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Molec 1 > Ch 9 Repair Enzymes > Flashcards

Ch 9 Repair Enzymes Flashcards

0
Q

MutL

A

Activates MutH in E Coli

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1
Q

MutS

A

E Coli-scans DNA

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2
Q

MutH

A

Cleaves DNA in E Coli

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3
Q

MSH

A

Human-MutS

Interacts - sliding clamp

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4
Q

MLH/PMS

A

Homologue of MutL

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5
Q

Photolyase

A

Photoreactivation for Direct Reversal

E Coli

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6
Q

Methyltransferase

A

Group removal in Direct Reversal

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7
Q

Glycolase

A

MutM in E Coli
Removes G in oxoG:A
Base Excision Repair

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8
Q

MutT

A

Error Avoidance-E Coli

Remove G in oxoG b4 incorporation

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9
Q

MutY

A

E. Coli- Failsafe in Base Excision

Remove A in oxoG:A

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10
Q

MTH1

A

=MutT

In human Chr7p22

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11
Q

UvrA

A

Complex + Uvrb

Scan DNA in E. Coli Nucleotide Excision Repair

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12
Q

Uvrb

A

Recruits Uvrc

NER E.Coli

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13
Q

UvrC

A

Cut 8nt on 5’
4-5 on 3’
NER E.Coli

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14
Q

UvrD

A

Helicase

NER and Mismatch Repair in E. Coli

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15
Q

XPC

A

Human NER

homo 4 UvrA

16
Q

XPA-XPD

A

Human NER

homo 4 UvrB

17
Q

ERCC1-XPF

A

Cut 5’ end in human NER

homo 4 UvrC

18
Q

XPG

A

Cut 3’ end in human NER

Homo 4 UvrC

19
Q

TFIIH

A

Transcription Coupled Repair

NER

20
Q

LexA

A

Transcriptional Repressor

E. Coli Translesion Synthesis

21
Q

UmuC/UmuD

A

DNA Poly V

E. Coli Translesion Syn

22
Q

DinB

A

DNA Poly IV

E. Coli Translesion Syn

23
Q

Ku 70/Ku 80

A

NHEJ

VDJ Recombination

24
Q

DNA-PKcs

A

Eu- NHEJ & VDJ Recomb

25
Q

Artemis

A

Eu- NHEJ & VDJ Recomb

26
Q

BRCA1

A

Tumor Suppress Gene
Eu- Homo Recombination
Breast Cancer 1

27
Q

BRAC2

A

Tumor Suppressor
Bind & regulate proteins made by Rad51
Eu- HRR

28
Q

Rad51

A

Homo 4 Pro RecA & yeast Rad51

Eu-HRR

29
Q

Chk1

A

Prevent entry to mitosis

UV damage, replication error, p53 activation

30
Q

Chk2

A

Prevent Mitosis Entry
Interact BRCA1 = BRCA1 restore survival after damage
Repair of ionizing radiation

31
Q

RAG1 & RAG2

A

Eu- VDJ recomb

32
Q

p53

A 
47 kDa
Transcription Factor-recognize DNA erro
-DNA Damage, osmotic shock, nucleotide depletion, oncogene start
Hold cell G1 or S, or apoptosis
50% cancer has mutated p53
33
Q

Cdk2

A

Cell cycle regulator

34
Q

ATM

A

Target- p53, BRCA2, chk2, H2AX, RAD,
Activates- NHEJ, HRR, p53/chk2
Ds DNA Breaks

Molec 1 (2 decks)

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