Chapter 1: Introduction to Physiology Flashcards

1
Q

What is the study of phsyiology?

A

The study of the normal functions of living organisms and its component parts which includes the chemical and physical processes

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2
Q

What kind of science is physiology and why?

A

Physiology is an integrative science because it includes body functions over all the levels of organization as well as the fields of study that overlap with these levels of organizations

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3
Q

What are emergent properties? Give an example.

A

Emergent properties are properties that’s function cannot be predicted with just the individual parts/components. For example, human emotion and intelligence cannot be predicted by knowing everything about nerve cells. Same goes for a car and its parts, you cannot predict that a pile of metal, nuts and bolts, and chips, could come together to make a vehicle that can convert gasoline to energy and fuel.

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4
Q

What was the Human Genome Project?

A

Scientists thought that by coding the entire genome of a human, they would know everything there is to know about the body and functions. They thought that one gene coded for one protein, but it turned out that one gene actually coded for many proteins. The project was abandoned in 2003.

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5
Q

To understand physiology, you also need to have an understanding of?

A

Physiology cannot exist without anatomy. The structures of cells/tissues/organs need a physical body for its functions.

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6
Q

What are the levels of organization from basic to complex?

A

Atom - Molecules - Cells - Tissues - Organs - Organ Systems - Organisms - Populations of one species - Ecosystems of different species - Biosphere

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7
Q

How many organ systems are there and what are they?

A

There are 10 organ systems in the human body:

  • Integumentary system
  • Musculoskeletal system
  • Respiratory (pulmonary) system
  • Digestive (gastrointestinal) system
  • Urinary (renal) system
  • Reproductive system
  • Circulatory (cardiovascular system)
  • Nervous system
  • Endocrine system
  • Immune system
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8
Q

What is the function of a physiological system or event? What kind of approach is this considered?

A

The function is the “why” of a system/event, asking about the adaptive significance of a system/event is taking a teleological approach.

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9
Q

What is the mechanism of a physiological system or event? What kind of approach is this considered?

A

The mechanism is the “how” of a system/event, asking about the process of a system/event is taking a mechanistic approach.

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10
Q

What is translational research?

A

Translational research is when you use the results from basic biomedical research to help develop treatment for humans.

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11
Q

What are the five major themes of physiology?

A
  1. Structure and function
  2. Energy transfer, use, and storage
  3. Information flow, storage, and use
  4. Homeostasis
  5. Evolution
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12
Q

What is homeostasis?

A

The way that organisms keep their internal environment stable by monitoring the body and taking corrective actions when the levels are disrupted.

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13
Q

Who came up with the concept of homeostasis?

A

French physician Claude Bernard in the mid 1800s

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14
Q

What are the two types of variables that are under homeostatic control?

A
  • Environmental factors that affect the cell such as temperature, pH, and osmolarity
  • Materials for cell needs such as nutrients, water, etc
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15
Q

What happens if the body fails to maintain homeostasis?

A

The body will enter a disease state and develop a pathological condition.

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16
Q

What are the two general groups of diseases and how are they caterogrized?

A

They are categorized through their origin, and the two groups are:

  • caused by internal failure
  • caused by an originate source
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17
Q

What is the extracellular fluid?

A

The extracellular fluid is the buffer between cells and the outside world.

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18
Q

What is the intracellular fluid?

A

The intracellular fluid is the fluid that is located inside of the cells.

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19
Q

To maintain homeostasis, what must the body do?

A

The body must maintain mass balance.

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20
Q

What does the law of mass balance state?

A

The law of mass balance states that for the amount of substances in the body to be constant, there should be an equal loss for every gain.

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21
Q

What is the body’s “load”?

A

The amount of substance in the body.

22
Q

What is the law of mass balance equation?

A

Total amount of substance x in the body = intake + production - excretion - metabolism

23
Q

What are the two options the body can take to maintain mass balance? Briefly define each option.

A
  • One option is excretion which eliminates materials from the body through urine, feces, lungs, or skin.
  • The other option is metabolism which converts a substance to a different substance.
24
Q

What is mass flow, and how do scientists use it?

A

Mass flow is the rate of how a substance travels throughout the body or in and out of it. Scientists use mass flow to keep track and follow materials throughout the body.

25
Q

What is the mass flow equation?

A

Mass flow = concentration of x times volume flow

amount x/min) = (amount x/vol) x (vol/min

26
Q

What is clearance? What is it an indirect measure of?

A

Clearance is the rate at which materials/substances are eliminated or disappear from the blood. It indirectly measures how the body handles substance x. However, clearance does not tell you where the substance is going, just the rate at which it’s cleared.

27
Q

What are the primary organs that clear solutes from the body?

A

The kidney and liver.

28
Q

Why do pharmaceutical companies need to know clearance of the chemicals they’re testing?

A

To know the proper dosing schedule.

29
Q

How does homeostasis relate to the ECF?

A

Homeostasis is trying to maintain the stability of the ECF.

30
Q

What kind of state are the ECF and ICF in? Explain.

A

Disequilibrium, dynamic steady state. The ECF and ICF don’t have the same concentrations of each substance(s). ECF has high concentrations of Na+ and Cl-, and low concentrations of K+. ICF has high concentrations of K+ and low concentrations of Na+ and Cl-.

31
Q

What is the setpoint?

A

Optimum value.

32
Q

What are the three components that all control systems have?

A
  1. Controller
  2. Integrating center
  3. Output signal
33
Q

What is the simplest form of control? Explain it briefly.

A

The simplest form of control is local control, where it only involves nearby tissues and cells.

34
Q

What is a more complex form of control? Explain it briefly.

A

A more complex form of control is reflex control that is used for more long distance pathways.

35
Q

What are the two parts of a psychological reflex?

A

Response loop and feedback loop.

36
Q

What is the pathway for a reflex pathway? What is it also known as?

A

Stimulus - Sensor - Input Signal - Integrating Center - Output Signal - Target - Response
It is also known as the response loop.

37
Q

What is antagonist control? Give an example.

A

When two components work in opposition to each other, such as the heater and air conditioner.

38
Q

What does the feedback loop do?

A

The feedback loop brings pathway back to the stimulus, ensuring that the response doesn’t exceed its target. This back and forth between the stimulus and response causes a regulated variable that oscillates around the setpoint.

39
Q

What is a negative feedback loop?

A

Negative feedback is when the regulated variable is brought back to the setpoint. Negative feedback helps stabilize the variable and help with homeostasis.

40
Q

What is a positive feedback loop?

A

Positive feedback is when the regulated variable goes further away from the setpoint. It reinforces the stimulus and disrupts homeostasis.

41
Q

What is a feedforward control?

A

Feedforward control is an anticipatory response to change that the body might undergo.

42
Q

What are biological rhythms?

A

Regulated variables that have predicted changes and create patterns or rhythms

43
Q

What is acclimatization?

A

Acclimatization is adapting to physiological processes in new/different environment conditions.

44
Q

What is acclimation?

A

Acclimatization that happens artificially in a laboratory.

45
Q

What is a crossover study?

A

When the participants act as both the experimental subjects and control. This is used to reduce human variability in test populations.

46
Q

What is a blind study?

A

When the subjects do not know if they are receiving the treatment or placebo.

47
Q

What is a double blind study?

A

When both the researchers and subjects do not know if they are receiving the treatment or placebo.

48
Q

What is a crossover double blind study?

A

A double blind study where the participants switch between the experimental subject and control.

49
Q

What are longitudinal studies?

A

Studies that are meant to be carried out for a long period of time such as the Framingham Heart Study.

50
Q

What are cross-sectional studies?

A

Studies that survey a population for the prevalence of a disease or condition.

51
Q

What are retrospective studes?

A

Studies that match groups of people who all have a particular disease to a similar but healthy control group.

52
Q

What is a meta-analysis?

A

Meta-analysis is used to resolve contradictory results bu combining all the data from a group of similar studies and uses statistics to find significant trends and findings.