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Blood Bank > Chapter 1-3 > Flashcards

Chapter 1-3 Flashcards

1
Q

Produces antibodies

A

Plasma cells

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2
Q

Class HLA II antigens

A

Macrophages
Dendritic cells
B-cells

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3
Q

HLA class I antigens

A

Platelets
Leukocytes
Most nucleated cells in the body

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4
Q

Epitope

A

Part of antigen recognized by a corresponding antibody or receptor
-known as antigenic determinant
-responsible for specificity
-

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5
Q

Lipid

A

Least immunogenicity

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6
Q

Protein

A

Most immunogenicity

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7
Q

Hem agglutination test

A
  • Antigen on red cell

- Enhanced by increasing incubation time

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8
Q

Opsonins

A

Molecules that bind to antigen to increase phagocytosis

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9
Q

Way to prevent GVHD

A

Irradiation of the blood product

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10
Q

Complement activation results in

A

Cell lysis
Enhanced cell clearance
Neutrophil activation
Generation of vasoactive amines

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11
Q

MLC technique

A

Determine HLA-D antigens and compatibility

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12
Q

IgA

A

Found in mucosal linings

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13
Q

IgG

A

Able to cross placenta

  • highest serum plasma concentration
  • detected with anti globulin test
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14
Q

IgM

A

10 antigen binding sites

  • produced early in immune response
  • pentameter shape
  • activates complement cascade most efficiently
  • intravascular cell destruction
  • immediate spin
  • room temp
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15
Q

IgE

A

Allergic reaction

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16
Q

Phagocytes

A

APC

PMN

17
Q

Lymphocytes

A

T cell

B cell

18
Q

Antigen

A

Any substance ( usually foreign) that combines with an antibody or binds to a T cell

19
Q

Immunogen

A

Antigen in its role of eliciting an immune response

- can have multiple epitope and produce multiple antibodies of varying specificity

20
Q

Allotype

A

Parts of antibody that are common to host

Ex: IgG heavy chain allotrope

21
Q

Isotope

A

IgG class

Heavy chain

22
Q

Idiotype

A

Specific to antigen stimulating the response

Ex: complementary determining regions of antibodies are unique

23
Q

Primary response

A

Lag phase 5-7 days

  • initial exposure to antigen
  • Ab rise,plateau, decline
  • IgM followed by IgG
24
Q

Secondary response

A

Ab production 1-2days
Memory B cells
Ab levels higher and sustained longer
- IgG

25
Q

Prozone

A

Antibody excess

26
Q

Postpone

A

Antigen excess

27
Q

Idiotype

A

Variable region on immunoglobulin

28
Q

Hinge region

A

Imports flexibility to the immunoglobulin

29
Q

Kappa

A

Light chain

30
Q

Haplotypes

A

When two genes are close together on the same chromosome and are inherited genes as in most blood group system

31
Q

Polymorphic

A

Having two or more alleles at a given gene locus

32
Q

Recessive

A

When a gene product is expressed only when it is inherited by both parents

Blood Bank (1 decks)

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