CH3- brain anatomy Flashcards

1
Q

neuroplasticity

A

NS can grow new branches on dendrites and change # of receptors and NT (changing neuron activity if neuros are damaged or as we grow) we lose neuros as we get older (the ones we dont need)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

neocortex (new brain)

A
  • the new brain (neo = new)
    Most of your cerebral cortex is considered to be the neocortex.
  • In humans, 90% of the cerebral cortex is the neocortex.
  • association cortex: adjacent to lobes, further processes info and inetgrate with other sensory info
  • share characteristics with primates (new brain)
  • wrinkly appearence due to gyri (ridges) sulci (valleys) and fissures(spaces)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

map of nervous system

A

peripheral + central
-peripheral: autonomic + somatic
- autonomic: sympathetic + parasympathetic
- somatic: sesnory input + motor output controls

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

PNS: SOmatic NS

A
  • neurons for voluntary motion
  • sensory infro from body to brain
  • if spinal cord injured, segment below, can no longer be controlled volunatririly

-

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

PNS: Autonomic NS

A
  • automatic functions (involuntaty movemnt)
  • sympathetic and parasympathetic NS
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

parasympathetic and sympathetic system

A

parasympathetic:
- rest and digest/ sexually arousal
- nerves originate in lower brains and bottom of spinal cord

sympathetic
- fight or flight
- nerves in length of spinal cord (main)
- sex stimulates this as well

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Pons + Medulla

A
  • connect teh PNS to teh CNS
  • pons above medulla, make up brainstem

Medulla
- lowest part of brainstem
- controls involuntary movements (heart rate, breathing, digestion, swallowing)

pons
- above medulla
- bridge
- regulate arousla
- COORDINATE Snsory info with info from cerebellum
- controls facial expressions, movement of the eye

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Reticular Activating System (RAS)

A
  • network spamming center of medulla and pons
  • bridges functions of body + brain via connections to spinal cord and thalamus
  • regulates elvels of excietment and energy
  • regulates focus of our attention on tasks, peopel or objects
  • filters irrelevant stimuli
  • dysfunctional: posible ADHD contributor
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

the limbic system

A
  • system that cooridinates movemnet

amygdala (emotion) :
- increases electricl activity in neurosn when under threat.
- forms memoires associated with strong emotions.
- recieves sensory input from all senses.
- connects with hippothalaums with thalamus
- damage here: causes loss of awareness of emotion and inapproprate responses in situations that normally trigger emotional responses.

hippocampus (memory):
- neurons activated when forming memories
- new memories and imigation
- connected to amygalda for memory of emotionally important events (for survival)
- important for spacial navigation

cingulate gyrus (pain-social exclusion):
- ventral to neocortex
- increase activity in this area in response to apin and social exclusion
- focuses attention on unpleasent experiences

hypothalamus (mainteneance of internal systems + endocrine system):
- directs several maitenance activities (body temp, sex, hunger) homeostaiss
- helps govern endocrine system via pituitary gland

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Basal Ganglia

A
  • consists of dorsal stritum (caudet nucleus and putamen) , ventral striatum, substantia nigra, subthalamic nucleus globus pallidus,
  • recieve info from midbrain (above pons)
  • responsibile for volunatry moovemnt (starting and stopping abrupt movemnts)
  • helps make complex movements automatic

striatum (learning to make movments more automatic):
- where inputs to basal ganglia come in (from ALL OVER CORTEX)
- how nuclei work togetehr to help us learn movemts from practice (make complex movemnt easier for us)
- dorsal stiatum (caudet nucleus and putamen):
- ventral stiatum neurons connect to limbic system (emotion = motivation to learn)

Globus Pallidus + subsantia nigra
- send inhibitory outputs to thalamus (integrate sensory and motor info with motor planning)
- helps with starting and stopping motion
- substantia nigra: neurons secrete dopamine . in parkinsosn disease, tehse cells die off, lose part ability to stop and start motion.

Pathways in Basal ganglia:
- direct pathway: excitatory effect on thalamus that drives motor behaviours. increase motor plans that are appropriate for present situation
- indirect pathway: inhibitory effect. helps basal ganglia shut down motor pathways taht are not right for task at hand
- if dmaaged: parkinsosn disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

parkinsons disease

A
  • progressive disease resulting in imparied movement
  • cogwheeel rigidty: touble initialiting and terminating movemnts
  • substantia nigra: neurons secrete dopamine . in parkinsosn disease, tehse cells die off, lose part ability to stop and start motion.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Cerebellum

A
  • rhythm and timing machine
  • looks like little brain
    -neuronal circuits connected to rest of brain to modify what thet do (movement and cognition)
  • recieves input from periphery, spinal cord and brain regions and partienal cortex.

spinocerebellar divison:
- match sensory input with motor plans in order to fine tune movemnt patterns

Vestibulocerebellar division:
- process information from inner ear to help adjust posture and balance

cerebrocerebellar division:
- manaes connectiosn with pons + thalamus to adjust timing and planning of movements

damage to cerebellaum:
- loss of balance uncoordination
- no paralysis tho
- planning timing is affected
- maybe problem solving is affected and emotional repsonse (neocortex and hypothalamus)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Thalamus

A
  • relay station
  • cortex uses to choose which thing we pay attention to
  • all senses (except smell) must pass through thalamas beofre going to respective areas of neocortex for interpretation
  • right and left lobes of thalamus sit above cerebellum
  • contain bands of myelinated axons.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Frontal lobes

A

-output tends to be inhibitory
- decsion making and movemnt
- phineas gage - his frontal lobe destroyed (became irritable and vulgar)

motor cortex:
- two major pathways: corticospinal and corticobular tracts. contorl movment in spinal and head respectively

prefrontal cortex (PCP):
- advanced decsion making. if….then
- recieves input from all cerebreal cortex
- inhibitaory and excitatory
- dysfunction here: presence of negative symptoms of schytophrenic patients
- mylenation occurs here (oligodendrocytes do it)
- ventromedial prefrontal cortex (vmPFc): modulate behavior based on fear (bottom inside part)
- dorsolateral prefrontal cortex (DLPFC): maintain info in working memory and change how we do things depending on task

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

pariental lobes

A
  • sensation navigation, motor action, numbers
  • lobe at back of head
  • procesing numbers and calculations
  • sensory cortez: recives input from contralater part of body (nerves cross at brainstem so youc an do crosslateral movemnt)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

temporal lobes

A
  • above ear
  • memories, sound processing, smell association
  • lesions: focues areas where cells have died. memory loss and loss to form new memories (antegrade amnesia)
  • connect to hippocampus (smell and memory)

auditory cortex:
- caudaul part of lobe
- if damaged: lose all ability to percieve sound wtho damage to ear

Wernicke’s area
- in left temporal lobe
- processing language
- if stroke: unable to comprehend speech

olfactory cortex
- smell is processed and percieved
- smell (olfactory) only sense that doesnt go to thalamus
- memory + olfactory = nostalgic smells

17
Q

Occiptial lobes

A
  • light stimuli processing
  • optic nerves end here
  • visual info from right visual field processed in left occipital lobe and left thalamus
    sensory info for eyes crosses at optical chiasma
  • damage: loss of sight, or ability to see specfic things liek faces
18
Q

Brain laterality

A
  • idea that one hemishphere of the brain preforms different functions than other
  • half true half not
  • we use both sides regularly (no one is completley laterialized)c
19
Q

corpus callosum

A
  • helps cross infro from one side of brain to other
  • thick bundle of fibers inside of brain
  • all sensory info excpet smell croses from one side to another
  • epilepsy: cut corpus which helps calm seizures. “split brain” pateints have trouble seeing stuff in left visual field and naming it
20
Q

Endocrine system

A
  • glands that secrete hormones
  • hormones can act as NT

hypothalamus
- secretes hormones and control pituitary glands. secrete oxytocin hormone (love hormone)

pineal gland
- secretes melatonin hormone that helps regulate sleep

pituitary gland
- secretes hormones that affect sexual behaviours, reproduction, circulatory function, hunger, repsosnes to agression

21
Q

HPA axis and Stress

A
  • stress, chornic stress, endocrine + brain connection
  • Hypothalaums-pituitary-adrenal axis
  • hypothalamus –> pituitary gland –> adrenal gland
  • chronic stress = increase hypothalmus neurons activated = pituitary gland to tell adrenal gland up increase cortisol production (stress hormone)
  • chornic stress = to much cortisol, deeling tired, alterness drecreases over time (affecting RAS)
  • increase cortisol = decrease immune system function
22
Q

Ct scans

A
  • x rays that pass through body to generate body image slices
  • fast cheap non invasive
  • harm: radiation exposure
  • detect change in structure from disease
23
Q

MRI and fMRI

A

-magnetic fields image alighnemts of H+ ions

MRI
- noninvaseive, no radiation, great precissonn
-con: expensive, no biomedical devices or metal in pateint
- can detetc change in structure from a disease

fMRI
- noninvaseive, no radiation, no ingestions/injections
- Cardiovascular diseases or compromised functions can make meausrements unreliable dely between stimulus and output
- can meausre activation of neuron during a task or follow stimulation

24
Q

PET scan

A
  • photon emmisoion tomography
  • ingest radioactive compound to tracj molecural change
  • see molecular change in real time
  • con: radioactive exposures
  • can visualize activity of NT or measure binding
24
Q

DTI

A
  • diffusion tensor image
  • images water movemnt along neural pthways and meausres density of neural tracts
  • non invasive, no ingestions/ injections
  • con: interpreation can be difficult in tracts with different fibers
  • can study white matter degeneration in a disease
25
Q

how did we develop current research methods in brain imaging

A
  • ancent egyptian scrolls about brain (1600 bce)
  • experiemental studies on brain (1700)
  • otto friedrich and karl ditrs (seperate neurons in late 1800s)
  • staining method: dye to viszualzi neurons in dead tissue - camillo golgi
  • 1990’s stained neurons in living tissue
  • 1700, frog leg dippied in electrical stimulation, energy make muslces move (luigi galvani)
26
Q

Patch clamp technique

A
  • ervin neher and bert sakmann
  • patch clamp to record electrical activity from individual neurons
  • glass lctrode is placed on membrane of enuron using suction
    -membrane oulled into electrode
  • stimulate and record patch of membrane see how recpetors and channleles influence electrical activity