Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Immunology chap 5 test 2 > Chap 5 slides > Flashcards

Chap 5 slides Flashcards

1
Q

Later stages of inflammation are the?

A

acute phase responses (APRs)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Acute phase responses (APRs) are induced by proinflammatory cytokines?

A

IL-1, TNF-α, IL-6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

APR involves?

A

Increased synthesis/secretion of antimicrobial proteins by the liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Antimicrobial proteins by the liver?

A

Mannose Binding Lectin (MBL)
C-reactive Protein (CRP)
Complement components

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What proteins activate other processes that help eliminate pathogens?

A

Liver acute phase proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Lymphocytes with innate immune functions?

A

NK cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

NK cells Express a limited set of receptors for self-proteins induced by?

A

Infections
Malignant transformations
Other stresses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Activated NK cells perform one of two functions?

A

Kill the altered self-cell

Produce cytokines that induce adaptive responses against the altered self-cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Activated NK cells, Kill the altered self-cell by releasing what two substances that induce apoptosis?

A

Perforin and Granzymes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

NK cells use what kind of receptors to distinguish between healthy and infected cells?

A

Activating and inhibitory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What MHC class on normal cells are recognized by inhibitory receptors that inhibit signals from activating receptors.?

A

MHC 1 Class

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What happens to a cell that is missing MHC 1 class negative signal receptors?

A

Nk cell is activated by active receptor and kills cell lacking MHC 1 class

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

NK cells expresses what TNF family of ligand on cell surface?

A

TNF receptor TRAIL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

TNF ligand family TRAIL binds and activate what on target cell?

A

DR4 DR5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

DR4 and DR5 VIA FADD activate cascape-8 which induces what?

A

Cell death

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

NK-cell receptors belong to several structural families?

A

KIRs, KLRs, and NCRs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Activating receptors that sense target cells?

A

NKp30
NKp44
NKp46
NKG2D

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Ligands for NKG2D are?

A

MIC-A/ MIC-B

RAET1 family

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

MIC-A/ MIC-B RAET1 family ligands for NKG2D are triggered by?

A

Cellular stress

20
Q

Innate lymphoid cells (ILC) are derived from?

A

common lymphoid progenitor cells

21
Q

Innate lymphoid cells (ILC ) include what kind of cell and what population?

A

NK cells and ILC populations

22
Q

What cells are found in lymphoid tissue and recirculate?

A

NK cells

23
Q

NK cells found in lymphoid tissue and recirculate, other ILC mainly found in the?

A

Epithelium

24
Q

Each group of ILC based on ————- produced.

A

cytokines

25
Q

ILCs lack ——– and thus are not activated directly by ———–.

A

PRRs

pathogens

26
Q

ILC group 1 populations

A

NK cells

ILC1 cells

27
Q

ILC group 1 mediators for NK cells

A

INF-y
TNF
Perforin
Granzymes

28
Q

ILC group 1 mediators for ILC1

A

IFN-y

TNF

29
Q

ILC group 2 population

A

ILC2 cells

30
Q

ILC group 2 mediators

A 
IL-4
IL-5
IL-9
IL-13
Amphiregulin
31
Q

ILC group 3 populations

A

LTI cells
ILC17 cells
ILC22 cells

32
Q

ILC group 3 mediators LTI cells

A

Lt-Alpha
LT-Bata
IL-17A
IL-22

33
Q

ILC group 3 mediators ILc17 cells

A

IFN-y

IL-17

34
Q

ILC group 3 mediators Ilc22 cells

A

IL-22

35
Q

Defects in ——- and ————- increase susceptibility to ————.

A

PRRs
Signaling pathways
Infections

36
Q

Regulation includes both Regulation includes both ——— and——–.

A

Positive and negative feedback mechanisms

37
Q

Innate systems have been co-opted by adaptive immunity to contribute to antibody-mediated pathogen elimination?

A

Opsonization

Complement activation

38
Q

Lymphocytes that express TLRs as ——– receptors.

A

costimulatory

39
Q

—— cells are a key bridge.

A

Dendritic cells

40
Q

Dendritic cells bring antigens from the site of infection and present them to the?

A

T cells in lymph nodes

41
Q

Once DC presents to the T-cells, this activates the T cells, allowing them to differentiate into particular pathogen-specific subsets for the best antigen clearance. What do the T-cells differentiate into?

A

Th cell

Tc cells

42
Q

Who showed that sheep antiserum to the bacterium Vibrio cholerae caused lysis (membrane destruction) of the bacteria, and that heating the antiserum destroyed its bacteriolytic activity. And ability to lyse the bacteria was restored to the heated serum by adding fresh serum that contained no antibacterial antibodies.

A

Jules Bordet

43
Q

who demonstrated the ability to lyse the bacteria was restored to the heated serum by adding fresh serum that contained no antibacterial antibodies.

A

Jules Bordet

44
Q

who showed the activity of blood serum that completes the action of antibody” and coined the term complement.

A

Paul Ehrlich

45
Q

Once complement system is activated, what are the multiple possible outcomes

A

Target cell membrane lysis
Chemotaxis
Opsonization to enhance phagocytosis
Inflammation

46
Q

Three activation pathways exist.

A

Classical
Lectin
Alternative

47
Q

All three complement pathways generate ——, an important, multifunctional complement protein.

A

C3b

Immunology chap 5 test 2 (2 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions