ch. 5 & 6 short answers Flashcards
explain the 5 step life cycle of animal viruses
absorption
penetration
synthesis
assembly
release
absorption
virus enters a susceptible host cell and absorbs to receptor sites on cell membrane
penetration/uncoating
the entire virus is engulfed by the cell and enclosed in a vacuole/ vesicle
synthesis
the viral nucleic acid begins to synthesize the building blocks for new viruses
assembly
mature virus particles are constructed from the growing pool of parts. the capsid is laid down as an empty shell that will be receptacle for the nucleic acid strand
release
assembled viruses leave their host. non-enveloped viruses that reach maturation in the cell nucleus are released when the cell lyses/ruptures. the nucleocapsid binds to the membrane
lytic bacteriophage infections
destroys the host cell
lysogenic conversion
when a bacterium acquires a new trait from its temperate phage
what are 3 ways in which viruses are cultivated
using live animal inoculation
using bird embryos
using cell (tissue) culture techniques
3 purposes of cultivating viruses
isolate and identify viruses in clinical specimens
prepare viruses for vaccines
do detail research on viral structure, multiplication cycles, genetics, and effects on host cells are cultivated
explain why antiviral drugs are difficult to develop and why its advantages to taken in the first 48 hrs of symptoms
viruses borrow host proteins and functions to propagate themselves, so it is difficult to find drugs that will help without damage caused to the cell
7 properties of viruses
- are obligate intracellular parasites of bacteria, protozoa, fungi, algae, plants and animals
- are ubiquitous in nature and have had major impact on development of biological life
- are NOT cells, structures are very compact and economical
- do not dependently fulfill the characteristics of life
- basic structure consists of protein shell surrounding nucleic acid core
- nucleic acid can be RNA or DNA but NOT both
- nucleic acid can be double stranded DNA/RNA or single stranded RNA/DNA
- molecules on virus surface give them high specificity for attachment to host cell
- multiple by taking control of host cell’s genetic material and regulating the synthesis and assembly of new viruses
10 . lack enzymes for most metabolic processes - lack machinery for synthesizing proteins
are viruses dead or alive? explain fully.
there are two viewpoints about this question: one says that since they can’t reproduce independently from the host cell, then they are not living and they should be call infectious molecules.
the other viewpoint is that even thought they don’t have most life processes the viruses can direct them and they are more inert and lifeless molecules
3 DNA viruses
2 stranded:
variola virus: small pox
herpes simplex 2: genital herpes
single stranded:
parvovirus: erythema infection
4 RNA viruses
single stranded
(+) poliovirus: poliomyelitis
(-) influenza virus: influenza
HIV: AIDS
double stranded:
rotavirus: gastroenteritis