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Robbins > Chapter 1 rounds > Flashcards

Chapter 1 rounds Flashcards

1
Q

DICER

A

DICER trims and processes primary microRNA

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2
Q

RISC

A

RNA induced silencing complex: multiprotein aggregate assocaites with mature ss microRNA to target mRNA for cleavage and repress translation

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3
Q

XIST

A

Long noncoding RNA transcribed from x chromsome: essential in physiologic X chromosome inactivation: gene silencing

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4
Q

Phosphatidylserine

A

Inner leaflet of cell membrane, when flipped to extracellular surface cell undergoes apoptosis.

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5
Q

Endocytosis mechanisms

A
  1. Caveolae: plasma membrane invaginations (potocytosis)

2. Clathrin: receptor mediated endocytosis (pinocytosis)

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6
Q

List intermediate filaments (6)

A 
Lamin A, B, C
Vimentin
Desmin
Neurofilaments
Flial fibrillary acidic protein
Cyotkeratins
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7
Q

Occluding junction examples (4)

A

Complexes composed of transmembrane proteins:

Claudin, occludin, zonulin, catenin

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8
Q

Spot desmosomes function and examples

A

Macula adherens
Desmoglein and desmocolin (cadherins): linked to intracellualr intermediate filaments allow forces to be communicated over multiple cells

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9
Q

The warburg effect

A

upregulate glucose and glutamine cell uptake and decreased ATP per glucose molcule.

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10
Q

Second messenger examples (7)

A 
Calcium
cAMP
cGMP
inositol triphosphate
Diacylglycerol
arachodonic acid
nitric oxide
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11
Q

TGF beta family proteins (4)

A

bone morphogenic proteins
activins
inhibins
mullerian inhibiting substances

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12
Q

basement membrane composition

A

Collagen 4 and laminin:

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13
Q

Fibrillar collagens (4)

A

type 1,2,3,5

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14
Q

Fibrillar collagen defects examples (2)

A
  1. osteogenesis imperfecta

2. Ehlers danlos syndrome

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15
Q

Adhesive glycoproteins (3)

A
  1. fibronectin
  2. laminin
  3. integrins
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16
Q

Most important checkpoint for DNA integrity before irreversible replication

A

G1-S checkpoint

17
Q

Check point that ensures accurate genetic replication

A

S-G2 checkpoint

Robbins (2 decks)

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