Chapter 14 Flashcards
What is a symptom of bone that has two types, 1. Benign
(Asymptomatic, Grows slowly and by expansion: displaces teeth and expands the cortex, Symmetrical and Does not metastasize) and 2. Malignant (Usually symptomatic. Grows more rapidly, Invades and destroys adjacent structures (cortex), Often asymmetrical, Ragged or poorly defined margins and destroys cortex, Laying down bone outside the cortex, Capable of metastasis)?
What does this look like radiographically?
- Bone Neoplasia (Benign and Malignant)
- Usually has a Corticated rim [white rim] on a radiograph and can be just destroyed bone.
What is the MOST common type of inherited bone disease, Group of heritable disorders, Defect in type I collagen maturation, bone has a Thin cortex, Fine trabeculation and Diffuse osteoporosis. Signs and symptoms are Bone fragility, Blue sclera, Altered teeth, Hearing loss (hypoacusis), Long bone & spine deformities, and Joint hyperextensiblity? What do these look like radiographically? What differentiates the four main types?
- Osteogenesis Imperfecta
- Osteopenia (low bone density) and Bowing bones
- o Type I: Most common, mildest, blue sclera throughout life
o Type II: Not compatible with life
o Type III: Most severe form; 1/3 survive into adulthood
o Type IV: Resembles type I; slightly more severe (more fractures)
What is known as the marble bone disease, Skeletal disorder with a marked increase in bone density, Results from a defect in remodeling caused by a failure of normal osteoclast function? What are the two types and what makes them different? What does it look like radiographically?
- Osteopetrosis
- Infantile: Patients with osteopetrosis discovered at birth or early infancy = Malignant Osteopetrosis, Severe disease, Marrow failure, Frequent fractures, Cranial nerve compression, Facial deformities, Delayed tooth eruption, Osteomyelitis post tooth infraction.
- Adult: Discovered later in life and has less severe manifestations, AKA benign osteopetrosis, 40% are asymptomatic, Marrow failure is rare.
- Widespread increase in skeletal density (increased radiopaque) and Roots of teeth are difficult to visualize because of the density of the surrounding bone.
What is a syndrome complex, characterized by dental and clavicle abnormalities, also appears as an individual with a Short stature; big head, Pronounced frontal bossing, Ocular hypertelorism, a Broad base of nose, generalized super numerary teeth (lack of loss of primary teeth, etc.), and higher prevalence of cleft palate?
- Cleidocranial Dysplasia
What is an Area of hematopoietic marrow that produces a radiolucency, May be confused with an intraosseous neoplasm, Area of hematopoietic marrow that produces a radiolucency, May be confused with an intraosseous neoplasm and No jaw expansion?
- Focal Osteoporotic Marrow Defect
What is a Focal area of increased radiodensity that is of unknown cause and cannot be attributed to anything else and in Most cases arise in teenage years and remain static? **(Do not confuse with condensing osteitis, which is associated with an infection. Do not confuse with Focal Cemento-osseous Dysplasia, which will have a radiolucent rim. Do not confuse with Cementoblastoma, which will be fused with the tooth.)
- Idiopathic Osteosclerosis
What is Characterized by spontaneous and progressive destruction of one or more bones (Destroyed bone is initially replaced by a vascular proliferation), Affected area does not regenerate or repair; eventually the site of destruction is filled with a dense fibrous tissue, No known cause, Most patients are children/young adults and Mobile teeth, Pain, Malocclusion and Deviation of the mandible are all seen?
- Massive Osteolysis (AKA ‘Gorham disease’)
What is Relatively common disease characterized by abnormal resorption and deposition of bone, Results in distortion and weakening of affected bones, Affects more than one bone (polyostotic), Bone pain is a common complaint, Involvement of weight-bearing bones leads to a bowing deformity, resulting in a simian (monkeylike) stance, Patients have high elevations in serum alkaline phosphatase levels with NORMAL calcium and phosphorus levels and Teeth often have hypercementosis with a cotton roll/wool appearance? Severe cases result in what? *(Hat/dentures usually won’t fit)
- Paget’s Disease of Bone
- Leontiasis ossea, or lionlike facial deformity
What is Considered a nonneoplastic lesion, Some of which demonstrate aggressive behavior, More common in the anterior jaw; frequently cross the midline, Most are asymptomatic & discovered during routine XRAY or due to painless bone expansion and The histopathology is identical to a brown tumor of hyperparathyroidism (so patients MUST be evaluated for this condition) and lesions of cherubism?
- Central Giant Cell Granuloma
What is a Developmental jaw condition; with AD inheritance, the facial appearance is similar to that of plump-cheeked little angels, arises from bilateral involvement of the posterior mandible that produces chubby cheeks, There is an “eyes upturned to heaven” appearance due to a wide rim of exposed sclera noted below the iris, Disease occurs between the ages of 2-5, Clinical alterations progress until puberty, then stabilize & slowly regress, Mandibular lesions are painless, bilateral, posterior, and expansile, Causes marked widening and distortion of the alveolar ridges, May lead to failure of tooth eruption amongst other things, and Radiation therapy is contraindicated due to risk of post-irradiation sarcoma?
- Cherubism
What is a Benign, empty or fluid filled cavity within bone, where “Cyst” is a misnomer because the lesion does not have an epithelial lining, Trauma to the bone which is insufficient to cause a fracture results in intraosseous hematoma, If the hematoma does not undergo organization & repair, it may liquefy and result in a defect, usually found in long bones, in a radiograph when several teeth are involved, the defect shows domelike projections that scallop between the roots; this feature is highly suggestive?
- Traumatic Bone cyst (simple bone cyst ) **Teeth are left alone, cyst goes around teeth/roots. (Scalloping)
What is an Intraosseous accumulation of blood-filled spaces surrounded by connective tissue, NOT a true cyst; no epithelial lining, Typically seen in long bones, Most common clinical manifestation is a swelling that has developed rapidly, Pain is often reported, radiographically described is a “blow-out” or ballooning distention of the contour of the affected bone, The appearance is like a “blood-soaked sponge”?
- Aneurysmal bone Cyst
What is a Diverse group of processes characterized by replacement of normal bone by fibrous tissue containing a mineralized product, Microscopic lesions are very similar amongst different types of fibre-osseous lesions, and Therefore, clinical and radiographic finding are necessary to establish diagnosis? What are examples of benign forms of this?
- Fibro-Osseous Lesions
- Examples of BFOLs (benign fibro-osseous lesions):
o Fibrous dysplasia
o Cemento-osseous dysplasia
- Focal
- Periapical
- Florid
o Ossifying fibroma
What is a Tumor-like condition that is Characterized by replacement of normal bone by fibrous connective tissue intermixed with bone, Sporadic condition resulting from a post zygotic mutation, and Therefore, depending on when the mutation takes place, the process may involve: One bone (monostotic), Multiple bones (polyostotic), Skin, Endocrine system? There are two types of this dysplasia, what are they?
- Fibrous Dysplasia
- Monostotic and Polyostotic
There are two types of Fibrous Dysplasia, which one:
• Accounts for 80% of all cases, Jaws are among the most commonly affected sites, Usually diagnosed in teenage years, Painless, slowly-growing swelling of the affected area is the most common feature, Chief radiographic feature is a fine “ground-glass” opacification, Results from superimposition of poorly calcified bone in a disorganized fashion.PA radiographs may show narrowing of PDL with an ill-defined lamina dura, Involvement of the mandible leads to expansion of both buccal and lingual plates and Maxilla involvement leads to obliteration of the maxillary sinus?
• Involvement of two or more bones; can involve up to 75% of skeleton, If jaw is involved, facial asymmetry may result, Disease tends to stabilize and stop growing at skeletal maturity, May reduce surgically; up to 50% recur, Radiation therapy is contraindicated? What two syndromes are associated with this form of dysplasia and what makes them different?
- Monostotic Fibrous Dysplasia
- Polyostotic Fibrous Dysplasia:
• Jaffe-Lichtenstein syndrome:
o Polyostotic fibrous dysplasia
o Café au lait spots (coast of Maine)
• McCune-Albright Syndrome:
o Polyostotic fibrous dysplasia
o Café au lait spots (coast of Maine)
o Multiple endocrinopathies
- Sexual precocity, pituitary adenoma, and/or hyperthyroidism.
• Sexual precocity is the most common
o Menstrual bleeding, breast development, and pubic hair appear in females within first few years of life.
