Chapter 05: Gene Therapy and Pharmacogenomics

Question 1

Which is the most important compound that transfers genes from parents to offspring?

a. Chromatin
b. Deoxyribonucleic acid (DNA)
c. Alleles
d. Ribonucleic acid

Answer 1

b. Deoxyribonucleic acid (DNA)

Question 2

Which is manufactured as a result of indirect gene therapy?

a. Vitamin K
b. epoetin (Eprex)
c. Human insulin
d. Heparin

Answer 2

c. Human insulin

Question 3

Eugenics is defined as
a. the use of gene therapy to prevent disease.
b. the development of new drugs based on gene therapy.
c. the intentional selection, before birth, of genotypes that are considered more
desirable than others.
d. the determination of genetic factors that influence a person’s response to
medications.

Answer 3

c. the intentional selection, before birth, of genotypes that are considered more
desirable than others.

Question 4

What is the main purpose of the Human Genome Project?

a. To study genetic diseases
b. To study genetic traits in humans
c. To discover new genetic diseases
d. To describe the entire genome of a human being

Answer 4

d. To describe the entire genome of a human being

Question 5

Genotyping for the presence of cytochrome P-450 2D6 (CYP2D6) enzymes and alleles will be
helpful in which area of medicine?
a. Cardiology
b. Psychiatry
c. Respirology
d. Oncology

Answer 5

b. Psychiatry

Question 6

Name one clinical application of pharmacogenomics.

Answer 6

Several possible clinical applications are listed in Table 5-1: Clinical Applications of
Pharmacogenomics.