting
nosocomial infection
5 Major stages of a disease
- incubation period
- prodromal period
- period of illness
- period of decline
- period of convalescence
the period between the first exposure to a pathogen and the first emergence of symptoms; a person does not show any signs or symptoms of sickness
Incubation period
pathogens continue to multiply but are still not formidable enough to cause fulminant illness. A person also begins to show signs of illness, but the symptoms are mild and not very specific or diagnostic
Prodromal period
When a person is highly contagious and experiencing fulminant symptoms
Period of illness
invading pathogens decrease in the body as the immune system combats the infection
period of decline
a period of recovery and return to the pre-illness state
period of convalescence
makes an individual more susceptible to developing a disease
predisposing factor
continual source of pathogens, for the pathogen to survive and multiply
reservoir
Transmission of the pathogen from the reservoir to the host has three main mechanisms
- contact
- vehicle
- vectors
contact transmission has three varieties
direct contact transmission, indirect contact transmission, and droplet transmission
involves direct contact between the reservoir and the host
direct contact transmission
involves transmission between the reservoir and host through a fomite, or non-living object capable of transmitting the pathogen (overlaps the vehicle transmission)
indirect contact transmission
involves transmission of pathogens through tiny droplets expelled from the reservoir over distances less than one meter
droplet transmission
involves transmission between the reservoir and host through a non-living medium (water, air, food)
vehicle transmission
involves transmission between the reservoir and host through a living organism
vector transmission
or insects, are the most common vectors
arthopods
occurs through passive contact of the insects body with the reservoir and host
mechanical transmission
occurs when the insect bites an infected animal or person, then transfers the pathogen to a healthy individual
biological transmission
include infections from other health care facilities
HAI (Health-care associated infections)
3 major causes of nosocomial infections
- prevalence of microbes
- compromised hosts
- opportunities for transmission
Emerging Infectious diseases
New strains through mutation or recombination
Environmental changes
Modern transportation
Changes in animal populations
Public health issues
Rise of antibiotic resistance
Natural and manmade disasters
is the study of the occurrence of diseases, and their transmission.
epidemiology
Three types of epidemiological studies
-descriptive epidemiology
-analytical epidemiology
-experimental epidemiology