Ch 4 - Pharmocokinetics Flashcards
Change in the drug structure…
Absorption
Distribution
Elimination
Excretion
Metabolism
Pharmacokinetics
Metabolism
Change in the drug structure and movement out of the body…
Absorption
Distribution
Elimination
Excretion
Metabolism
Pharmacokinetics
Elimination
Movement from blood into tissue cells…
Absorption
Distribution
Elimination
Excretion
Metabolism
Pharmacokinetics
Distribution
Movement into and out of the body…
Absorption
Distribution
Elimination
Excretion
Metabolism
Pharmacokinetics
Pharmacokinetics
Movement into the blood…
Absorption
Distribution
Elimination
Excretion
Metabolism
Pharmacokinetics
Absorption
Movement out of the body…
Absorption
Distribution
Elimination
Excretion
Metabolism
Pharmacokinetics
Excretion
My require expenditure of energy…
a. Passes through channels
b. Direct penetration of the membrane
c. Passage with the aid of a transport system
c. Passage with the aid of a transport system
Requires small size…
a. Passes through channels
b. Direct penetration of the membrane
c. Passage with the aid of a transport system
a. Passes through channels
Requires lipid solubility…
a. Passes through channels
b. Direct penetration of the membrane
c. Passage with the aid of a transport system
b. Direct penetration of the membrane
True or False:
Cell membranes are composed of fat with phosphate
true
True or False:
Most drugs enter cells through channels or pores
False
True or False:
P-glycoprotein transports many drugs out of the cells
True
True or False:
A transport mechanism is needed for a water-soluble drug to enter a cell
true
True or False:
Ionization is a process that allows a drug to enter a cell
False
ionization can occur when ionizing radiation passes through cells, removing electrons from atoms and molecules. This can alter the chemical composition of cells and damage DNA, which can lead to cell death or mutation (cancer)
True or False:
If a quaternary ammonium compound drug is injected into a vein, it will produce effects, but it will not if taken orally.
True
True or False:
Polar drugs can enter fetal circulation and breast milk
False
True or False:
Aspirin, like most drugs, is primarily absorbed in the small intestine
False
Stomach
True or False:
Enteric drugs should not be crushed because crushing these can cause stomach distress or cause the acid i the stomach to alter the drug
True
True or False:
IM injection of an antibiotic to treat syphilis will be completely effective within 24 hours after administration
False
True or False
The protein-bound portion of a drug in circulation is not able to exert its action
True
