Chapter 14 Flashcards
Which of the following is not mediated by antibodies?
a. type I hypersensitivity
b. type II hypersensitivity
c. type III hypersensitivity
d. type IV hypersensitivity
e. None of the above
d. type IV hypersensitivity
Which of the following is associated with type III hypersensitivity?
a. nickel
b. recombinant human insulin
c. plant oil
d. mouse-derived monoclonal antibody
e. helminth infection
d. mouse-derived monoclonal antibody
_____ hypersensitivity reactions interact with soluble epitopes and not cell-surface associated epitopes.
a. type I and II
b. type I and III
c. type I and IV
d. type II and III
e. type II and IV
b. type I and III
During a primary immune response IgM sometimes switches to IgE. Which of the following best describes the consequence of this early switch?
a. The B cell would switch again to IgG3.
b. The B cell would remain in the germinal center but would not differentiate into a plasma cell.
c. The B cell would die by apoptosis.
d. The IgE produced would have low affinity for antigen.
e. The IgG produced would have low affinity for antigen.
d. The IgE produced would have low affinity for antigen.
Which of the following regarding FcepsilonRI is false?
a. It is expressed on the surface of mast cells and basophils.
b. It is a low-affinity receptor involved in type I hypersensitivity reactions.
c. It binds to IgE in the absence of antigen.
d. It is a membrane-bound tetramer.
e. It contains signaling components that re activated following antigen cross-linking.
b. It is a low-affinity receptor involved in type I hypersensitivity reactions.
The sheddase _____ cleaves FcepsilonRII on the cell surface, resulting in the production of monomeric and trimeric forms of FcepsilonRII.
a. cathepsin G
b. CR2
c. eotaxin
d. major basic protein
e. ADAM10
e. ADAM10
All of the following are released immediately by mast cells after FcepsilonRI cross-linking except _____.
a. heparin
b. eicosanoids
c. neutral proteases
d. histamine
e. TNF-alpha
b. eicosanoids
Lipid mediators produced by activated mast cells include which of the following?
a. platelet-activating factor, leukotrienes, and prostaglandins
b. cathepsin G
c. chymase
d. histamine
e. carboxypeptidase
a. platelet-activating factor, leukotrienes, and prostaglandins
All of the following are biological effects mediated by the products of mast cells except _____.
a. chemotaxis of neutrophils, eosinophils, and effector T cells
b. growth factor secretion
c. smooth muscle contraction
d. connective tissue remodeling
e. All of the above are mediated by mast cells.
e. All of the above are mediated by mast cells.
Identify the mismatched pair.
a. TNF-alpha: immediate release from mast cells
b. mucosal mast cell production: T-cell immunodeficiencies
c. connective tissue mast cells: chymotryptase
d. lipid mediator: prostaglandins
e. leukotrienes: increase vascular permeability
b. mucosal mast cell production: T-cell immunodeficiencies
Prostaglandin D2 (PGD2) enhances all of the following except _____.
a. chemotaxis of neutrophils
b. increased vascular permeability
c. vasodilation
d. chemotaxis of macrophages
d. chemotaxis of macrophages
Which of the following directly inhibits the cyclooxygenase pathway by inhibiting the activity of prostaglandin synthase?
a. ADAM10
b. experimental anti-IgE
c. aspirin (acetyl salicylate)
d. chymotryptase
e. ADAM33
c. aspirin (acetyl salicylate)
_____ released by TH2 cells promotes an elevated level of eosinophils in the circulation.
a. IL-4
b. IL-13
c. TNF-alpha
d. FcgammaRII
e. IL-5
e. IL-5
The antigens that provoke hypersensitivity reactions are referred to as ________.
a. T-independent antigens
b. superantigens
c. subunit vaccines
d. attenuated vaccines
e. allergens
e. allergens
Which of the following allergens is not likely to be encountered through inhalation?
a. plant pollen
b. metals
c. animal dander
d. mold spores
e. house dust mite feces
b. metals
