Chap 5 slides

Question 1

Later stages of inflammation are the?

Answer 1

acute phase responses (APRs)

Question 2

Acute phase responses (APRs) are induced by proinflammatory cytokines?

Answer 2

IL-1, TNF-α, IL-6

Question 3

APR involves?

Answer 3

Increased synthesis/secretion of antimicrobial proteins by the liver

Question 4

Antimicrobial proteins by the liver?

Answer 4

Mannose Binding Lectin (MBL)
C-reactive Protein (CRP)
Complement components

Question 5

What proteins activate other processes that help eliminate pathogens?

Answer 5

Liver acute phase proteins

Question 6

Lymphocytes with innate immune functions?

Answer 6

NK cells

Question 7

NK cells Express a limited set of receptors for self-proteins induced by?

Answer 7

Infections
Malignant transformations
Other stresses

Question 8

Activated NK cells perform one of two functions?

Answer 8

Kill the altered self-cell

Produce cytokines that induce adaptive responses against the altered self-cell

Question 9

Activated NK cells, Kill the altered self-cell by releasing what two substances that induce apoptosis?

Answer 9

Perforin and Granzymes

Question 10

NK cells use what kind of receptors to distinguish between healthy and infected cells?

Answer 10

Activating and inhibitory

Question 11

What MHC class on normal cells are recognized by inhibitory receptors that inhibit signals from activating receptors.?

Answer 11

MHC 1 Class

Question 12

What happens to a cell that is missing MHC 1 class negative signal receptors?

Answer 12

Nk cell is activated by active receptor and kills cell lacking MHC 1 class

Question 13

NK cells expresses what TNF family of ligand on cell surface?

Answer 13

TNF receptor TRAIL

Question 14

TNF ligand family TRAIL binds and activate what on target cell?

Answer 14

DR4 DR5

Question 15

DR4 and DR5 VIA FADD activate cascape-8 which induces what?

Answer 15

Cell death

Question 16

NK-cell receptors belong to several structural families?

Answer 16

KIRs, KLRs, and NCRs

Question 17

Activating receptors that sense target cells?

Answer 17

NKp30
NKp44
NKp46
NKG2D

Question 18

Ligands for NKG2D are?

Answer 18

MIC-A/ MIC-B

RAET1 family

Question 19

MIC-A/ MIC-B RAET1 family ligands for NKG2D are triggered by?

Answer 19

Cellular stress

Question 20

Innate lymphoid cells (ILC) are derived from?

Answer 20

common lymphoid progenitor cells

Question 21

Innate lymphoid cells (ILC ) include what kind of cell and what population?

Answer 21

NK cells and ILC populations

Question 22

What cells are found in lymphoid tissue and recirculate?

Answer 22

NK cells

Question 23

NK cells found in lymphoid tissue and recirculate, other ILC mainly found in the?

Answer 23

Epithelium

Question 24

Each group of ILC based on ————- produced.

Answer 24

cytokines

Question 25

ILCs lack -------- and thus are not activated directly by -----------.

Answer 25

PRRs | pathogens

Question 26

ILC group 1 populations

Answer 26

NK cells | ILC1 cells

Question 27

ILC group 1 mediators for NK cells

Answer 27

INF-y TNF Perforin Granzymes

Question 28

ILC group 1 mediators for ILC1

Answer 28

IFN-y | TNF

Question 29

ILC group 2 population

Answer 29

ILC2 cells

Question 30

ILC group 2 mediators

Answer 30

``` IL-4 IL-5 IL-9 IL-13 Amphiregulin ```

Question 31

ILC group 3 populations

Answer 31

LTI cells ILC17 cells ILC22 cells

Question 32

ILC group 3 mediators LTI cells

Answer 32

Lt-Alpha LT-Bata IL-17A IL-22

Question 33

ILC group 3 mediators ILc17 cells

Answer 33

IFN-y | IL-17

Question 34

ILC group 3 mediators Ilc22 cells

Answer 34

IL-22

Question 35

Defects in ------- and ------------- increase susceptibility to ------------.

Answer 35

PRRs Signaling pathways Infections

Question 36

Regulation includes both Regulation includes both --------- and--------.

Answer 36

Positive and negative feedback mechanisms

Question 37

Innate systems have been co-opted by adaptive immunity to contribute to antibody-mediated pathogen elimination?

Answer 37

Opsonization | Complement activation

Question 38

Lymphocytes that express TLRs as -------- receptors.

Answer 38

costimulatory

Question 39

------ cells are a key bridge.

Answer 39

Dendritic cells

Question 40

Dendritic cells bring antigens from the site of infection and present them to the?

Answer 40

T cells in lymph nodes

Question 41

Once DC presents to the T-cells, this activates the T cells, allowing them to differentiate into particular pathogen-specific subsets for the best antigen clearance. What do the T-cells differentiate into?

Answer 41

Th cell | Tc cells

Question 42

Who showed that sheep antiserum to the bacterium Vibrio cholerae caused lysis (membrane destruction) of the bacteria, and that heating the antiserum destroyed its bacteriolytic activity. And ability to lyse the bacteria was restored to the heated serum by adding fresh serum that contained no antibacterial antibodies.

Answer 42

Jules Bordet

Question 43

who demonstrated the ability to lyse the bacteria was restored to the heated serum by adding fresh serum that contained no antibacterial antibodies.

Answer 43

Jules Bordet

Question 44

who showed the activity of blood serum that completes the action of antibody” and coined the term complement.

Answer 44

Paul Ehrlich

Question 45

Once complement system is activated, what are the multiple possible outcomes

Answer 45

Target cell membrane lysis Chemotaxis Opsonization to enhance phagocytosis Inflammation

Question 46

Three activation pathways exist.

Answer 46

Classical Lectin Alternative

Question 47

All three complement pathways generate ------, an important, multifunctional complement protein.

Answer 47

C3b