chapter 1 Flashcards
what is the meaning of haemaoiesis
process of formation of blood
where does blood formation in adults
bone marrow. midline flex
what are the key elements
- bone marrow microenviro
- cytokines
- nutrients
- hormones
hormones that was made from liver for haempoesis
thrombopoetin ; kidney-arythropoeitin
what is the regulator for erythropoiesis
erythropoeitein
iron dependence
3-4 days
ERYHTROPOESIS
stem cells- bfu-cfu
monocyte berenti sampai mana je?
sampai blood je,
monocyte can differentiate jadi apa
macrophages foun in tissue takes several months or year before ded
granulocytes
6-10 days in bone marrow n 6-10 hrs in blood
lymphopoeisis
form bone marrow, pergi thrombin (t cells mature kat situ) nk cells and b cells
thrombopoeisis
mk cells
duration of maturation of mk cells
10days
mk cells jadi…..
platlets
buffer contains
platlets n wbc
platlets
anucleate cells, discoid, 7-10 days,
platlets in volves in
primary haemostasis
end product or formation of…..
unstable paletlet plug kalau injury
our body benefits from platlets
during endothelial injury
majority clotting fac synthesised in
liver
coagulation composed of
clotting fac
does clooting fac it in active or inactive form
inactive form in plasma bcs the blood will keep coagulate kalau dalam active form
bila clotting fac active?
when injury
what major role in secondary haemostasis?
coagulation
end product coagulation
stable fibrin/ plug clot
coagulation with shortest halflife
5hrs coagulations fac 7 (vii)
nak coagulate darah dalam lab kena ada
phospholipid n calcium
phases of secondary haemostasis
- initiation
2. amplification
active form of clotting fac
i=enzyme serine protease
final phase of haemostasis
fibrinolysis
fx of fibrinolysis
to lysis the fibrin clot afterinjury repaired
what is the keyplayer in fibrinolysis
plasminogen (inactive form) beta globulin proenzyme
ACTIVE FORM OF PLASMINOGEN
plasmin after converted by tpa, clotting fac and kallikrein
end product of fibrinolysis
- fibrinogen degradation product (fdp)
2. d dimer
fx of plasmin
digest fibrinogen, fibrin clotting fac and protein
tpa diactivekan/ kerja bila kena trigger dengan
PAI
fx of TAFI thrombin activated fibrinolysis inhibitor
inhibit fibrinolysis process
where the fdp went?
reticuloendothelial system pergi kidney or liver
