ch.8

Question 1

What doesn’t an early pro-B cell express

Answer 1

functional U protein

Question 2

What occurs during the Vh and DJj rearrangement in late pro B cells

Answer 2

: VH to DJH rearrangement occurs on one chromosome first → if no
functional H-chain is produced, VH to DJH rearrangement occurs on the
second chromosome

Question 3

During the late pro B cell phase if the cell failed to produce a functional H chain

Answer 3

cell death

Question 4

What does it mean to have a large pre-B cell

Answer 4

There is a pre-B cell recepto

Question 5

Small pre-B cell means

Answer 5

There is no surface Ig (L-chain gene rearrangement)

Question 6

Vk-Jk rearrangementn occurs first but if that is unsuccessful, what happens next?

Answer 6

Vl and Jl rearrangement occurs

Question 7

successful light-chain gene rearrangement produces

Answer 7

mIgM-Iga-Igβ on cell
surface

Question 8

What does BCR singaling trigger

Answer 8

cessation of L-chain gene rearrangement, failure to produce functional L chain leads to cell death

Question 9

Immature B cell

Answer 9

mIgM

Question 10

Mature B cell

Answer 10

mIgM and mIGD