Chapter 13: Disorders of the Spleen Flashcards
1
Q
What are the 4 functions that impact disease states in the spleen?
A
- phagocytosis of blood cells and particulate matter
- Antibody production
- hematopoiesis
- sequestration of formed blood elements
2
Q
What is the one major clinical manifestation of splenic insufficiency?
A
An increased susceptibility to sepsis caused by encapsuated bacteria such as pneumococci, meningococci, and H influenza
3
Q
Splenomegaly
A
dragging sensation in the left upper quadrant
4
Q
Nonspecific acute splenitis
A
spleen is enlarged and soft
-major feature is acute congestion of the red pulp
5
Q
Congestive splenomegaly
A
- chronic venous outflow obstruction
- cirrhosis of the liver can cause it
- pipe-stem hepatic fibrosis of schostosomiasis are cause a really severe congestive splenomegale
- organ is firm
- elevated portal venous pressure stimulates deposition of collagen in the basement membrane of the sinusoids
6
Q
Splenic infarcts
A
- occlusion of the major splenic artery or any of its branches
- wedge-shaped and subcapsular
7
Q
Neoplasms
A
-rare except in myeloid and lymphoid tumors
8
Q
Congenital abnormalities
A
Complete absence of spleen is rare…. hypoplasia is more common
-Accessory spleens are common… cause hematologic disorders
9
Q
Rupture
A
- blunt trauma
- infectious mononucleosis, malaria, typhpoid fever, and lymphoid neoplasms
