Chapter 11: Immunity Flashcards
Define the term phagocyte.
Specialised white blood cells that engulf and
destroy pathogens. There are two types:
neutrophils and macrophages.
State where phagocytes are produced.
Bone marrow
Define the term phagocytosis.
The process by which phagocytes engulf
and destroy pathogens.
Outline the process of phagocytosis.
- Phagocyte moves towards pathogen via chemotaxis
- Phagocyte engulfs pathogen via endocytosis to form a phagosome
- Phagosome fuses with lysosome forming a phagolysosome
- Lysozymes digest pathogen
- Products of pathogen hydrolysis absorbed by the phagocyte or
released into the cytoplasm
Define the term immune response.
The body’s response to ‘non-self’ antigens. It
consists of a non-specific phase involving
neutrophils and macrophages, and a specific
phase involving T and B lymphocytes.
What is an antigen?
A chemical present on the surface of a cell
that induces an immune response.
What are antigen presenting cells (APCs)?
Any type of immune cell which displays
parts of a pathogen (antigens) on its
surface to elicit an immune response.
What is meant by the term self-antigen?
Antigens present on an organism’s cells
that are tolerated by their own immune
system. They induce antibody formation
in other organisms.
What is meant by the term non-self antigen?
Foreign antigens that originate from
outside the body and induce an immune
response.
Describe the structure and function of T
lymphocytes.
● Mature in the thymus gland
● Many specific receptors and immunoglobulins on surface
● Four main types of T lymphocyte:
○ T helper - bind to antigens on antigen-presenting cells and secrete interleukins ○ T killer - secrete perforin, destroying pathogens with a specific antigen ○ T memory - provide immunological memory ○ T regulatory - suppress other immune cells to prevent autoimmune disease
Describe the structure and function of B
lymphocytes.
● Mature in the bone marrow
● Many specific receptors and immunoglobulins on surface
● Three main types of B lymphocyte:
○ Plasma cells - produces antibodies specific to a particular pathogen ○ B effector - divides to form plasma cells ○ B memory - provide immunological memory
Define the humoral immune response.
Immunity regulated specifically by the
production of antibodies. Associated with
B lymphocytes.
State the role of plasma cells.
Production of antibodies specific to a
particular pathogen.
Outline the process of the cell-mediated response.
Complementary T helper lymphocytes bind to foreign antigens on
antigen-presenting cell. T cells undergo clonal expansion.
Four main types of T lymphocytes produced:
● T effector cells
● T killer
● T helper cells
● T memory cells
Outline the process of the humoral response.
- Complementary T helper lymphocytes bind to foreign antigens on
antigen-presenting T cells - Cytokines released that stimulate the clonal expansion of
complementary B lymphocytes - B lymphocytes differentiate into plasma cells
- Plasma cells secrete antibodies with complementary variable region
to antigen. Antibodies destroy the pathogen