Chapter 13 Study Questions Flashcards

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1
Q

A homeostatic system involves regulation of the , , or systems.

A

TEMPERATURE; WATER BALANCE; FOOD INTAKE

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2
Q

A modern classification of animals reflects the source from which they derive warmth. actively generate warmth internally in order to regulate their body temperature, whereas gain their heat from the environment. Animals in both classes actively regulate their temperature, but do so through metabolism, whereas do so behaviorally (such as by sitting on a hot rock).

A

endotherms; ectotherms; ENDOTHERMS; ECTOTHERMS

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3
Q

One advantage of endothermy is greater from environmental conditions. By producing a constant internal temperature, endothermy allows an animal to forage in a wider variety of environments. Also, in order to produce the chemical reactions necessary to produce heat, endothermy has allowed animals a capacity for utilization. Ectotherms are typically capable of only bursts of high-intensity activity.

A

INDEPENDENCE; GREATER; OXYGEN; short

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4
Q

The top level of control in a negative feedback control system is a comparator. In the case of body temperature regulation, this works like a : it contains a reference value, or “set ,” and it compares the present temperature of the body to the desired temperature. The system operates by means of feedback from the body—that is, when the desired temperature is reached, feedback information acts to shut the system off, and it remains off until the temperature deviates from the desired level. In mammals, this optimal level is usually in the range of °C.

A

THERMOSTAT; POINT; negative; “36 to 38”

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5
Q

Mammals can increase heat generation in response to a drop in body temperature in two ways, one involving a specialized type of tissue, and the other involving a specialized type of behavior. In the first case, the nervous system signals fat, which is full of , to metabolize molecules to produce heat. In the second case, the nervous system activates muscle fibers to cause heat-producing .

A

SYMPATHETIC; BROWN; MITOCHONDRIA; SHIVERS

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6
Q

Birds incubate eggs by keeping them in contact with a special, highly area of the skin known as the . A rat mother’s own thermoregulation compensates for the needs of her pups, which are born without and cannot regulate their own body temperatures until they are old enough to stray from the nest.

A

VASCULARIZED; brood patch; fur

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7
Q

Early experiments with local heating and cooling (via implanted wires) implicated a particular brain structure, the , in the control of temperature. Subsequent work demonstrated that neurons located in subregions of this structure, namely the area and the , change their rate of firing depending on body temperature, suggesting that this is the location of the “thermostat.”

A

hypothalamus; PREOPTIC; ANTERIOR HYPOTHALAMUS

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8
Q

Recent lesion experiments have suggested that in mammals, different brain sites are responsible for two main kinds of thermoregulation. thermoregulation (e.g., locomotion) is abolished by lesions of the , whereas (e.g., autonomic) thermoregulation is abolished by lesions of the

A

BEHAVIORAL; LATERAL HYPOTHALAMUS; PHYSIOLOGICAL; PREOPTIC AREA

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9
Q

Some basic cellular processes common to all animals evolved first in marine organisms and have persisted in that form up to the present day. These include expression and . A more watertight body has not evolved because we need to surrender water on occasion for purposes of elimination. We also use up and must actively replenish water and

A

GENE; METABOLISM; WASTE; SALT

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10
Q

The two main fluid compartments of the body are the intracellular compartment and the compartment. Fluid of the intracellular compartment is located (not surprisingly) within . Fluid of the compartment is located in two places: the fluid (the fluid that surrounds and bathes the cells of the body) and the blood .

A

extracellular; CELLS; extracellular; interstitial; plasma

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11
Q
  1. Semipermeable membrane—
  2. Physiological saline—
  3. Water—
  4. Concentration gradient—
  5. Salt—
  6. Saltier than body fluid—
  7. Passive movement of molecules from one location to another—
  8. Less salty than body fluid—
A
  1. cell membrane
  2. ISOTONIC
  3. solvent
  4. OSMOTIC PRESSURE
  5. solute
  6. hypertonic
  7. OSMOSIS
  8. hypotonic
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12
Q

A cell that comes into contact with a hypotonic solution has a higher concentration of molecules on its inside and a higher concentration of molecules on the outside. Because the cell membrane is , but not ions move into the cell faster than they leave, causing the cell to swell and eventually rupture

A

Na+; water; SEMIPERMEABLE; water; NA+

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13
Q

The extracellular fluid acts as a in the sense that it both provides and water, allowing the cell to maintain the correct internal concentration for the operation of cellular mechanisms.

A

RESERVOIR; accepts

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14
Q

Hypovolemic thirst can be triggered by , vomiting, or diarrhea. The word “hypovolemic” is a clue to the property of the external fluid that is monitored by the brain in this kind of thirst, namely blood . Since both solvent and are lost, the overall concentration of the fluid does not change.

A

HEMORRHAGE; VOLUME; solute; EXTRACELLULAR

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15
Q

Hypovolemia is detected by located in the heart and major blood vessels, and the brain responds by triggering both thirst and hunger. This extra is required to prevent the extracellular fluid from becoming .

A

BARORECEPTORS; salt; salt; HYPOTONIC

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16
Q

In addition to triggering the behavioral reactions to hypovolemia, the nervous system also mediates two physiological responses, one of which is vascular and one of which is hormonal. The nervous system mediates a constriction of the walls of blood vessels, which raises blood to compensate for the lost volume. The brain also mediates the release of the hormone , which further causes vessels to constrict and also instructs the to reduce the release of water into the urine.

A

SYMPATHETIC; pressure; VASOPRESSIN; KIDNEYS

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17
Q

Angiotensin II affects brain function by triggering the release of and also directly causes blood vessels to . It enters the brain via the “leaky” portion of the blood–brain barrier, where it binds to receptors within the and the organs and leads to pronounced thirst.

A

vasopressin; constrict; CIRCUMVENTRICULAR; SUBFORNICAL

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18
Q

Some causes of thirst include sweating, urination, respiration, and eating salty food. In osmotic thirst, the of the extracellular fluid is increased—that is, the concentration of in the extracellular fluid increases and water starts to move cells.

A

osmotic; OSMOLALITY; SALT; OUT OF

19
Q

The observation that an injection of saline directly into the hypothalamus causes animals to start drinking led to the search for in the brain. Cells that may function in this way are located in the area, the anterior , the nucleus, and the organum of the (a circumventricular organ, OVLT for short).

A

HYPERTONIC; osmosensory neurons; PREOPTIC; hypothalamus; SUPRAOPTIC; VASCULOSUM; LAMINA TERMINALIS

20
Q

In an experiment on the cues for drinking, animals were allowed to drink freely and the ingested water allowed to reach the stomach. When they were made thirsty and then allowed to drink, these animals , indicating that simply wetting the mouth and throat sufficient to cause animals to stop drinking. We stop drinking water enters the extracellular space. This implies that we stop drinking due to .

A

WAS NOT; drank continuously; is not; BEFORE; signals prior to body-water replacement

21
Q

The hormone conserves Na+ by acting on the .

A

ALDOSTERONE; KIDNEYS

22
Q

The regulation of food intake is considerably more complicated than the regulation of fluid balance. This is probably the case because our food must provide us not only with energy but also with , which are defined as that are not used as sources of but are required for the effective functioning of the body, such as growth and .

A

NUTRIENTS; CHEMICALS; energy; MAINTENANCE

23
Q

Basal metabolism can be calculated using a mathematical expression: kcal/day = × weight0.75. This is known as the equation. The equation does not hold true during food . Under these circumstances, basal metabolism . This phenomenon raises difficulties for people who are following a(n) to try to lose weight. On the plus side, food is the only known way that animals can be made to live .

A

“70”; KLEIBER; KLEIBER; DEPRIVATION; decreases; diet; DEPRIVATION; longer

24
Q

The most important sugar used by the body is glucose, which is classified as a carbohydrate. Although most of the body can also derive energy from more molecules, such as , which are produced when is metabolized, the is heavily dependent on glucose for its functioning. In order to maintain reserves of glucose, it is stored by the in a more complex form, called , which can be converted back into glucose when needed.

A

simple; complex; KETONES; FAT; brain; LIVER; GLYCOGEN

25
Q

The process of shuttling glucose in and out of storage is controlled by two hormones of the : insulin, which promotes the conversion of glucose to glycogen, and , which promotes the breakdown of glycogen to glucose.

A

pancreas; GLUCAGON

26
Q

Long-term energy storage is accomplished by depositing fat into tissue. Fat may either be eaten or made in the body from plus other nutrients. Fat may be broken down into acids to supply energy to most of the body, or into for use by the brain.

A

adipose; GLUCOSE; fatty; GLUCOSE

27
Q

Glucose gets into cells via glucose that span the cell membrane; these molecules require in order to function, except in the .

A

TRANSPORTERS; INSULIN; brain

28
Q

The three phases of eating that sequentially stimulate insulin release are:

  1. The phase—the stimulates the pancreas to secrete insulin.
  2. The phase—the presence of food in the tract stimulates the release of gut hormones, which stimulate the pancreas to secrete insulin.
  3. The phase—glucose levels of the blood increase as food is absorbed, and this increase is detected by in the liver, which signal the brainstem via the nerve. The brainstem then signals the pancreas to secrete insulin.
A
  1. CEPHALIC; brain
  2. DIGESTIVE; digestive
  3. ABSORPTIVE; GLUCODETECTORS; VAGUS
29
Q

A lack of insulin causes the disease . In the form of the disease, the pancreas stops producing insulin. Due to this lack, only the can make use of , and the rest of the body must rely on . Glucose also cannot be stored in the absence of insulin, so some of it is passed in the . diabetes is due to decreased production of or to insulin and is treated by reducing glucose intake.

A

diabetes mellitus; Type 1; BRAIN; glucose; FATTY ACIDS; URINE; Type 2; SENSITIVITY

30
Q

Animals whose insulin levels have been lowered become and eat meals. Moderate levels of insulin result in the consumption of meals. These two results support the idea that insulin levels signal to the brain. Rats treated with large doses of insulin eat meals; presumably all of their glucose is , the brain has detected this situation, and the animal feels .

A

hungry; large; normal; SATIETY; LARGE; stored; HUNGRY

31
Q

Initial discoveries led to the - theory of eating, which proposed that two brain centers, acting in opposition, control the intake of food. According to this theory, the stimulates feeding behavior, while the inhibits feeding behavior. In humans, fMRI has revealed that glucose intake after fasting affects the activity of the .

A

DUAL-CENTER; LATERAL HYPOTHALAMUS; VENTROMEDIAL HYPOTHALAMUS; hypothalamus

32
Q

Animals with lesions of the VMH eat voraciously and soon become obese. Careful observation of these animals soon revealed some challenges to the idea of the VMH as a satiety center. Immediately after the VMH lesions are made, such animals exhibit (ravenous eating), in which the rate of consumption is two to three times greater than normal. Eventually, these animals stabilize at a new, higher body weight. At this point, VMH-lesioned animals show levels of satiety after eating, making it unlikely that the VMH is the sole determinant of satiety.

A

BILATERAL; HYPERPHAGIA; NORMAL

33
Q

Early animal studies indicated that bilateral lesions of the LH result in a refusal to eat called . Once the animals resume eating they eventually stabilize their body weight, although at a set point, which is “defended” from then on. If the animal is forced to gain weight, it will return to the new target weight when allowed to feed normally. These data imply that LH-lesioned animals get and will eat, so the LH cannot be the hunger center in the brain.

A

APHAGIA; LOWER; hungry; sole

34
Q

Peripheral signals for appetite control come from four peptides. Fat cells secrete ; the pancreas secretes ; the stomach secretes ; and the intestines secrete . The nucleus of the hypothalamus contains a highly specialized appetite controller governed by these four peptides.

A

LEPTIN; INSULIN; GHRELIN; “PYY3-36”; ARCUATE

35
Q

Ob/ob mice are defective in the production of leptin, which is normally produced by cells and is released . Leptin receptors are found in a variety of brain locations, including plexus, cortex, and , especially the LH, supraoptic, arcuate, and paraventricular nuclei.

A

FAT; into the blood; CHOROID; HYPOTHALAMUS

36
Q

is a powerful appetite stimulant that fluctuates in circulation, with levels during fasting and immediately following a meal. is a powerful appetite suppressant that fluctuates in circulation, with levels during fasting and immediately following a meal.

A

GHRELIN; rising; falling; “PYY3-36”; remaining relatively low; rising

37
Q

On reaching the nucleus of the hypothalamus, leptin suppresses the production of peptide neurotransmitters known to induce eating, such as Y (NPY) and -related peptide (AgRP), while enhancing the activity of (POMC) and - and -regulated transcript (CART), known to inhibit eating. The POMC and CART neurons project to the hypothalamus where they cause the release of alpha- stimulating hormone . NPY and AgRP neurons project to the nucleus of the hypothalamus, where signals an increase in hunger. This is also where acts as an antagonist and α-MSH acts as an agonist at the receptors (MCR).

A

ARCUATE; NEUROPEPTIDE; AGOUTI; PRO-OPIOMELANOCORTIN; COCAINE; AMPHETAMINE; LATERAL; ALPHA-MSH; PARAVENTRICULAR; NPY; “AgRP”’ MELANOCORTIN

38
Q

Many systems participate as appetite and satiety signals. Appetite signals from the hypothalamus converge on the (NST) in the brainstem, where appetite signals are integrated. The gut releases after eating, which inhibits eating. , such as anandamide, stimulate hunger both by affecting the hypothalamus and activating the mesolimbic dopamine system.

A

NUCLEUS OF THE SOLITARY TRACT; GHOLEXYSTOKININ; ENDOCANNABINOIDS; REWARD

39
Q

After surgical fat removal, golden-mantled ground squirrels will food intake to the fat. The implication of this is that liposuction as a treatment for obesity in humans is to be successful over the long haul.

A

increase; replace; unlikely

40
Q

Five different strategies are used to combat the current obesity epidemic in the United States. Drugs that modify the functioning of the hypothalamic appetite system may help in controlling . Drugs that lead to increased may cause the body to expend extra calories in the form of heat. Drugs that inhibit the formation of blood vessels, or may interfere with the formation of fat tissue. One obesity medication that is currently approved reduces or interferes with the digestion of fat. Strategies that lead to a reduction in the properties of food may prove beneficial for weight loss. Finally, some people resort to surgery to part of the stomach or intestines, which leads to a decreased volume and absorptive capacity and possibly a decrease in the release of that stimulates hunger.

A

appetite; METABOLISM; ANGIOGENESIS; ABSORPTION; REWARDING; BYPASS; GHRELIN

41
Q

In anorexia , eating is drastically curtailed and sometimes combined with purging through vomiting and the use of laxatives, resulting in pathological thinness and sometimes organ damage and eventual death. The disorder is much more prevalent in adolescent and adult than in . People with anorexia think about food and react to its presence normal subjects. It is common for people with anorexia to have a distorted image of their bodies, viewing themselves as . Similar distortions occur in bulimia, a hallmark of which is a cycle of binge eating and .

A

nervosa; females; males; a great deal; more than; fat; PURGING

42
Q

Explanations of anorexia nervosa often emphasize a mismatch between the individual’s internal target weight and what approves of. However, anorexia is known to have occurred even in times when a plumper body style was considered the height of beauty.

A

SOCIETY; plumper

43
Q

Within our digestive systems, exist that assist with digestion. These normal or gut are different among individuals. These distinct combinations are called and are related to an individuals diet.

A

BACTERIA; FLORA; ENTEROTYPES

44
Q

Changes in our gut microbiota can occur with disease and treatment for infections with . Recently, has been used to restore healthy microbiota.

A

antibiotics; FECAL TRANSPLANTATION