Chapter 1 Flashcards
The original concept of Neuroglia was formed by?
Rudolf Virchow (mid 1800’s)
PNS neuroglia arises from?
From the neural crest, classified into Schwann cells, satellite glial cells, olfactory ensheathing cells and enteric glia.
CNS neuroglia arises from?
macroglia cells (ectodermal, neuroepithelial origin, microglia cells (mesodermal, myeloid origin).
Macroglia can be divided or classified into?
astroglia, oligodendroglia, NG-2 glia (oligodendrocyte progenitor cells).
The total number of neuronal and non-neuronal cells is about equal? True or False
True - they are almost on par with each other. Evolutionarily, this balanced ratio suggests their importance, but over time, they trended towards an increase in the ratio, thus hinting at their performance in critical cerebral functions with the largest amounts observed in whales and elephants.
The unifying fundamental function of all types of glial cells is?
The maintenance of the homeostasis of the nervous system.
Microglia permanently reside in the CNS? True or False
True - and they originate from a mesodermal source, and of myeloid origin, colonizing the CNS early in evolution, and are conserved across species.
Microglia have a main function, what is it?
They are the resident macrophages of the brain, so their serve a heavy defensive function via their phagocytic abilities that can produce many pro/anti-inflammatory factors.
Does this remodeling of synapses affect processes other than homeostasis?
Yes, this modulation of synaptic overall numbers and activity affects the processes of learning, memory and critical cognitive functions.
Through phagocytosis, microglia can?
incorporate waste products, cellular debris and pathogens.
Microglia are not fundamental for brain development, activity and plasticity? True or False
False, microglia are super important in all of these functions, along with the creation and remodeling of synapses.
Any other details microglia regulate?
Yes, they regulate neurogenesis, neuronal density, neuronal connectivity, along with neuronal survival and turnover.
If microglia are constantly surveying the environment, are there areas where they are particularly abundant?
Yes, their activities show a proclivity in regions where debris, apoptotic expression, along with areas of high density and neuronal turnover (particularly during development)
Where do oligodendrocytes originate from?
OPC’s (oligodendrocyte precursor cells) that arise from multipotent neural stem cells (mNSC’s) which mostly originate from ventricular areas of the brain where they migrate to the developing CNS becoming active.
Why does the differentiation between NG-2 glia and oligodendrocytes matter?
This differentiation is important for myelin repair in the adult brain, along with ensheathing new neuronal connections with myelin in response to new experiences.