Chapter 1: Structure and Function Flashcards

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1
Q

What is the difference between the function of a neuron and the function of a glial cell?

A

Neurons underlie all our behaviour, they work in circuits to receive, integrate, and distribute information across billions of cells.

Glial cells are all non-neuronal cells in the brain. They function to provide structural, nutritional, and other support to the brian

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2
Q

What is the Neuron Doctrine?

A

Neurons and other brain cells are structurally, metabolically, and functionally independent.

Information is transmitted from neuron to neuron across tiny gaps called synapses.

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3
Q

What are the four functional zones of a neuron?

A
  1. Input zone: recieves information from other neuorns and specialized sensory structures. This area is made up of the dentrites.
  2. Integration Zone: initiates neural electrical activity. It integrates information and determines whether or not to send a signal of its own. It is made up of the Soma.
  3. Conduction Zone: where the action potential is propagated. Made up of axons
  4. Output Zone: sends information to other neurons, made up of axon terminals.
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4
Q

What are three types of neurons and their characteristics?

A

Motor Neurons: they transmit messages to the muscles and glands. They have long axons.

Sensory Neurons: they are neurons that are affected by changes in the environment. they vary in shape and size depending on its sense specialization.

Inter-neurons: Neurons that receive input and send output to other neurons. this is the most common type of neuron. They have small axons.

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5
Q

What are three neuron shape classifications?

A

Multi-Polar: Have many dendrites and a single axon; the most common type

Bi-Polar: have a single dendrite and single axon; is most common in the sensory system.

Uni-polar: has a single branch that leaves the cell body and extends in two directions. One ends in the input zone, the other ends in the output zone. They transmit touch information from the body to the spinal cord.

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6
Q

What are the 3 components of the synapse?

A

The specialized membrane on the presynaptic axon terminal. This are transmits information by releasing neurotransmitters.

The synaptic clef: the space between the pre and post synaptic neurons. It is ~20-40nm

the specialized postsynaptic membrane which receives information y responding to the neurotransmitters from the presynaptic neuron.

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7
Q

What is the phenomenon of neuroplasticity?

A

The phenomenon where new patterns of synaptic activity and new neural circuits form in response to changes in experience and the environment. It involves synapses coming and going, dendrites changing shape, and dendritic spines waxing and waning.

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8
Q

What is the job of the axon hillock?

A

To integrate information from coming synapses and determine if when the neuron is to produce its own signal.

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9
Q

What is axon transport?

A

This is when substances like enzymes and proteins move up and down the hollow tube like axon. Anterograde transport is the movement from the cell body to the axon terminals. Retrograde transport is movement from the axon terminals to the cell body.

Axon transport is far slower than the movement of electrical impulses and action potentials down the axon membrane

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10
Q

What are the 4 main types of Glial cells?

A

Oligodendrocytes: these en-sheath the axons with myelin in the Central nervous system. They can provide myelin to multiple axons at once

Schwann Cells: These en-sheath the axons with myelin in the peripheral nervous system. they can provide myelin to only one axon at a time.

Astrocytes: star shaped cells that weave between neurons with tentacle like extensions. They perform functions like increasing blood flow, forming tough protective membranes, and secreting chemical signals that affect synaptic transformation and formation.

Microglial: small, mobile cells that remove cellular debris from injured or dead cells.

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11
Q

What are the two divisions of the peripheral nervous system?

A

The somatic nervous system: made up of nerves that interconnect the brain, major muscles, and sensory systems of the body

Autonomic Nervous system: nerves that connect to the viscera (internal organs)

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12
Q

What are cranial nerves (provide examples)?

A

Are one of two types of nerves in the somatic nervous system. These nerves connect directly with the brain. There are 12 pairs:

  • Olfactory Nerves
  • optic nerves
  • oculomotor
  • trochlear
  • trigeminal
  • abdcens
  • facial
  • Vestibulocochlear
  • glossophraygeal
  • vagus
  • spinal accessory
  • hypoglossal
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13
Q

What are spinal nerves? What are the different types?

A

They are one of two types of nerves in the somatic nervous system. There are 32 pairs. Each nere has motor fibres in the ventral (front) part o the spine and sensory fibres in the dorsal (back) part of the spine.

There are:
8 cervical nerves (neck)
12 thoratic nerves (torso)
5 lumbar nerves (lower back)
5 socral nerves (pelvic)
1 coccygeal nerve (bottom)
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14
Q

What are the characteristics of the divisions of the autonomic nervous system?

A

The Sympathetic Nervous system: acts as fight or flight, prepares the body for action. The neurons of the sympathetic nervous system travel from the spinal cord to the sympathetic ganglia which then innervates the major organ systems

The parasympathetic Nervous System: prepares the body to relax, the rest and digest system. The neurons of the parasympathetic nervous system travel from the central nervous system to the parasympathetic ganglia which then innervates the major organ systems.

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15
Q

What are the 3 different planes for dividing the brain?

A

Sagital –> divides the brain into left and right
Coronal –> divides the brain into front and back
Horizontal –> divides the brain into upper and lower

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16
Q
Define the following neurological location terminology:
Medial
lateral
ipsilateral
contralateral
superior
inferior
basal
anterior
posterior
distal
proximal
afferant
efferent
dorsal 
ventral
A

Medial: towards the middle
lateral: towards the side
ipsilateral: on the same side
contralateral: on the opposite side
superior: above
inferior: below
Basal: towards the bottom
Anterior: locations towards the front of the brain
Posterior: locations towards the back of the brain
distal: towards the end, far
proximal: towards the centre, near
Afferent: pathways that carry action potentials towards the brain
Efferent: pathways that carry action potentials away from the brain
Dorsal: towards the back
Ventral: towards the front.

17
Q

What is the difference between grey matter and white matter?

A

Grey matter is tissue made predominantly of dentrites and cell bodies. It is mostly found in the cortex and receives information.
White matter is tissue made mostly of axons sheathed in myelin. It mostly transmits information

18
Q

What is structure of the outer layer of the brain?

A

It is called the cerebral cortex and it is lumpy and convoluted.
the ridges are called gyri (single gyrus) and the crevices are called sulci (single sulcus), these divide the brain into lobes

The convolution creates greater surface area.

The cortex is made up of 6 distinct layers of cells:

  • Layer 1: has few cell bodies
  • layer 3 has pyramidal cells
  • layer 5 has many neurons with large cell bodies and pyramidal cells
  • layer six has large bodied neurons
19
Q

What are the four lobes of the brain and their locations? how are they divided?

A

The frontal lobe: top down processing, establishes gaze in accordance with cognitive goals.

The parietal lobe: sits between the frontal and occipital lobe
Temporal lobe: on the underside of the brain
Occipital lobe: posterior of the brain.

The sylvian fissure (lateral sulcus) divides the temporal lobe from other regions.
The central sulcus divides the frontal and parietal lobes.

20
Q
What are the major functions of the following parts of the brain:
Cerebral Cortex
Corpus Collosum
Post-central gyrus
precentral gyrus
A

Cerebral Cortex: responsible for may complex cognitive functions like: body movement and sensation, speech, memory, visual systems, personality etc.

Corpus Collosum: connects the hemispheres through millions of axons. Allows the hemispheres to communicate.
Post-central gyrus: mediates sense of touch. Is located in the parietal lobe just behind the central sulcus.
Pre-central gyrus: important for motor control. Is located in the frontal lobe, just in front of the central sulcus.

21
Q

What are the parts of the brain stem and their functions?

A

The cerebellum: involved in the regulation of movement and some learning
The pons: connects the midbrain and the medulla, contians nerve fibre important for motor control and is the point of origin for some cranial nerves
The medulla: transitions the brain into the spinal cord, point of origin for some cranial nerves, involved in heart beat and blinking

22
Q

What does it mean to say we are bilaterally symmetrical?

A

like all vertebrates, our bodies are mirror images left to right and in the brain, each side of the body is controlled by the contralateral hemisphere of the brain.

23
Q

What is the Basal Ganglia:

A

It is forebrain nuclei (clusters of neurons) that include the caudate nucleus, putmen, and the globus pallidus. It is important for controlled movement.

24
Q

What is the limbic system and its 7 major structures?

A

An important network of nuclei that regulate emotions and learning. It is made up of the:

  • Amygdala: emotional regulation
  • Hippocampus: spatial cognition, learning, and memory
  • Fornix: a fiber track that runs from the hippocampus to the mammillary body, implied in learning
  • Cingulate gyrus: a strip of cortex from the frontal and parietal midline, implicated in many cognitive functions
  • olfactory bulb: terminates in the nasal passage, uses small openings in the skull to provide receptors for smell.
  • Thalamus: traffic control for sensory information
  • Hypothalamus: controls the pituitary gland, and vital functions like hunger, thirst, temperature regulation etc.
25
Q

Describe the function of the following midbrain structures:

  • Tectum (Superior and inferior collculi)
  • Tegmentum (substantia nigra, periaqueductal grey, reticular formation)
A

Tectum: has specific sensory roles. Made up of the superior collculi which work in visual processing and inferior collculi which work in audio processing.

Tegmentum: is the main body of the midbrain and is made up of:

  • The substantia Nigra: a source for dopaminergic projections
  • The periaqueductal grey: pain perception
  • reticular formation: important for sleep and arousal
26
Q

How is the soft structure of the brain protected?

A

It floats in three layers of membranes called the meninges:

  • -> dura-mater is the outerlayer and is very tough
  • -> pia -mater is the inner later and is very delicate
  • -> arachnoid: is the thin middle layer. It is weblike and creates a resevoir (subarachnoid space) which suspends the brain in cerebrospinal fluid.
27
Q

What is meningitis? What about Meningiomas?

A

Meningitis is an infection of the meninges. Dangerous because any swelling puts pressure on the delicate brain.
Meningiomas: are tumours in the meninges

28
Q

What two fluids are vital to the brain and why?

A

Cerebrospinal fluid: conveys nutrients and signalling chemicals to the brain, collects waste. The ventrical system in the brain is made up of ventricles filled with cerebrospinal fluid.

Blood: the brain consumes 20% of the bodies energy provided by blood. Blood aroives vi the cartoid and vertebral arteries . These arteries combine into the basilar artery which branches into 3 cerebral arteries which then branch into fine vains and capillaries. The blood brain barrier protects the brain from harmful substances (like infection) in the blood by preventing the blood from direct access to the brain.)

29
Q

What is a CAT scan and it’s pros and cons

A

Brain image. Uses x-ray to measure amount of radiation absorbed at each point to generate a picture of the brain.
Has medium resolution and is good for seeing strokes, tumours, and physiological changes in the brain but doesn’t have much detail

30
Q

What is an MRI and fMRI, including pros and cons?

A

The MRI is higher resolution than the CAT scan and can provide more detail of brain structure. It is still computer generated and is still just a picture

the fMRI: is a way of charting brain activity. Still computer generated which provides room for bias in its imaging. Doesn’t have good temporal resolution

31
Q

What is the PET scan and its pros and cons

A

PET scan depicts brain activity through tracing radioactive chemicals. it is very sensitive to quick changes in the brain and is not computer generated. Has good temporal resolution but not as good spatial resolution

32
Q

What is Transcranial magnetic stimulation?

A

uses a focused magnetic current to stimulate specific areas of the brain. Allows you to observe behaviour changes as a result of brain stimulation.

33
Q

What are nodes of Ranvier?

A

Nodes of Ranvier are gaps between secions of myelin where the axon is exposed. It the difference between the exposed axon membrane and the myelin that help move action potentials so fast