Chap 4,6,7,8 Flashcards
The physiology of disordered function is?
Pathophysiology
The study of disease and its causes?
Pathology
Cellular adaptions
Atrophy
Hypertrophy
Hyperplasia
Metaplasia
Dysplasia
A decrease in cell size resulting from a decreased workload is?
Atrophy
An increase in cell size resulting from an increased workload is?
Hypertrophy
Enlargement
Dilation
An increase in the number of cells resulting from cell division caused by an increased workload is?
Hyperplasia
Cell division with division of the nucleus; each daughter cell contains the same number of chromosomes as the mother cell. ________ is the process by which the body grows?
Mitosis
Replacement of one type of cell by another type of cell that is not normal for that tissue is?
Metaplasia
A change in cell size, shape, or appearance caused by an external stressor is?
Dysplasia
Forms of cellular injury are?
Hypoxia
Chemicals
Infectious agents
Inflammatory reactions
Physical agents
Nutritional factors
Genetic factors
Oxygen deficiency is?
Hypoxia
A blockage in the delivery of oxygenated blood to the cells is?
Ischemia
As the cell becomes progressively more ischemic, the intracellular metabolism becomes?
Anaerobic ( without oxygen )
With anaerobic metabolism, there is a marked decrease in cellular ATP production and an increase in the production of harmful acids ( ketoacids ), primarily ?
Lactic acids
If oxygen is supplied to the cell in time, the injury is reversible true or false?
True
The result of cellular and tissue death is called?
Infarction
A microorganism capable of producing infection or disease is?
Pathogen
Constructive or building up phase of metabolism is?
Anabolism
The destructive or breaking down phase of metabolism is?
Catabolism
Response in which an injured cell releases enzymes that engulf and destroy itself; one way the body destroys and rids itself of damaged and dead cells.
Apoptosis
Cell death
Necrosis
Excess fluid in the interstitial space?
Edema
The liquid part of the blood is?
Plasma
Red blood cells which contain hemoglobin which transport oxygen to the cells is?
Erythrocytes
White blood cells which play a key role in the immune system and inflammatory ( infection fighting ) response?
Leukocytes
Platelets which are important in blood clotting?
Thrombocytes
An iron based compound that binds with oxygen and transports it to the cells is?
Hemoglobin
The percentage of the blood occupied by erythrocytes is?
Hematocrit
Intravenous fluids with the ability to transport oxygen is?
Hemoglobin-based oxygen-carrying solutions (HBOCs)
Substances, such as proteins or starches consisting of large molecules or molecule aggregates that disperse evenly within a liquid without forming a true solution is?
Colloids
A protein commonly present in plant and animal tissues?
Albumin
Substances capable of crystallization.
Crystalloids
A patient having a heart attack should be thought of as having_______?
Myocardial ischemia.
• Myocardial infarction is irreversible and we hope to intervene before this occurs.
__________ have electrolyte composition similar to the blood plasma?
Isotonic solutions
________Have a higher concentration than cells?
Hypertonic solutions
________ have a lower solute concentration than the cells.
Hypotonic solutions
_________ is an isotonic solution of sodium chloride, potassium chloride, calcium chloride, and sodium lactate in water.
Lactated Ringer’s
________ is an electrolyte solution of sodium chloride in water?
Normal Saline
_________ is a hypotonic glucose solution used to keep a vein open and to supply calories necessary for cell metabolism?
D5W
What two solutions are used for fluid replacement, because their administration causes an immediate expansion of the circulatory volume?
Lactated Ringer’s and Normal saline
•however as was noted, due to the movement of electrolytes and water, 2/3’s of either of these solutions is lost into the interstitial space within 1 hour.
Acidity caused by abnormal retention of carbon dioxide resulting from impaired ventilation is?
Respiratory acidosis
Alkalinity caused by excessive elimination of carbon dioxide resulting from increased respirations is?
Respiratory alkalosis
Acidity caused by an increase in acid, often because of increased production of acids during metabolism or from causes such as vomiting, diarrhea, diabetes or medication is?
Metabolic acidosis
Alkalinity caused by an increase in plasma bicarbonate resulting from causes including diuresis, vomiting, or ingestion of too much sodium bicarbonate is?
Metabolic alkalosis
An agent that increases urine secretion and elimination of body water is?
Diuretic
Inadequate pump (cardiogenic)
Inadequate fluid (hypovolemic)
Inadequate container (distributive/neurogenic)
Are all signs of ?
Physiological classifications of shock
Two characteristics of impaired cellular metabolism in any type of shock are ?
Impaired oxygen use and impaired glucose use
At the simplest level, shock is inadequate?
Tissue perfusion
The second stage of metabolism requiring the presence of oxygen in which the breakdown of glucose yields a high amount of energy is? ( aerobic means “with oxygen” )
Aerobic metabolism
The first stage of metabolism which does not require oxygen, in which the breakdown of glucose produces pyruvic acid and yields very little energy is ?
( anaerobic means “without oxygen” )
Anaerobic metabolism
Early stage of shock during which the body’s compensatory mechanisms are able to maintain normal perfusion is?
Compensated shock
Advanced stages of shock when the body’s compensatory mechanisms are no longer able to maintain normal perfusion is ? Also called progressive shock
Decompensated shock
Shock that has progressed so far that no medical intervention can reverse the condition and death is inevitable is?
Irreversible shock
Shock caused by insufficient cardiac output is?
Cardiogenic shock
Types of shock
•Cardiogenic •Hypovolemic •Neurogenic •Anaphylactic •Septic ( Alternative classifications of shock: ) • Cardiogenic • Hypovolemic • Obstructive • Distributive
The hallmark of Decompensated shock is ?
Fall in blood pressure
Most patients with Cardiogenic shock have a normal or _____________ blood pressure?
Increased
Shock caused by a loss of intravascular fluid volume is?
Hypovolemic shock
Greatly increased urination and dehydration due to high levels of glucose that cannot be reabsorbed into the blood from the kidney tubules, causing a loss of water into the urine is?
Osmotic diuresis
Shock resulting from brain or spinal cord injury that causes an interruption of nerve impulses to the arteries with loss of arterial tone, dilation, and relative Hypovolemia is?
Neurogenic shock
A life threatening allergic reaction?
Anaphylaxis also called ( Anaphylactic Shock )
Shock that developed as the result of infection carried by the bloodstream eventually causing dysfunction of multiple organ systems is ?
Septic shock
The study of drugs and their actions on the body is?
Pharmacology
what are the 4 different types of drug names?
- Chemical
- Generic
- Official
- Brand
Components of a Drug Profile
- Names
- Classifications
- Mechanism of action
- Indications
- Pharmacokinetics
- Side affects / adverse reactions
- Routes of administration
- Contraindications
- Dosage
- How supplied
- Special consideration
Six Rights of Medication Administration:
- Right person
- Right drug
- Right dose
- Right time
- Right route
- Right documentation
How a drug is absorbed, distributed, metabolized and excreted is ?(how drugs are transported into and out of the body)
Pharmacokinetics
How a drug interacts with the body to cause its effects is?
Pharmacodynamics
Most drugs travel through the body by means of?
Passive transport
Diffusion and osmosis are forms of ?
Passive transport
______ requires the use of energy to move a substance?
Active transport
The body absorbs most drugs faster when they given __________ than when they are given ___________?
- Intramuscularly
2. Subcutaneously
The amount of a drug that is still active after it reaches its target tissue is?
Bioavailability
The body’s breaking down chemicals into different chemicals is?
Metabolism
The liver’s partial or complete inactivation of a drug before it reaches the systemic circulation is?
First- pass effect
Delivery of a medication through the gastrointestinal tract is?
Enteral route
Delivery of a medication outside of the gastrointestinal tract, typically using needles to inject medications into the circulatory system or tissue is?
Parenteral route
Force of attraction between a drug and a receptor is their?
Affinity
A drug’s pharmacodynamics also involve its ability to cause the expected response , or?
Efficacy
A drug that binds to a receptor and causes it to initiate the expected response is?
Agonist
A drug that binds to a receptor but does not cause it to initiate the expected response is?
Antagonist
Unintended response to a drug is?
Side effect
The time from administration until a medication reaches its minimum effective concentration?
Onset of action
Minimum level of drug needed to cause a given effect is?
Minimum effective concentration
Length of time the amount of drug remains above its minimum effective concentration until it is eliminated from the body is?
Termination of action
Drug that best demonstrates the class’s common properties and illustrates its particular characteristics is?
Prototype
Nerve Cell?
Neuron
Medication that relieves the sensation of pain is?
Analgesic
The absence of the sensation of pain is?
Analgesia
The absence of all sensations is?
Anesthesia
Medication that induces a loss of sensation to touch or pain is?
Anesthetic
State of decreased anxiety and inhibitions?
sedation
Instigation of sleep?
Hypnosis
The part of the nervous system that controls involuntary actions?
Autonomic nervous system
Space between the nerves?
Synapse
Chemical messenger that conducts a nervous impulse across a synapse
neurotransmittter
Pertaining to the neurotransmitter acetylcholine?
Cholinergic
Pertaining to the neurotransmitter norepinephrine?
Adrenergic
drug or other substance that causes effects like those of the parasympathetic nervous system ( also called cholinergic )
Parasympathomimetic
drug or other substance that blocks or inhibits the actions of the parasympathetic nervous system ( also called anticholinergic )
Parasympatholytic
drug or other substance that causes effects like those of the sympathetic nervous system ( also called adrenergic )
sympathomimetic
drug or other substance that blocks the actions of the sympathetic nervous system ( also called antiadrenergic )
sympatholytic
drug used to treat and prevent abnormal cardiac rythms
antidysrhythmic
drug used to treat hypertension
antihypertensive
_______ is effective in the management of angina pectoris as it decreases cardiac work
Nitroglycerin
The stoppage of bleeding
hemostasis
drug that decreases the formation of platelet plugs
antiplatelet
drug that interrupts the clotting cascade
anticoagulant
drug that acts directly on thrombi to break them down ; also called thrombolytic
fibrinolytic
drug used to treat high blood cholesterol
antihyperlipidemic
agent that kills or decreases the growth of bacteria
antibiotic
Measures to decrease your risk of exposure to blood and body fluids
Standard precautions
A condition free of pathogens
Asepsis
Limited to one area of the body
Local
Throughout the body
Systemic
Free of all forms of life
Sterile
Cleansing agent that destroys or inhibits pathogenic organisms and is also toxic to living tissue is?
Disinfectant
Cleansing agent that destroys or inhibits pathogenic organisms but is not toxic to living tissue is?
Antiseptic
Needle handling precautions:
- Minimize tasks in a moving ambulance.
- Properly dispose of all sharps
- Recap needles only as a last resort