ch21 cholinergic antagonist

Question 1

atropine Usual Adult Dosage Range

Answer 1

IV: 0.5-1 mg given every 3-5 min (max 3 mg)

Question 2

atropine Indications

Answer 2

Treatment of bradycardia, cardiopulmonary resuscitation

Question 3

dicyclomine (Bentyl) Usual Adult Dosage Range

Answer 3

PO: 80-160 mg/day divided qid

Question 4

dicyclomine (Bentyl) Indications

Answer 4

Treatment of irritable bowel syndrome

Question 5

oxybutynin (Ditropan, Ditropan XL, Oxytrol [transdermal patch]) Usual Adult Dosage Range

Answer 5

PO: 5 mg bid-qid;
ER tab: 5-30 mg/day in a single or divided doses

Transdermal patch: 1 patch (3.9 mg/day) applied twice weekly (every 3-4 days) (for overactive bladder)

Question 6

oxybutynin (Ditropan, Ditropan XL, Oxytrol [transdermal patch]) Indications

Answer 6

PO: Antispasmodic for neurogenic bladder (e.g., following spinal cord injury)

Transdermal Patch: Overactive Bladder

Question 7

scopolamine Usual Adult Dosage Range

Answer 7

IM/IV/subcut: 0.3-0.65 mg

Transdermal patch: 1.5 mg patch behind ear every 3 days; apply at least 4 hr before transportation

Question 8

scopolamine Indications

Answer 8

IM/IV/subcut: Preoperative control of secretions

Transdermal patch: Motion Sickness prevention

Question 9

tolterodine (Detrol, Detrol XL) Usual Adult Dosage Range

Answer 9

PO: 1-2 mg bid;

ER cap: 2-4 mg daily

Question 10

tolterodine (Detrol, Detrol XL) Indications

Answer 10

Treatment of overactive bladder