Chapter 14 Flashcards
Which of the following is an example of asymmetric cell division?
Stem cells dividing into pluripotent and differentiated forms
Which of the following changes are observed upon cyclin and CDK binding?
A conformational change is induced which activates the CDK
Which of the following events/proteins are NOT associated with prometaphase?
APC targeting of Smc2 for destruction
Which of the following is NOT regulated by APC?
Cyclin D
Apical, Chromosomal and Polar microtubules are necessary for completion of metaphase.
True
Which of the following is NOT involved in force generation during anaphase migration of chromosomes?
Dynein migration to the (+) end of the microtubule
Which of the following features would be observed in a cell that has entered into Telophase or Cytokinesis (select all that apply)?
A) The mitotic spindle is no longer assembled
B) The cleavage furrow is visible
C) Chromosomes are decondensed
D) The nuclear envelope reforms
A) The mitotic spindle is no longer assembled
B) The cleavage furrow is visible
C) Chromosomes are decondensed
D) The nuclear envelope reforms
A mitotic chromosome can be distinguished from a S phase chromosome by what (select all that apply)?
A) There is condensin bound to the chromosome
B) The DNA is extensivly supercoiled
C) Both sister chromatids are visible
D) The DNA does not contain histones
A) There is condensin bound to the chromosome
B) The DNA is extensivly supercoiled
C) Both sister chromatids are visible
Which of the following is a feature of MPF?
Regulates the transition into M phase
Which of the protein-function pairs listed below is incorrect?
A. APC –> degradation of cyclin E
B. CAK –> Phosphorylation of CDC2 on ty 161
C. CDC25 –> Phosphatase that activates CDC2
D. P21 –> activation of damage induced CDKs
APC –> degradation of cyclin E
If a cell is deficient in the spindle assembly checkpoint what would you expect the outcome to be (select all that apply)?
A. a higher occurrence of mitotic non-dysjunction
B. a higher frequency of syntelic attachment
C. Mad2 binding to cdc20
D. Inactivation of APC
A. a higher occurrence of mitotic non-dysjunction
B. a higher frequency of syntelic attachment
All of the following are motor proteins involved in mitosis EXCEPT?
Seperin
Which of the theses features would you expect to find in a sample taken from a patient with ataxia-telangiectasia?
Reduced transcription of P21
The energy for contractile ring activity is derived from what?
GTP hydrolysis
Which of the following cyclin/CDK pairs would be active during S/G2 transition?
Cyclin A/CDK2
The kinase ATR is activated following ionizing radiation
False
All cells undergo cell division at some point following differentiation
False
The formation of the metaphase plate is dependent on what (select all that apply)?
A. Addition of tubulin to the microtubule plus end
B. Depolymerization of the microtubule minus end
C. Shortening of the longer microtubules attached to one kinetochore
D. Elongation of the shorter microtubules attached to the kinetochore
B. Depolymerization of the microtubule minus end
C. Shortening of the longer microtubules attached to one kinetochore
D. Elongation of the shorter microtubules attached to the kinetochore
Which of the following is NOT a feature of cell cycle checkpoints?
Activate damage recognition proteins
Which of the following can be used to distinguish prometaphase from prophase (select all that apply)?
A. Microtubules are attached to the kinetacore
B. The nuclear envelop has begun to degrade
C. Mitotic spindle is assembled
D. Chromosomes are condensed
A. Microtubules are attached to the kinetacore
