chapter 10: neurodevelopmental & neurocognitive Flashcards
what is the difference between neurodevelopmental and neurocognitive
neurodevelopmental occurs during childhood and neurocognitive is later in life
ADHD
persistent issues with attention and impulsivity
- combined presentation: 6+ inattention and 6+ hyperactivity/impulsivity
- predominantly inattentive: 6+ inattentive and less than 6 of other
- predominately hyperactive/impulsive: 6+ impulsive and less of other
3.4-6% school aged across the world
- symptoms must be present before age 12 and seen in multiple settings
- boys more diagnosed, but girls show more inattentive features so less diagnosed
typical symptoms seen for ADHD
- poor school performance: inability to focus can hinder ability to learn information and perform below their capabilities
- can cause poor social relationships can be intrusive, irritable, and demanding and can show mood and temper problems
- common to have comorbid learning disorders: reading, written expression, developmental coordination disorder (20-25% have in addition to ADHD a specific learning disorder)
- behavioral problems can become severe enough to cause a conduct disorder diagnosis (usually seen in combined ADHD diagnosis) acting uncaring and antisocial
- 45-60% of children with ADHD will develop conduct disorder, abuse drugs, alcohol, and/or violate the law
long-term outcomes for children with ADHD
impairing symptoms into adulthood can persist in 50-78% of cases
increased risk for: antisocial, substance abuse, mood & anxiety disorders, marital problems, traffic accidents, legal infractions, frequent job changes
- 4.4% of adults could be diagnosed with ADHD (most likely male)
- 2X risk of premature death from unnatural causes
biological factors for ADHD
-prefrontal cortex: control of cognition, motivation, behavior
-striatum: working memory and planning
- cerebellum: motor behaviors
- cerebral cortex: less connectivity between frontal areas that influence emotional reactions, attention
thought that ADHD children are develop cognitively slower than normal children so its hard to maintain attention and behavioral control at age-appropriate level
- catecholamine neurotransmitters: dopamine & norepinephrine
psychological and social factors
families that experience frequent disruptions and parents prone to aggressive and hostile behavior, substance abuse ( could be shared genetic component)
-family interaction patterns especially during early childhood has big influence on severity of ADHD
treatment for ADHD bio
usually stimulant drug (ritalin, dexedrine, and adderall) and 70-85% respond with decrease in demanding, disruptive, and noncompliant behavior
- may increase levels of dopamine in synapse, enhance release, and inhibit reuptake
- drugs that impact norepinephrine levels (guanfacine) help reduce tics and increase cognitive performance but have side effects (constipation, dizziness, dry mouth, etc)
therapy for ADHD
reinforcing attentive, goal-directed and prosocial behaviors and extinguishing impulsive and hyperactive behaviors
- behavioral therapy highly effective
autism spectrum disorder
- deficit in social interactions and communications
- usually beginning of life will see not smiling, or cooing as a baby.
- they usually do not cuddle and will not make eye contact, delayed language development - restricted, repetitive patterns of behavior, interests, and activities
typical symptoms seen in Autism spectrum disorder
- 25-30% of school aged children do not develop useful speech or do not use speech as expected for age
- instead of engaging in play with toys they become preoccupied with one feature
- routines and rituals are extremely important
- usually symptoms are seen early childhood by age 2 (most predictive is language development and IQ before 6)
what is echolalia
in autism instead of generating words individuals just repeat what they hear and will reverse pronouns saying you instead of I
contributors to autism spectrum disorder
- definite genetic component - higher rate of other genetic disorders associated with cognitive impairment (fragile X, PKU)
- several gene abnormalities not just one associated with autism
- seizure disorder
- greater head and brain size
- abnormalities in cerebellum, cerebrum, amygdala, and possibly hippocampus
prenatal environment and ASD
- possible maternal gut microbiome imbalance could be associated with abnormalities in brain function and behavior in offspring
-MIA (maternal inflammatory response) response due to stress, infection, asthma, allergies, etc acts like disease primer to fetus and makes them vulnerable to more “hits” - too many cytokines
treatment for autism spectrum disorder
- selective serotonin reuptake: reduce repetitive behavior and aggression
- atypical antipsychotic medications: more reliable to reduce obsessive and repetitive behaviors, improve self-control
-stimulants: improve attention
Therapy:
- operant conditioning: reduce repetitive/ritualistic behaviors tantrums, and aggression and deficits or delays in communication and interactions
- behavioral: reinforce socially acceptable behaviors and decrease/eliminate undesirable ones
intellectual disorder
significant deficits in intellectual abilities and life functioning: abstract thinking, reasoning, learning, problem solving, planning
deficits in three domains (conceptual, social, practical)
1-3% of population has
levels of severity of ID
mild: some limitations in typical academic and job skills but can hold a job
moderate: can be physically clumsy and usually dont achieve beyond 2nd grade academic skills, but with special education could. need training for personal needs
severe: require support in all aspects of daily living, they can feed themselves with spoon and dress but have to be simple clothing
profound: co-occuring sensory and motor impairments and limit participation to usually just watching, require assistance with everything
what do intelligence tests measure
verbal comprehension, working memory, perceptual reasoning, quantitative reasoning, abstract thought, processing speed
intellectual developmental disorder (biological)
chromosomal, gestational disorders, exposure to toxins, brain injury, metabolism and nutritional problems seizure disorders
genetic factors in ID
- 300 genes associated with
- PKU cant metabolize phenylalanine and builds up to cause brain damage 1:20,000 births
- tay-sachs child around 3-6 months will experience degeneration of nervous system and will pass by age 6
- down syndrome (triple 21 chromosome)
- fragile X (tip of X chromosome - usually seen more in males)
- fetal alcohol syndrome
fetal alcohol syndrome
2-15 children per 10,000
- 10% of women around the world drink during pregnancy and 1:67 will deliver baby with alcohol syndrome highest in European region
other ways during early childhood ID can occur
- shaken baby syndrome ( bleeding in brain or behind eyes as a result can lead to seizures, partial/total blindness, paralysis, ID, and death)
- toxins: lead, arsenic, mercury
- accidents that lead to brain trauma -> ID
sociocultural factors of ID
- more likely from lower SES background
- poor mothers are less likely to receive good quality prenatal care, etc. lower income schools have less favorable teaching environments
treatments for ID: drugs
- meds to reduce seizures which are common
- neuroleptic meds: reduce aggressive, destructive, antisocial behavior
- atypical antipsychotics to help aggression and self-injury
- antidepressants
behavioral treatment: ID
enhance positive behavior and reduce negative ones
- work in steps towards one large major goal
- parent training
social programs for ID
- the early intervention the better outcome, may start days after birth to reduce social conditions (abuse, malnutrition, exposure to toxins, etc) that could have an adverse effect on children’s development
ex: infant health and development program for those under 5.5 lbs or born before 37 weeks. health provider visit house within 3 years to enhance development
-mainstreaming:opportunities for inclusion for student with ID and special needs are combined into traditional classrooms with peers
- group homes: provide assitance with daily tasks can help with social and vocational skills
specific learning disorder
deficit in 1 or more academic skills: reading, written expression, mathematics. for diagnosis their performance has to be significantly lower than what is expected for age, schooling/ overall intelligence
- 40% never finish high school because they have to work extremely hard to sometimes still fail