Chapter 14 Flashcards

1
Q

Any substance or microorganism that causes disease or damage to the tissues of the body

A

Pathogen

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2
Q

Functions of the lymphatic system

A

Fluid balance
Lipid absorption
Defense

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3
Q

About 30 liters (L) of fluid pass from the blood capillaries into the interstitial space each day, whereas only 27 L pass from the interstitial spaces back into the blood. If the extra 3 L of interstitial fluid remained in the interstitial spaces, ___ would result, causing tissue damage and death. Instead, 3 L of fluid enters the lymphatic capillaries. Once inside the lymphatic capillaries, this fluid is called ___ and it passes through the lymphatic vessels.

A

Fluid balance - edema, lymph

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4
Q

Lymph contains solutes derived from 2 sources

A
  1. Substances in plasma - ions, nutrients, gases, and some proteins, pass from blood capillaries into the interstitial spaces, and then into lymphatic capillaries to become part of the lymph
  2. Substances such as hormones, enzymes, and waste products derived from cells within tissues, are also part of the lymph
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5
Q

The lymphatic vessels absorbs lipids and other substances from the digestive tract through lymphatic vessels called ___ located in the lining of the small intestine. Lipids enter the ___ (same) and pass through the lymphatic vessels to the venous circulation. The lymph passing through these lymphatic vessels appears white because of its lipid content and is called ___.

A

Lipid absorption - lacteal, chyle

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6
Q

Pathogens, such as microorganisms and other foreign substances, are filtered from lymph by ___ and from blood by the ___. In addition, ___ and other cells are capable of destroying pathogens.

A

Defense - lymph nodes, spleen, lymphocytes

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7
Q

The lymphatic system includes ___. (7)

A

Lymph, lymphocytes, lymphatic vessels, lymph nodes, tonsils, spleen, and thymus

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8
Q

T/F: The lymphatic system carries fluid in one direction, from tissues to the circulatory system.

A

T

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9
Q

Tiny, closed-ended vessels consisting of simple squamous epithelium that are more permeable than blood capillaries because they lack a basement membrane and fluid moves easily into them

A

Lymphatic capillaries

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10
Q

Where are lymphatic capillaries NOT FOUND?

A

Central nervous system, bone marrow, and tissues lacking blood vessels such as epidermis and cartilage

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11
Q

A ___ of lymphatic capillaries collects excess interstitial fluids from the dermis and subcutaneous tissue and a ___ collects excess fluid from muscle, the viscera, and other deep structures.

A

Superficial, deep

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12
Q

Three factors cause compression of lymphatic vessels

A
  1. Contraction of surrounding skeletal muscle during activity
  2. Periodic contraction of smooth muscle in lymphatic vessel wall
  3. Pressure changes in the thorax during breathing
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13
Q

Lymphatic vessels from the right upper limb and the right half of the head, neck, and chest form the ___ which empties into the ___.

A

Right lymphatic duct, right subclavian vein

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14
Q

Lymphatic vessels from the rest of the body enter the ___ which empties into the ___.

A

Thoracic duct, left subclavian vein

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15
Q

What are the lymphatic organs? (4)

A

Tonsils, lymph nodes, spleen, and thymus

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16
Q

It is characterized by housing many lymphocytes and other defense cells such as macrophages.

A

Lymphatic tissue

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17
Q

The lymphocytes originate from ___ and are carried to the blood by ___.

A

Red bone marrow, lymphatic organs

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18
Q

Three groups of tonsils

A

Palayine, pharyngeal, lingual

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19
Q

Located on each side of the posterior opening of the oral cavity; these are the ones usually referred to as the tonsils.

A

Palatine tonsils

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20
Q

Located near the internal opening of the nasal cavity.

A

Pharyngeal tonsil

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21
Q

When a pharyngeal tonsil is enlarged, it is commonly called the ___.

A

Adenoid

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22
Q

Located on the posterior surface of the tongue

A

Lingual tonsil

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23
Q

Removal of pharyngeal tonsils

A

Adenoidectomy

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24
Q

Removal of palatine tonsils

A

Tonsillectomy

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25
Rounded structures, varying from the size of a small seed to that of a shelled almond; distributes along the various lymphatic vessels.
Lymph nodes
26
Classification of lymph nodes
Superficial, deep
27
Three superficial aggregations of lymph nodes on each side of the body
1. Inguinal nodes in the groin 2. Axillary nodes in the axilla 3. Cervical nodes in the neck
28
A dense connecive tissue that surrounds each lymph node
Capsule
29
Extensions of the capsule that subdivide into compartments containing lymphatic tissue and lymphatic sinuses
Trabeculae
30
The lymphatic tissue consists of lymphocytes and other cells that can form dense aggregations of tissue called ___.
Lymphatic nodules
31
Areas of tissue within lymph nodes and other organs
Lymphatic nodules
32
Spaces between the lymphatic tissue that contain macrophages on a network of fibers
Lymphatic sinuses
33
Lymph enters the lymph node through ___ and exits through ___.
Afferent vessels, efferent vessels
34
As lymph moves through lymph nodes, two functions are performed.
1. Activate immune system | 2. Remove pathogens
35
Lymphatic nodules containing the rapidly dividing lymphocytes
Germinal centers
36
Roughly the size of clenched fist and is located in the left, superior corner of the abdominal cavity
Spleen
37
Trabeculae from the capsule divide the spleen into small, interconnected compartments containing two specialized types of lymphatic tissue
White pulp, red pulp
38
Lymphatic tissue surrounding the arteries within the spleen
White pulp
39
Lymphatic tissue associated with veins; consists of a fibrous network filled with macrophages and red blood cells, and enlarged capillaries that connect to the veins
Red pulp
40
The spleen filters ___ instead of lymph.
Blood
41
The spleen also functions as blood ___, holding a small volume of blood.
Reservoir
42
Cracks in the spleen are repaired using ___ and ___.
Sutures, blood-clotting agents
43
Removal of the spleen
Splenectomy
44
Bilobed gland roughly triangular in shape, located in the superior mediastinum.
Thymus
45
Trabeculae from the capsule divide the thymus into ___.
Lobules
46
Spleen: Near the capsule and trabeculae, lymphocytes are numerous and from dark-staining areas called ___.
Cortex
47
Spleen: A lighter-staining, central portion of the lobules called ___ has fewer lymphocytes.
Medulla
48
Site for T-cell maturation
Thymus
49
Filter lymph
Lymph nodes
50
Two types of lymphocytes
B cells, T cells
51
Originate and mature in red bone marrow
B cells
52
Ability to resist damage from pathogens
Immunity
53
Two systems of immunity
Innate/nonspecific resistance, adaptive/specific immunity
54
Characteristics of adaptive immunity
Specificity, memory
55
Ability of adaptive immunity to remember previous encounters with a particular substance
Memory
56
Mechanisms of innate immunity (4)
Physical barriers, chemical mediators, white blood cells, and inflammatory response
57
Physical barriers prevent pathogens and chemicals from entering the body through ___. (2)
(1) skin and mucous membranes that form barriers that prevent their entry; (2) tears, saliva, and urine that wash these substances off the body
58
Molecules responsible for many aspects of innate immunity. E.g., lysozyme, mucus, histamine, complement, prostaglandins, leukotrienes, interferons
Chemical mediators
59
Group of more than 20 proteins found in plasma
Complement
60
Proteins that protect the body against viral infections
Interferons
61
Most important cellular components of immunity; produced in red bone marrow
WBC
62
Ingestion and destruction of particles by phagocytes
Phagocytosis
63
Movement of white blood cells towards chemicals
Chemotaxis
64
Most important phagocytes
Neutrophils, macrophages
65
Small phagocytic WBCs that are usually the first to enter infected tissues from the blood in large numbers
Neutrophils
66
Accumulation of fluid, dead neutrophils, and other cells at the site of infection
Pus
67
Monocytes that leave the blood, enter tissue, and enlarge about fivefold
Macrophages
68
Monocytes and macrophages form the ___ because they are phagocytes with a single, unlobed nucleus.
Mononuclear phagocytic system
69
Macrophages in lungs
Dust cells
70
Macrophages in liver
Kupffer cells
71
Macrophages in the central nervous system
Microglia
72
Derived from red bone marrow; motile WBCs that can leave the blood and enter infected tissues.
Basophils
73
Derived from red bone marrow; nonmotile cells in connective tissue, especially near capillaries.
Mast cells
74
When activated, these cells release histamine and leukotrienes that produce an inflammatory response or activate other mechanisms.
Basophils and mast cells
75
Participate in inflammation associated with allergies and asthma
Eosinophils
76
Type of lymphocyte produced in red bone marrow; account for up to 15% of lymphocytes; recognize classes of cells such as tumor cells or virus-infected cells in general rather than specific tumor cells or cells infected by a specific virus; do not exhibit memory response - classified as part of innate immunity
Natural Killer (NK) cells
77
Involves many of the chemicals and cells; most are very similar although some details vary depending on the intensity of the response and the type of injury
Inflammatory response
78
Effects of histamine, prostaglandins, leukotrienes, complement, and kinins
1. Vasodilation increases blood flow and brings phagocytes and other WBCs to the area 2. Phagocytes leave the blood and enter the tissue 3. Increased vascular permeability allows fibrinogen and complement to enter the tissue from the blood
79
Further enhances the inflammatory response and attracts additional phagocytes
Complement
80
Inflammatory response confined to a specific area of the body; symptoms include redness, heat, swelling, pain, loss of function
Local inflammation
81
Inflammatory response that is generally distributed throughout the body
Systemic inflammation
82
Substances that stimulate adaptive immune responses
Antigens
83
Two groups of antigens
Foreign antigens, self-antigens
84
Introduced from outside the body; e.g., bacteria, viruses, chemicals; allergic reactions - pollen, animal hairs, foods, drugs
Foreign antigen
85
Molecules that the body produces to stimulate an immune system response
Self-antigen
86
Results when self-antigens stimulate unwanted destruction of normal tissue
Autoimmune disease
87
Divisions of adaptive immunity
Antibody-mediated immunity, cell-mediated immunity
88
Involves B cells and produces proteins called antibodies
Antibody-mediated immunity
89
Involves the actions of T cells
Cell-mediated immunity
90
Produce the effects of cell-mediated immunity
Cytotoxic T cells
91
Promote or inhibit the activities of both antibody-mediated immuity and cell-mediated immunity
Helper T cells
92
Capable of giving rise to all the blood cells
Stem cells
93
Small groups of identical B cells or T cells
Clones
94
For the adaptive immune response to be effective, two events must occur
1. Antigen recognition of lymphocytes | 2. Proliferation of lymphocytes recognizing the antigen
95
Lymphocytes have cell membrane proteins on their surfaces called ___.
Antigen receptors
96
Antigen receptors on B cells
B-cell receptors
97
Antigen receptors on T-cells
T-cell receptors
98
Glycoproteins that have binding sites for antigens
Major Histocompatibility complex (MHC)
99
Found on the membrane of most nucleated cells
MHC Class I
100
Found on the membranes of antigen-presenting cells, B lymphocytes, and other defense cells.
MHC Class II
101
The ___ function as serving trays that hold and present a processed antigen on the outer surface of the cell membrane.
MHC molecules
102
Costimulation can be achieved by ___ which are proteins or peptides secreted by one cell as a regulator of neighboring cells.
Cytokines
103
Helper T cells have a glycoprotein called ___.
CD4
104
An important process that generates the needed defense cells to protect the body.
Lymphocyte proliferation
105
Binds to receptors and stimulates the helper T cells to divide
Interleukin-2
106
Responsible for secondary response or memory response
Memory B cells