chapter 10- hemoglobin and myoglobin Flashcards
(134 cards)
is the heme group conjugated or un-conjugated?
conjugated
hemoglobin contains how many heme groups?
four; one on each of the sub units
myoglobin contains how many heme groups?
One
molecular oxygen binds how to the Fe(II) atom in heme?
irreversibly
Heme is composed of an organic _____ and a ____ atom
an organic protoporphyrin and a metal atom
How many oxygen molecules does myglobin bind to reversibly?
One
How many oxygen molecules does hemoglobin bind to reversibly
four
hemoglobin is used to transport oxygen over _____ distances such as from the ______ to the _______
large distances such as from the lungs to all tissues
Myoglobin is used to transport oxygen over_____ distances such as ______ and behaves as _______
over short distances such as in the muscles and behaves as local “storage” reservoir of oxygen.
heme is what type of group
prosthetic group which contains a central iron atom
Each iron atom can form ____ coordination bonds
six coordination bonds
How many of iron’s bonds are with oxygen?
one of six of iron’s bonds are with oxygen
A heme group contains 4_____ that are liked via _____
pyrrole rings linked via methene (methine) bridges.
The T state of hemoglobin has _____ affinity for oxygen than R state because ______
T state has lower oxygen affinity than R state because the Fe-Nporphyrin bonds are longer
The fifth bond of iron in the heme group forms with ______
an imidazole ring of a histidine
The prosthetic group of hemoglobin and myoglobin is ______
heme
The organic ring component of heme is _____
porphyrin
Under normal conditions the central atom of heme is
Fe2+
How many bonds does the iron of heme have to the nitrogen in the porphyrin?
four
The iron of heme has _____ bonds. What are these bonds to?
4 to nitrogen in porphyrin
1 to oxygen
1 to imidazole ring of histidine
In deoxyhemoglobin the central atom is what?
displaced 4 A out of the plane of the porpyhrin ring system.
Does hemoglobin of myoglobin have a higher oxygen affinity?
Myoglobin
Which molecule (hemoglobin or myoglobin) delivers oxygen more efficiently to tissues?
hemoglobin
The binding pattern of hemoglobin is considered (cooperative or uncooperative)
cooperative