Ch 5 -- Substance use and addictive disorders Flashcards

1
Q

Defining addition (four DSM-V substance use disorder criteria)

A

1) Impaired control over use criteria
2) Social impairment criteria
3) Risky use criteria
4) Pharmacological criteria

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2
Q

Impaired control over use criteria (4 points)

A
  • Substance use of greater amounts/longer period than intended.
  • Persistent desire or unsuccessful attempts to control/cut down use
  • considerable time spent in activities to obtain substance, use of substance, or recovering from effects
  • craving or strong desire/urge to use substance
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3
Q

Social impairment criteria (3 points)

A
  • recurrent use results in failure to fulfill obligations at work, home, or school
  • persistent use despite social/personal problems caused/ exacerbated by substance use
  • progressive neglect of alternative social, occupational, or recreational activities
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4
Q

Risky use criteria (2 points)

A
  • recurrent use in circumstances where use is physically hazardous (e.g. while driving)
  • persist with substance use despite knowledge of physical/psychological problems caused or exacerbated by substance
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5
Q

Pharmacological criteria (2 points)

A
  • tolerance (increased dose or decreased effect)
  • withdrawal syndrome or use of drug to alleviate/avoid withdrawal symptoms (ex: keeps alcohol in the house to consume when in withdrawal to avoid those effects)
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6
Q

How many of the points/effects in the DSM-V substance use disorder criteria are considered moderate? How many are considered a severe substance use disorder?

A

4-5 = moderate
>6 = severe substance use disorder

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7
Q

Key concepts/changes of substance use disorders (2)

A

1) Loss or impairment of control
2) Addiction is a chronic relapsing disorder

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8
Q

Loss or impairment of control

A
  • difficult to discern when use is controlled versus not controlled
  • “harm” as index of loss of control
  • craving:
    - intense preoccupation, strong desire to use drug
    - subjective state, requires self-report
    - correlation between craving and drug use is poor; used as “after the fact” explanation of relapse
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9
Q

Addiction is a chronic relapsing disorder

A

Fundamentally altered nervous system. No cure, only remission of symptoms

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10
Q

The first non-substance related disorder?

A

Gambling

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11
Q

What criteria does gambling show?

A

loss of control, compulsive drive for reward, tolerance, withdrawal, preoccupied with thoughts of past gambling, planning for future gambling, sacrifice relationships, employment, education, finances to gamble

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12
Q

Models of addiction (4)

A

1) Disease Model (susceptibility and exposure)
2) Physical Dependence Model
3) Psychological Dependence Model
4) Reinforcement Model

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13
Q

Disease Model of Addiction history (3 points)

A

Addiction is a disease. American Association for the cure of Inebriates (1870) declares inebriety is a disease; objective-define as a disease, not sin; treatment rather than punishment

“Addiction” = term for excessive drug use by medical profession

1960 - Jellinek authored “The Disease Concept of Alcoholism”

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14
Q

Assumptions of the disease model of addiction

A

Addiction is a disease (predisposition version) - the approach is rehab/treatment:
- predisposition (genetic, biological); considered a permanent condition; not caused by drug
- loss of control over use; drugs produce uncontrollable cravings (one drink = one drunk)
- progression through stages

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15
Q

The Disease Model of Addition (susceptibility) summary

A

Both initial drug use and inherited susceptibility to uncontrolled drug use lead to repeated drug use. Repeated drug use leads to a loss of control.

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16
Q

Strengths of the Disease Model (susceptibility) (2)

A

1) Drug abuse is not “normal”; product of a disease process
2) predisposition explains why some people become addicted when exposed to drugs, but others do not

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17
Q

Weaknesses of the Disease Model susceptibility model

A

1) Predisposition yet to be isolated; metabolic/neuro factors influence a person’s response to drug.

Evidence for this: addicts have some control over consumption. Recovered alcoholics have been able to control consumption (e.g., in social situations, can drink a controlled amount) - This doesn’t fit with the “loss of control” part of the model”

2) no progression through stages

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18
Q

Assumptions of the addiction is a disease (drug exposure version)

A
  • no predisposition
  • brain changes with repeat exposure
  • altered brain leads to los of control over us
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19
Q

Disease model - exposure summary

A

initial drug use leads to repeated drug use which leads to altered brain function and then loss of control

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20
Q

Summation of Disease model (why it’s not helpful - 3)

A
  • whether addiction is or isn’t a disease depends on how disease is defied
  • there is little to be gained scientifically by claiming addiction is a disease (social/political value - treat not stigmatize addict)
  • high cost to society (War on Drugs - the price increase was not successful, people still paid)
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21
Q

Physical dependence model

A

Compulsive use of drugs is based on avoidance of withdrawal

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22
Q

Physical dependence model summary

A

initial drug use leads to repeated drug use, then physical dependence, then attempts at abstinence, then withdrawal symptoms, then relapse. Relapse then leads to attempts at abstinence again.

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23
Q

Autotoxin

A

substance left in the body following use of opium that produces opposite effects (early 20th century). Part of the physical dependence model of addiction

24
Q

Rationalities used for autotoxin

A
  • continued use to avoid effects of autotoxin (negative reinforcement)
  • withdrawal/abstinence syndrome
  • also occurs with alcohol (depressant)
  • generalized as explanation for all drug use – defining feature of addiction
25
Q

Assumptions of the physical dependence model of addiction (4)

A
  • addiction involves physiological dependence (withdrawal if drug stopped)
  • addictive drugs universally produce physiological dependence
  • compulsive use based on avoidance of withdrawal
  • dependence: compulsive drug use and physiological withdrawal
26
Q

Problems with the Physical dependence model of addiction (5)

A
  • not all addictive drugs produce substantive withdrawal syndromes (CNS depressants do; CNS stimulants do not)
  • compulsive drug use can occur without physical dependence
  • humans and animals voluntarily stop drug administration even though they experience withdrawal
    -cannot explain relapse long after physical dependence has disappeared
    -Fear of development of dependence led physicians to deny or reduce pain medications to patients
27
Q

Psychological dependence Mode

A

Alternative to the physical dependences model: addictive drugs produce unobservable psychological withdrawal syndrome and psychological withdrawal symptoms are so distressing that people are motivated to avoid them.

28
Q

Problems with the psychological dependence model (2)

A
  • circularity (excessive drug use is index of psychological dependence and psychological dependence causes excessive drug use)
    -resolution (evidence arising for physiological basis for psychological dependence)
29
Q

The current approach/addiction model is based on…

A

Self-administration (positive reinforcement model)

30
Q

Positive reinforcement model

A

Drugs are positive reinforcers. Reinforcement does not equal reward/pleasure. Animals self-administer drugs because they function as the reinforcers)

31
Q

To demonstrate that a drug is a reinforcer

A
  • increase in behaviour that produces drug when delivery of drug is contingent upon behaviour.
  • behaviour decreases when the delivery of the drug no longer occurs following behaviour (extinction)
32
Q

Strengths of the reinforcement model of addiction (evidence against two other models)

A

Evidence against dependence model:
- animals self-administer doses of morphine too low for physical dependence to develop
- animals self-administer cocaine/stimulants that do not produce a substantive withdrawal syndrome

Evidence against disease model:
- drug self-administration obeys the same principles as “normal” behaviour, not a product of a disease process

33
Q

Positive reinforcement model summary:

A

initial drug use leads to positive reinforcement (euphoria), which leads to repeated drug use, leads to attempts at abstinence, leads to compulsive desire to re-experience drug-induced euphoria, leads to relapse. Relapse leads pack to attempts at abstinence

34
Q

Animal Models (Rats). What are they fond of, what will they press for, what do they not like?

A
  • fond of: cocaine, valium, amphetamine
    -will press for alcohol
  • don’t like (will not press for): LSD, antidepressants, antipsychotic (all things humans don’t become addicted to)
35
Q

Problems for a positive reinforcement model (2)

A

1) paradox
2) circularity

36
Q

Resolution for paradox issue in the positive reinforcement model (+ what is the paradox?)

A

Paradox: people/animals continue to use drugs despite aversive consequences.
- Monkeys with free access to cocaine refuse to eat and sleep, self-inflict wounds, or die from overdose or from sustained injury, all the while continuing to use the drug.

Resolution:
- positive effects: immediate and more consistent
- averse effects: delayed and less frequent
- later aversive effects exert less control over behaviour than immediate positive effects

37
Q

Resolution for circularity issue in the positive reinforcement model (+ what is the circularity issue?)

A

Circularity: using drug because it is a reinforcer, but the drug use (self-administration) defines drug as reinforcer.

Resolution:
- use principles of reinforcement to make predictions about how drugs will affect behaviour; if predictions are confirmed, this illustrates utility of this approach.
- Define and study neural mechanisms underlying reinforcement

38
Q

Drugs differ in capacity to function as positive reinforcers. _______ is the most robust reinforcer and is used as a _______

A

Cocaine is the most robust reinforcer and is used as a standard against which we compare the reinforcing value of other drugs

39
Q

Factors that affect the incentive value of drugs (12)

A

1) Dose of drug
2) Genetic differences
3) Relief of unpleasant symptoms
4) Task demands
5) Stress
6) Deprivation
7) Prior experience with other drugs
8) Prior experience with same drugs
9) Withdrawal
10) Extended access (duration of access)
11) Priming
12) Conditioned reinforcement

40
Q

Dose of drug

A

Graph (upside down U)
- typical finding: are doses are generally more reinforcing than small doses. BUT, very high doses may show a decline in reinforcement value

41
Q

Genetic differences

A
  • genetic predispositions to prefer certain drugs
  • Evidence: alcohol-preferring and alcohol-avoiding strains of rates bred for use in studies of alcohol. Strain differences also developed for cocaine/opiates.
42
Q

Relief of unpleasant symptoms (4 points)

A
  • incentives are for self-administration based on relief of unpleasant symptoms (therapeutic effect)
  • drug use: self-medication (alcohol alleviates stress or depression and benzodiazepines alleviate anxiety, nicotine improves attention)
  • Predict: individuals susceptible to stress/anxiety are more likely to abuse alcohol/diazepam, but no substantive support
  • opiates are self-administered to alleviate pain
43
Q

Task demands (4 points)

A
  • decision to use or not to use a drug can depend on expected demands of a task
  • if participants had to do a vigilance task, 7/8 choose amphetamine capsules over placebo/BZ
  • if they had to do a relaxation task (lie in bed for 50 min without moving), 8/8 chose triazolam (BZ)
  • if they had to do a painful task, participants reliably chose nitrous oxide or fentanyl (had an analgesic effect)
44
Q

Stress (4)

A
  • stress leads to drug use
  • experimental evidence: stress enhances acquisition of drug self-administration, increasing reinforcing value of drugs
  • stress hormones stimulate mesolimbic dopamine (MLDA) system - enhances reinforcing value of drugs and drug-related stimuli
  • rates will self-administer stress hormone (corticosterone)
45
Q

Deprivation (4)

A

food deprivation enhances drug self-administration
- occurs with alcohol; however alcohol is a source of calories (food)
- occurs with drugs that provide no calories (cocaine)
- deprivation is a stressor; may just be another example of a stress effect

46
Q

Prior experience with other drugs (3)

A
  • if drugs share mechanism of action, experience with one produces preference for another
  • alcohol users show a preference for diazepam (both enhance ability of Gabba neurons (are Gabba antagonists). This is why benzodiazepines are used as a therapy for alcoholics
  • baboons self-administer diazepam when switched from bento barbital, but not when switched from cocaine (cocaine is a dopamine agonist, no effect on Gabba)
47
Q

Prior experience with the same drug (1)

A

history of self administration or passive exposure to a drug enhances its reinforcing ability

48
Q

Withdrawal (3)

A
  • withdrawal/dependence affects reinforcing value of drugs
  • physically dependent animals that experience abstinence for a period of time show an increased rate of self-administration
  • breakpoints (BP) on progressive ratio schedules are higher in animals that are physically dependent on morphine/codeine than drug naive animals
49
Q

Extended access (duration of access) (2)

A
  • short daily sessions lead to stable levels of consumption; continuous access leads to escalating consumption, death from overdose/side effects
  • cocaine (stable consumption with one hour access, consumption escalates over 12 days with 6 hours access)
50
Q

Priming (5)

A
  • stimulation of responding for a reinforcer by a non-contingent presentation of that reinforcer
  • AKA, reinstatement
  • occurs with presentation of same drug, different drug, or infusion into ventral tegmental area (VTA)
  • used to explain relapse following long periods of abstinence
    -Triggers: exposure to the drug, stress, cues associated with prior drug administration
51
Q

Conditioned reinforcement (3)

A
  • Neutral stimuli paired with or predictive of a reinforcing stimulus acquire value as conditioned reinforcers through classical conditioning
  • demonstrated by pace conditioning (context associated with a drug effect is preferred or avoided) and second order schedules (animals lever press to produce a stimulus that is associated with the delivery of a drug)
52
Q

Chart of most dangerous drugs. Most overall, most harm to the user, largest mortality?

A
  • Alcohol is the most dangerous overall (highest in harm to others)
  • Cocaine is the most harmful to the user
  • Heroin has the largest mortality rate
53
Q

Most addictive drugs according to Nutt et al. (2007) (5)

A
  • heroin
  • cocaine
  • nicotine
  • barbiturates
  • alcohol
54
Q

Most addictive drugs according to NIDA (5)

A
  • heroin
  • cocaine
  • methamphetamine
  • alcohol
  • nicotine
55
Q

What drug is not on either the Nutt et al. list nor the NIDA list but has a high mortality?

A

Fentanyl