Chapter 1 Flashcards
Dose volume
Normal dose (mCi) / A.f (mCi/ml)
PEDI calculation rule by who?
Clack’s rule
How to cal PEDI dose
Kid’s Lb/150 x normal adult dose
What is pharmaceutical?
Substance given to living organism that may modify one or more its functions
What is Radiopharmaceutical?
A radioactive drug that can be administered safely to humans for diagnostic and therapeutic purposes.
90% of all Rp are used for
Diagnostically
Diagnostic Rp determine
A particular disease or syndrome
(T.e) effective half life….. than physical (T.p) and biological (T.b) half life.
Shorter
Calculate the effective half life (T.e)
Te=(TpxTb)/(Tp+Tb)
Characteristics of Diagnostic Rp
1) Short half life
2) Minimal activity
3) NO particulate emissions
4) Decay by electron capture or isomeric transition
5) High target to non-target ratio
6) Available
7) No drug effects
What is therapeutic Rp
Given to remedy the disease or syndrome previously diagnosed.
Characteristics of therapeutic Rp
1) Long half life
2) Medium - High activity
3) Beta emitter
4) Kill cells
I-131 (or In-111) can be used diagnostically and therapeutically depend on….?
Low dose?
High dose?
▶️The dose◀️
_low dose 10-30 uCi ➡️ Diagnostic
_high dose 10-200 mCi ➡️ Therapeutic
Activity concentration
The amount of radioactivity per volume (mCi/ml)
Specific activity
The amount radioactivity per mass (mCi/mg)
Biodistribution
Radiopharmaceutical localization
Calibration time
The time which the activity concentrating is determined
Carrier
A stable form of the radionuclide of the same element
Carrier free - NCA
No carrier added, no stable element is used in the process
Chelate
A substance, atoms accept 2 or more electron pairs to fill its outer shell
Example of chelate
Tc-99m-MDP, DTPA
1 mCi = ? MBq
1 mCi = 37 MBq
1 Bq = dimension per …..
Dimension per second
Deuteron
1 proton + 1 neutron
Ion-
An atom or atoms become electrostatically charged by Gaining or Losing electrons
Covalent compound
Compound formed by the SHARING of electron rather than the transfer of e-
Pyrogens
Fever producing substances
Solvent
Material is used to dissolve a solute
Solute
Substance dissolved in a solvent
Solution
Example?
One phase mixture of a solvent and solute where the two cant be discerned
Example: DTPA
Suspension
Example?
A liquid which small particles are dispersed but not dissolved.
Example: MAA, sulfur colloid
Colloidal suspension
A dispersion of a substance in a liquid where the size of particles are 10 mm to 1um (micron)
Sterile
Free from viable or living organisms.
