Ch.4

Question 1

Griseofluvin, Tetracycline,fusidic acid, macrolides, polynene are antibiotics synthesised be…….pathway

Answer 1

Acetate pathway

Question 2

Penicillium griseofluvin produces…… antibiotics

Answer 2

Griseofluvin

Question 3

…..acetyl co a and….malonyl co a,are needed in griseofluvin synthesis.

Answer 3

1&6

Question 4

Griseofluvin contains Cl atom..while,griseooanthrone C (griseofluvin) does not….true or false

Answer 4

True

Question 5

Griseofluvin is an anti……,that wworks by inhibiting…….

Answer 5

Antifungal,miotic spindles

Question 6

Griseofluvin has no side effects,while Tetracycline has..

Answer 6

True

Question 7

Dermatophytosis (Trichophyton, Microsporum, and Epidermophyton.),skin, hair, nails can be treated by…

Answer 7

Griseofluvin antibiotics.

Question 8

Griseofluvin can’t be applied….and it is well absorbed by….

Answer 8

Topically,gut

Question 9

Griseofluvin can be used when antifungal…..habe not worked

Answer 9

Creams

Question 10

One ….and …malonyl co a are needed for Tetracycline synthesis..

Answer 10

malonamyl co,8

Question 11

Streptomyces aureofaciens and Streptomyces rimosus preduces… antibiotics

Answer 11

Tetracycline

Question 12

Tetracycline is a
…… spectrum activity and works by ……

Answer 12

broad,protein synthesis inhibiting

Question 13

…. and ….. groups make tetracycline amphoteric, and are more stable in… media thus absorbed …

Answer 13

Phenolic,amino,acidic and orally.

Question 14

Tetracyclines … and … groups make their chelating properties, thus it’s advised not to take them with dairy products that contain …and anti acids that contain …and…

Answer 14

phenolic,carbonyl
Ca, Mg, and Al

Question 15

Doxycycline and minocycline are ….antibiotics,that are…affected by metal ions

Answer 15

Semi synthesised less

Question 16

bones and teeth defects, kidney toxicity and hepatotoxicity…are side effects of ….. antibiotics

Answer 16

Tetracycline

Question 17

… and … are the most commonly prescribed Tetracycline agents.

Answer 17

Tetracycline,oxytetracycline

Question 18

Tetracyclines routes of administration..

Answer 18

Orally,locally, drops,and injection

Question 19

Doxycycline is used as a prophylactic against …

Answer 19

malaria

Question 20

Chronic bronchitis (against haemophilus influenza) and acne (systemically) …arother indications for..

Answer 20

Tetracyclines

Question 21

… is a steroidal antibiotic produced by …( fungus)

Answer 21

Fusidic acid,Acremonium fusidioids

Question 22

Fusidic acid mechanism:

Answer 22

Protein synthesis inhibitor( bacteriostatic)

Question 23

Fusidic acid often used as …and…and eye drops but may also be given as….or….

Answer 23

Creams and eye drops
Tablets and injections

Question 24

Fusidic acid is a ….spectrum,gram …. bacteria

Answer 24

Narrow, positive

Question 25

Fusidic acid concentrates in bones.....so it can be used in..

Answer 25

Osteomyelitis

Question 26

Fusidic acid usually is being used in combination with other antibiotics to...

Answer 26

Minimize resistance

Question 27

Macrolide antibiotics are synthesised by.....spp

Answer 27

Streptomyces

Question 28

It contains large......ring

Answer 28

Lactone(12.14.16.17) atoms

Question 29

Macrolide structure contains numerous..... substitution in lactone ring

Answer 29

CH3

Question 30

Macrolide structure contains......suger,that is attached by .....

Answer 30

1-3 deoxy suger

Question 31

Erythromycin A,B are.......,while azithromycin and clarithromycin are...... macrolides

Answer 31

Matural,semi synthetic

Question 32

Macrolides moa.......,and targets......and.....bacteria

Answer 32

Protein synthesis inhibiting Gram + and mycoplasma

Question 33

Patients with penicillin allergy can use ...... antibiotics instead

Answer 33

Macrolide

Question 34

Macrolide se is mainly

Answer 34

GI symptoms

Question 35

Erythromycin a building blocks: ... propionyl coa, ...methylmalonyl coa

Answer 35

1.6

Question 36

Arythromycins are film coated bec they get....

Answer 36

Inactivated in stomach acidic media

Question 37

Macrolide may cause .....if it was used in high doses

Answer 37

Temporary loss of hearing

Question 38

Fir respiratory infections...can be used ..by both...and....

Answer 38

Azithromycin Adults and children

Question 39

Polyenes consist of large....that contain series of....

Answer 39

Lactone ring Conjugated double bonds

Question 40

Most medically important polyenes are heptaene ... and tetraene ...

Answer 40

amphotericin B Nystatin

Question 41

Polyenes are linkedvia a ......group to an .... unit

Answer 41

Hydroxyl amino suger

Question 42

..,...preduces polyene

Answer 42

Streptomyces

Question 43

... infections are treated by polyenes...

Answer 43

Candida albicans ..cutaneous.intestinal and vginal

Question 44

Amphitericin b (polyene) synthesis by..

Answer 44

One acytel coa 15 malonyl coa Three methyl malonyl

Question 45

Amphitericin b and nystatin contains ....suger

Answer 45

D-mycosamine

Question 46

Amphitericin b acts againts most fungus and yeast trie or false

Answer 46

True

Question 47

Amphitericin b is well absorbed from the gut true or false

Answer 47

False

Question 48

Oral administration of amphitericin is restricted for.....treatment

Answer 48

Intestinal candidiasis

Question 49

Amphitericin is administered iv for.....

Answer 49

Life threatening systematic fungul infections

Question 50

Nystatin is too toxic for iv injection but is used for intestinal candidiasis orally..true or false

Answer 50

True

Question 51

O

Question 52

O

Question 53

Antineoplastic anthracyclines produced by ...spp Their moa...

Answer 53

Streptomyces Inhibit DNA dependent RNA synthesis

Question 54

Antineoplastic anthracyclines synthesised from....and.....

Answer 54

One propionyl co a Nine malonyl coa

Question 55

... most successful antitumor,with the largest spectrum of tumers

Answer 55

Doxorubicin

Question 56

... is potent in treating breast cancer and has less side effect than ...

Answer 56

Epirubicin Doxorubicin

Question 57

... is a synthetic analogue of the anthracyclinones.

Answer 57

Mitoxantrone

Question 58

Mitoxantrone has ... toxicity than Doxorubicin and is effective for ... treatment

Answer 58

less leukemia and solid tumor