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haema > chapter 1 > Flashcards

chapter 1 Flashcards

1
Q

what is the meaning of haemaoiesis

A

process of formation of blood

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2
Q

where does blood formation in adults

A

bone marrow. midline flex

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3
Q

what are the key elements

A
  1. bone marrow microenviro
  2. cytokines
  3. nutrients
  4. hormones
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4
Q

hormones that was made from liver for haempoesis

A

thrombopoetin ; kidney-arythropoeitin

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5
Q

what is the regulator for erythropoiesis

A

erythropoeitein

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6
Q

iron dependence

A

3-4 days

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7
Q

ERYHTROPOESIS

A

stem cells- bfu-cfu

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8
Q

monocyte berenti sampai mana je?

A

sampai blood je,

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9
Q

monocyte can differentiate jadi apa

A

macrophages foun in tissue takes several months or year before ded

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10
Q

granulocytes

A

6-10 days in bone marrow n 6-10 hrs in blood

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11
Q

lymphopoeisis

A

form bone marrow, pergi thrombin (t cells mature kat situ) nk cells and b cells

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12
Q

thrombopoeisis

A

mk cells

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13
Q

duration of maturation of mk cells

A

10days

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14
Q

mk cells jadi…..

A

platlets

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15
Q

buffer contains

A

platlets n wbc

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16
Q

platlets

A

anucleate cells, discoid, 7-10 days,

17
Q

platlets in volves in

A

primary haemostasis

18
Q

end product or formation of…..

A

unstable paletlet plug kalau injury

19
Q

our body benefits from platlets

A

during endothelial injury

20
Q

majority clotting fac synthesised in

A

liver

21
Q

coagulation composed of

A

clotting fac

22
Q

does clooting fac it in active or inactive form

A

inactive form in plasma bcs the blood will keep coagulate kalau dalam active form

23
Q

bila clotting fac active?

A

when injury

24
Q

what major role in secondary haemostasis?

A

coagulation

25
Q

end product coagulation

A

stable fibrin/ plug clot

26
Q

coagulation with shortest halflife

A

5hrs coagulations fac 7 (vii)

27
Q

nak coagulate darah dalam lab kena ada

A

phospholipid n calcium

28
Q

phases of secondary haemostasis

A
  1. initiation

2. amplification

29
Q

active form of clotting fac

A

i=enzyme serine protease

30
Q

final phase of haemostasis

A

fibrinolysis

31
Q

fx of fibrinolysis

A

to lysis the fibrin clot afterinjury repaired

32
Q

what is the keyplayer in fibrinolysis

A

plasminogen (inactive form) beta globulin proenzyme

33
Q

ACTIVE FORM OF PLASMINOGEN

A

plasmin after converted by tpa, clotting fac and kallikrein

34
Q

end product of fibrinolysis

A
  1. fibrinogen degradation product (fdp)

2. d dimer

35
Q

fx of plasmin

A

digest fibrinogen, fibrin clotting fac and protein

36
Q

tpa diactivekan/ kerja bila kena trigger dengan

A

PAI

37
Q

fx of TAFI thrombin activated fibrinolysis inhibitor

A

inhibit fibrinolysis process

38
Q

where the fdp went?

A

reticuloendothelial system pergi kidney or liver

haema (3 decks)

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