Ch. 3: Neuroscience and Behaviour Flashcards
What are neurons?
Cells in the nervous system that communicate with each other to perform information-processing tasks
What are the 3 basic parts of a neuron?
- Cell body
- Dendrites
- Axon
What is the cell body also called?
The soma
What is the cell body, and what does it do?
- the largest component of the neuron, which contains the nucleus (DNA/chromosomes) and is enclosed by a porous cell membrane
- the part of the neuron that coordinates information-processing tasks and keeps the cell alive
- where functions such as protein synthesis, energy production, and metabolism take place
What do the dendrites do?
Receive information from other neurons and relay it to the cell body
What does the axon do?
Carries information to other neurons, muscles, or glands
What is the myelin sheath, and what is it made of?
- An insulating layer of fatty material that covers the axon in many neurons
- Insulates the axon and allows it to carry information more efficiently
- Composed of glial cells
What are glial cells, and what might they do?
- Support cells found in the nervous system
- Some digest parts of dead neurons, others provide physical/nutritional support for neurons, and other form myelin
What happens in demyelinating diseases, like MS?
The myelin sheath deteriorates, slowing down communication between neurons; leads to loss of feeling in limbs, partial blindness, difficulties with coordination/cognition, etc.
What is a synapse?
The region between the axon of one neuron and the dendrites or cell body of another
What are the 3 major types of neurons?
- Sensory neurons
- Motor neurons
- Interneurons
What do sensory neurons do?
Receive information from the external world and convey it to the brain via the spinal cord; have specialized endings on their dendrites that receive signals for light, sound, touch, taste, or smell
What do motor neurons do?
Carry signals from the spinal cord to the muscles to produce movement; often have very long axons to reach muscles at the extremities
What do interneurons do?
- Connect sensory neurons, motor neurons, and other interneurons
- Work together in small circuits to perform simple tasks (ex. identifying the location of a sensory signal)
- Work together in circuits to perform more complicated tasks (ex. recognizing a familiar face)
- Make up most of the nervous system
What were the 3 specialized neuron types we studied?
- Purkinjie cells
- Pyramidal cells
- Bipolar cells
What are purkinjie cells?
A type of specialized interneuron that carries information from the cerebellum to the rest of the brain and the spinal cord; have dense, elaborate dendrites that resemble bushes
What are pyramidal cells?
Specialized cells in the cerebral cortex; have a triangular cell body and a single, long dendrite among may smaller dendrites
What are bipolar cells?
A type of specialized sensory neuron found in the retinas of the eyes; have a single axon and a single dendrite
What are the 2 stages of communication between neurons?
- Conduction
2. Transmission
What is conduction when it comes to neurons?
The movement of an electric signal within neurons, from the dendrites to the cell body, then throughout the axon
What is transmission when it comes to neurons?
The movement of a signal from one neuron to another as a result of chemical signalling across the synapse
Together, what are conduction and transmission in a neuron called?
Electrochemical action of neurons
What is a resting potential? What is its charge?
- The difference in electric charge between the inside and outside of a neuron’s cell membrane; a natural electric charge
- about -70 millivolts
What causes the charge of a neuron’s resting potential?
- The difference in concentrations of ions inside and outside the neuron’s cell:
- In a resting state, there is a high concentration of K+ ions and protein (A-) ions inside the cell membrane and a high concentration of Na+ and Cl- ions outside; since A- ions are larger and carry a stronger charge, the inside of the cell is relatively negatively charged
What happens during a resting potential in a neuron that makes an action potential possible?
-An active channel “pump” maintains a high concentration of K+ ions inside the cell membrane and a high concentration of Na+ ions outside; the difference in concentration is what prompts ions to move across the membrane once their specific channel is open
What is an action potential, and when does it occur?
- An electric signal that is conducted along the length of a neuron’s axon to a synapse
- Occurs only when electric stimulation is at or above the threshold
When it comes to an action potential, what is meant by “all or none”?
- Electric stimulation below the threshold fails to produce any action potential
- There is no difference in the strength of the action potential based on the strength of the simulation; action potentials are always the same magnitude
What is the charge of an action potential?
+40 millivolts
What is the cause of positive surge in charge of an action potential?
Na+ channels in the cell membrane are opened, so the Na+ ions outside the cell rush into the cell since it is an area of low concentration
What 2 events restore the negative charge of the resting potential?
- Na+ channels inactivate themselves for several milliseconds, stopping the flow of Na+ ions into the cell
- K+ channels open, allowing excess K+ ions inside the cell to escape; the K+ channels close once the inside of the cell has a negative charge
The cycle then repeats, starting with the ion pumps pushing Na+ out and pulling K+ in and creating a resting potential
What is a refractory period, and what is its benifit?
- The time following an action potential during which a new action potential cannot be initiated
- Limits the number of times per second a neuron can fire and keeps the action potential from travelling back towards the cell body
How often can an action potential happen?
More than 100 times per second in some neurons
How does an action potential move along the length of the neuron?
- The Na+ ions being let into the neuron spread down the inside of it and increase the electrical charge as they go
- As the charge increases, it triggers subsequent voltage-gated channels to open and even more Na+ flows in until a charge of +40 millivolts is reached
- Ensures the action potential travels the full length of the neuron and that the intensity remains consistent
What is saltatory conduction and what is its benefit?
-Myelin prevents electric current from leaking out of the axon, so the current appears to
“jump” quickly from one node of Ranvier to the next
-Speeds up the flow of information down the axon
What are terminal buttons?
Knoblike structures at the end of an axon; each is filled with tiny vesicles (sacs) that contain neurotransmitters
What are neurotransmitters?
Chemicals that transmit information across the synapse to a receiving neuron’s dendrites
On a neuron, what are receptors?
Parts of the cell membrane that receive neurotransmitters and either initiate or prevent a new electric signal
What is a presynaptic neuron?
The neuron that sends the action potential
What is a postsynaptic neuron?
The neuron that receives that action potential
What is synaptic transmission, and what is its function?
- The sending and receiving of chemical neurotransmitters
- Underlies thoughts, emotions, and behaviour
Describe the process of an action potential
See written notes
Describe the process of synaptic transmission
See written notes
In what 3 ways can neurotransmitters leave the synapse?
- Reuptake
- Enzyme deactivation
- Diffusion
What is reuptake when it comes to neurotransmitters?
Neurotransmitters are absorbed by the terminal buttons of the presynaptic neuron’s axon or by neighbouring glial cells
What is enzyme deactivation when it comes to neurotransmitters?
Neurotransmitters are destroyed by enzymes in the synapse; specific enzymes break down specific neurotransmitters
What is diffusion when it comes to neurotransmitters?
Neurotransmitters drift out of the synapse and can no longer reach receptors
What is an autoreceptor?
Receptor sites on the presynaptic neuron that can detect how much of a neurotransmitter has been released into a synapse and may stop the release of more
What is Acetylcholine (ACh)?
- A neurotransmitter involved in a number of functions including voluntary motor control
- Activates muscle movements and contributes to:
- regulation of attention
- learning
- sleeping
- dreaming
- memory
- Found in neurons in the brain and synapses where axons connect to muscles/body organs
What condition is associated with Acetylcholine (ACh)?
Alzheimer’s disease: associated with the deterioration of ACh-producing neurons
What is dopamine?
- A neurotransmitter that regulates:
- motor behaviour
- motivation
- pleasure
- emotional arousal
- Plays a role in basic motivated behaviours such as seeking pleasure or associating actions with rewards (especially in drug addiction)
What conditions are associated with dopamine?
- High levels of dopamine in some brain pathways are linked to schizophrenia
- Low levels in other areas are linked to Parkinson’s disease
What is Glutamate?
The major EXCITATORY neurotransmitter in the brain; enhances transmission of information between neurons
What condition is linked to Glutamate?
Too much glutamate can cause neurons to become overactive and lead to seizures
What is GABA (gamma-amniobutyric acid)?
The primary INHIBITORY neurotransmitter in the brain; tends to prevent the firing of neurons
What condition is associated with GABA?
Too little GABA can cause neurons to become overactive and lead to seizures
What is an agonist?
A drug that increases the action of a neurotransmitter
What is an antagonist?
A drug that diminishes the function of a neurotransmitter
What is L-Dopa? Is it an agonist or an antagonist?
- A drug used to treat Parkinson’s disease (loss of neurons that make dopamine)
- Increases the concentration of L-dopa and spurs the surviving neurons to produce more dopamine
- Agonist for dopamine
What is amphetamine? Is it an agonist or an antagonist?
- Stimulates the release of norepinephrine and dopamine while also blocking their reuptake
- Excess of neurotransmitters results in euphoria, wakefulness, a burst of energy, and increased heart rate
- Agonist
What is cocaine? Is it an agonist or an antagonist?
- Prevents reuptake of neurotransmitters
- Acts on different areas of the brain than amphetamine
- Agonist
What are opioids? Are they agonists or an antagonists?
- Drugs, mostly used as pain killers or recreationally, that can be naturally (morphine, heroin) or synthetically (oxy, hydrocodone, fentanyl) derived
- Agonists for endorphins
- Antagonists for neurotransmitters involved in the perception of pain
- Diminishes brain stem’s sensitivity to CO2, resulting in depressed breathing or asphyxiation in an overdose
What is naloxone? Is it an agonist or an antagonist?
- Technically an opioid
- Binds to opioid receptors and blocks agonists like heroin
- Antagonist
What is Prozac? Is it an agonist or an antagonist?
- SSRI; blocks reuptake of serotonin
- Leads to serotonin remaining in the synapse longer, greater activation of serotonin receptors, and elevated mood
- Agonist
What is Propanalol? Is it an agonist or an antagonist?
- Beta blocker
- Obstructs receptor sites in the heart for norepinephrine and results in lower heart rate
- Antagonist
What are nerves?
Bundles of axons and the glial cells that support them; neurons are the building blocks of nerves