Chapter 10 - Blood and Hemopoiesis

Question 1

Which of the following proteins associated with the erythrocyte plasma membrane is responsible for maintaining the cell's biconcave
disk shape?
(A) HbA1
(B) HbA2
(C) Porphyrin
(D) Spectrin
(E) a-Actinin

Answer 1

D. Spectrin is associated with the erythrocyte cell membrane and assists in maintaining its biconcave disk shape (see Chapter 10 II B).

Question 2

Which of the following is an immunocompetent cell?
(A) Red blood cell
(B) Lymphocyte
(C) Platelet
(D) Neutrophil
(E) Basophil

Answer 2

B. Lymphocytes are immunocompetent cells (see Chapter 10 VI G).

Question 3

Which of the following is derived from CPU-Meg (MKP cells)?
(A) Red blood cell
(B) Lymphocyte
(C) Platelet
(D) Neutrophil
(E) Basophil

Answer 3

C. Platelets are derived from CFU-Meg (MKP cells) (see Chapter 10VI F).

Question 4

Which of the following is derived from CFU-E?
(A) Red blood cell
(B) Lymphocyte
(C) Platelet
(D) Neutrophil
(E) Basophil

Answer 4

A. Red blood cells are derived from CFU-E (see Chapter 10 VI C).

Question 5

Which of the following is derived from CFU-GM?
(A) Red blood cell
(B) Lymphocyte
(C) Platelet
(D) Neutrophil
(E) Basophil

Answer 5

D. Neutrophils are derived from CFU-GM (see Chapter 10 VI D).

Question 6

Which of the following is associated with
demarcation channels?
(A) Red blood cell
(B) Lymphocyte
(C) Platelet
(D) Neutrophil
(E) Basophil

Answer 6

C. Platelets are derived from megakaryocytes, and those cells possess demarcation channels
(see Chapter 10 VI F).

Question 7

Which of the following is derived from
myeloblasts?
(A) Red blood cell
(B) Lymphocyte
(C) Platelet
(D) Monocyte
(E) Basophil

Answer 7

E. Basophils are derived from myeloblasts (see Chapter 10 VI D).

Question 8

Which one ofthe following cells is associated with antibody production?
(A) Red blood cell
(B) Lymphocyte
(C) Monocyte
(D) Neutrophil
(E) Basophil

Answer 8

C. Lymphocytes and plasma cells manufacture antibodies (see Chapter 10 VI G).

Question 9

Which of the following possesses specific and azurophilic granules?
(A) Red blood cell
(B) Lymphocyte
(C) Platelet 
(D) Neutrophil 
(E) Monocyte

Answer 9

D. Neutrophils possess both azurophilic and specific granules (see Chapter 10 II B 2).

Question 10

Which of the following is derived from reticulocytes?
(A) Red blood cell
(B) Lymphocyte
(C) Platelet
(D) Neutrophil
(E) Basophil

Answer 10

A. Red blood cells are derived from reticulocytes (see Table 10.5).

Question 11

A 4-year-old boy is taken by his parents to the pediatrician because of vomiting, head­aches, and tenderness in the bones of his arms and legs. On palpation, the physician notes that many lymph nodes are enlarged, as is the liver. The pediatrician should order a complete blood count in order to determine whether or not the child may have:
(A) chronic leukemia.
(B) infectious mononucleosis.
(C) von Willebrand disease.
(D) acute leukemia.
(E) pernicious anemia.

Answer 11

D. Acute leukemia is a disease of children with symptoms that include headaches; vomiting; swollen lymph nodes, liver, and spleen; and the sensation of tenderness in bones. Chronic leu­kemia is a disease that usually affects adults. von Willebrand disease is a coagulation disorder and does not have the same symptoms as acute leukemia. Infectious mononucleosis affects mostly young adults of high school and college age. Pernicious anemia is caused by vitamin B deficiency, and its symptoms do not resemble those of acute leukemia (see Chapter 10 II B 2 Clinical Considerations).