chapter 1 Flashcards
2nd most common risk factor for breast cancer
Benign breast disease
Atypical lesion in breast- what is relative risk
RR: 3-5
LCIS what is relative risk
RR: 3-5
Which Risk models are used
Gail 5 year risk- NCI designed model
What is the historic number on Gail risk model
1.66
What is NSABP-1
Women with Gail risk more than 1.66- Tamoxifen or not?
Side effect of Tamoxifen on eyes
Cataracts
STAR trial- what was it
Raloxifen vs Tamoxifen. Tamoxifen was slightly better in the long term follow up
Where will use Raloxifene.
Post menopausal women with intact Uterus.
Exemestane study
Only for post menopausal women.
IBIS-II trial
looked at Anastrazole
Where will you use prevention measures
Atypical lesions, LCIS, Gail risk > 1.66 and DCIS and remaining tissue.
When should mammogram start
General population- 40 years of age, every 2 years
High risk population- start at 30 or 5-10 years prior to the earliest age of family member.
Clinical breast exam- when do they start
women in 20-30 every 3 years. every year after 40 years of age.
screening MRI
- personal BRCA mutation
- First degree relative with BRCA mutation
- Atypical breast lesion
- Lifetime risk greater than 20-25% (BRCAPRO or other models)
- RT to chest between age 10-30
- Li-Fraumeni syndrome and first degree relatives
- Cowden syndrome (p10)
- Bannayan-Riley-Ruvalcaba syndrome syndrome.
