Ch1 AFFINITY

Question 1

receptor

Answer 1

protein or glycoprotein that sits on the cell surface, where it is bound to the membrane

Question 2

drug-receptor complex

Answer 2

If a drug binds to its receptor, it forms a drug-receptor complex (Figure 1-2). The outside of the cell is covered with a number of different receptors that can interact
with the drug. In other words, there are many sites to which drug molecules can bind.

Question 3

high K1

Answer 3

if a drug has a high affinity for its receptor it is “fast to make” there is a high rate oh drug-receptor binding

Question 4

high K-1

Answer 4

a high rate of breaking the drug-receptor complex

Question 5

low K1

Answer 5

the rate of making the drug-receptor complex is slow

Question 6

low K-1

Answer 6

when a drug-receptor complex is hard to break

Question 7

association rate (K1)

Answer 7

The binding of drugs and receptors occurs at a certain rate
[D] + [R] —-k1—> [DR]

Question 8

dissociation rate (K-1)

Answer 8

How quickly the drug dissociates
[DR] —–k-1—-> [D] + [R]

Question 9

dissociation constant (Kd)

Answer 9

The ratio of the rate of breakdown (k-1) to the rate of formation (k1) is called the dissociation constant (Kd)

Question 10

affinity

Answer 10

how attracted the drug is to the receptor