Ch. 9 P53 Flashcards
1
Q
Mdm2
A
binds to p53 and triggers its ubiquitination
2
Q
ATM and ATR phosphorylate p53
A
prevents binding of Mdm2
3
Q
Binding of p53 and AP-1 and Ets
A
stimulate the transcription of mdm2
4
Q
ARF
A
binds to Mdm2 and inhibits it
5
Q
Inactivation of ARF by mutation or methylation of its promoter
A
can be demonstrated in many tumors
6
Q
blebs
A
patches of plasma membrane bubbles
7
Q
pyknosis
A
The nucleus collapses into a dense structure
8
Q
Bcl-2
A
acts as an anti-apoptotic agent; opposite of p53
9
Q
Cytochrome c molecules bind aggregate with Apaf-1 to form
A
the apoptosome
10
Q
Executioner caspases cleave
A
”death substrates”- products create the apoptotic cell phenotype
11
Q
P53 induces expression of the FAS death receptor, Induces expression of IGF
A
and inactivates IGFs to activate apoptotic pathway
