Chapter 1 - Amino Acids, Peptides, and Proteins Flashcards

1
Q

Structure of an amino acid

A
  • carboxyl group, amino group (NH2), a hydrogen, and an R group, all attached to an alpha carbon
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2
Q

Which amino acid is achiral?

A
  • Glycine (R group is an H)
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3
Q

What is the one chiral amino acid that is in R configuration instead of S?

A
  • Cysteine (R group is a CH2SH group and takes priority over carboxyl group)
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4
Q

Alanine R-group

A
  • 1 Carbon
  • A (Ala)
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5
Q

Valine R-group

A
  • 2 Carbons
  • V (Val)
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6
Q

Leucine R-group

A
  • 3 Carbons
  • L (Leu)
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7
Q

Isoleucine R-group

A
  • 4 Carbons
  • I (Ile)
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8
Q

Methionine R-group

A
  • 2 Carbons, S, then another Carbon
  • M (Met)
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9
Q

Proline R-group

A
  • forms cyclic amino acid
  • nitrogen becomes part of a 5-membered ring ( 3 Carbons in R-group)
  • P (Pro)
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10
Q

Tryptophan R-group

A
  • double ring system including another nitrogen
  • W (Trp)
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11
Q

Phenylalanine R-group

A
  • benzyl group (benzene ring + CH2 group)
  • F (Phe)
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12
Q

Tyrosine R-group

A
  • benzyl group (benzene ring + CH2 group) + Hydroxyl group off the ring
  • Y (Tyr)
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13
Q

Serine R-group

A
  • two carbons + hydroxyl group
  • hydroxyl group is on tertiary carbon
  • S (Ser)
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14
Q

Threonine R-group

A
  • two carbons + hydroxyl group
  • hydroxyl group is on first carbon of R group
  • T (Thr)
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15
Q

Asparagine R-group

A
  • amide group and 1 carbon
  • N (Asn)
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16
Q

Glutamine R-group

A
  • amide group and 2 carbons
  • Q (Gln)
17
Q

Cysteine R-group

A
  • thiol group (SH) and 1 carbon
  • C (Cys)
18
Q

Aspartate

A
  • 1 carbon and a carboxylate (COO-)
  • D (Asp)
19
Q

Glutamate

A
  • 2 carbons and a carboxylate group (COO-)
  • E (Glu)
20
Q

Lysine R-group

A
  • terminal primary amino group
  • K (Lys)
21
Q

Arginine R-group

A
  • has 3 nitrogens in side chain
  • R (Arg)
22
Q

Histidine R-group

A
  • aromatic ring with 2 nitrogen atoms
  • H (His)
23
Q

Hydrophobic amino acids

A
  • have long alkyl side chains
  • alanine, isoleucine, leucine, valine, phenylalanine
24
Q

Hydrophilic amino acids

A
  • charged side chains
  • histidine, arginine, lysine (positively charged)
  • glutamate and aspartate (negatively charged)