Chapter 1 Flashcards

0
Q

It was the principal obstacle to overcome.

A

Clotting

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1
Q

In 1942, blood was taken from three young men and given to______ in the hope of curing him.

A

Pope Innocent VII

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2
Q

Attempts to find nontoxic anticoagulant began in __?

A

1869

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3
Q

He recommended sodium phosphate.

A

Braxton Hicks

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4
Q

First example of blood preservation rsearch.

A

Sodium phosphate

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5
Q

In 1901, he discovered the ABO blood groups and he explained the serious rxns that occur in humans as a result of incompatible transfusions.

A

Karl Landsteiner

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6
Q

He carried out vein-to-vein transfusion of blood by using multiple syringes and a special cannula for puncturing the vein through the skin.

A

Edward E. Lindemann

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7
Q

He designed his syringe-valve apparatus that transfusions from donor to patient by an unassisted physician became practical,

A

Unger

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8
Q

In 1914, he reported the use of sodium citrate as as anticoagulant solution for transfusions.

A

Hustin

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9
Q

In 1915, he determined the minimum amount of citrate needed for anticoagulation and demonstrated its non-toxicity in small amounts.

A

Lewisohn

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10
Q

Early as 1916 when they introduced a citrate dextrose solution for the preservation of blood .

A

Rous and Turner

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11
Q

His pioneer work during World War II on developing techniques in blood transfusion and blood preservation led to establishment of a widespread system of blood banks.

A

Dr. Charles Drew

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12
Q

He was appointed director of the first American Red Cross blood bank at Presbvterian Hospital.

A

Dr. Charles Drew

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13
Q

In 1943, they introduced the formula for the preservative acid-citrate-dextrose (ACD).

A

Loutit and Mollison of England

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14
Q

He introduced an improved preservative solution called ______ (CPD) which was less acidic and eventually replaced ACD as the standard preservative used for blood storage.

A

Gibson, citrate-phosphate-dextrose

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15
Q

A volunteer donor can donate blood every ________

A

8 weeks

16
Q

What are the Three steps or processes of donation process?

A

Educational reading materials
The donor health history questionnaire
Abbreviated physical examination

17
Q

Plasma can be converted by ______ to a clotting factor concentrate that is rich in ______.

A

Cryoprecipitation

AHF antihemophilic factor

18
Q

Whole blood can be separated into three components. What are they?

A

Packed RBCs, platelets, plasma

19
Q

For a 110 pound donor, what is the maximum volume collected?

A

525 ml

20
Q

These are used when collecting 500ml of blood, with the volume of anticoagulant preservative solution being increased from 63 ml to 70 ml.

A

Modified plastic collection system

21
Q

How many days is a unit of whole blood prepared RBCs stored?

A

21-42 days

22
Q

What is the total blood volume of most adults?

A

10 to 12 pints

23
Q

Donor’s red cells are replaced within________ after donation.

A

1-2 months

24
Q

How many screening tests are performed on each unit of donated blood?

A

10

25
Q

It is one of the reason why there is an increased safety of the blood supply.

A

NAT nucleic acid amplification testing

26
Q

3 areas of RBC that are crucial for normal erythrocyte survival and function:

A

Normal chemical composition and structure of rbc membrane, HGB structure and function, RBC metabolism

27
Q

The main lipid components of the rbc membrane.

A

Phospholipids

28
Q

Proteins that extend from the OUTER surface and span the entire membrane to the INNER cytoplasmic side of the RBC

A

Integral membrane proteins

29
Q

A second class of membrane proteins that is located and limited to the cytoplasmic surface of the membrane forming the RBC CYTOSKELETON.

A

Peripheral proteins

30
Q

External cytoplasmic layer of RBC is rich in ___ and ____ while internal cytoplasmic layer is rich in _____.

A

Glycolipids and choline phospholipids

Amino phospholipids

31
Q

What is the biochemical composition of RBC membrane?

A

Protein 52%
Lipid 40%
Carbohydrate 8%